In:
International Journal of Cancer, Wiley, Vol. 137, No. 12 ( 2015-12-15), p. 2846-2857
Abstract:
What's new? Often, head and neck cancers are categorized by HPV16 status, because the presence of the virus tends to correlate with better survival. But the presence of HPV16 DNA in the tumor may not influence the disease characteristics if that DNA isn't expressed. These authors examined gene expression profiles and molecular characteristics of HNSCC cells, and found that those containing HPV16 DNA, but not RNA, shared characteristics with those containing no HPV16 DNA at all. Thus, to get meaningful predictive information about the cancer, it's important to verify that the HPV16 DNA is being expressed by testing for HPV16 RNA.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
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