In:
PLOS Pathogens, Public Library of Science (PLoS), Vol. 18, No. 6 ( 2022-6-3), p. e1010569-
Abstract:
We describe the longitudinal kinetics of the serological response in COVID-19 recovered patients over a period of 14 months. The antibody kinetics in a cohort of 192 recovered patients, including 66 patients for whom follow-up serum samples were obtained at two to four clinic visits, revealed that RBD-specific antibodies decayed over the 14 months following the onset of symptoms. The decay rate was associated with the robustness of the response in that antibody levels that were initially highly elevated after the onset of symptoms subsequently decayed more rapidly. An exploration of the differences in the longitudinal kinetics between recovered patients and naïve vaccinees who had received two doses of the BNT162b2 vaccine showed a significantly faster decay in the naïve vaccinees, indicating that serological memory following natural infection is more robust than that following to vaccination. Our data highlighting the differences between serological memory induced by natural infection vs. vaccination contributed to the decision-making process in Israel regarding the necessity for a third vaccination dose.
Type of Medium:
Online Resource
ISSN:
1553-7374
DOI:
10.1371/journal.ppat.1010569
DOI:
10.1371/journal.ppat.1010569.g001
DOI:
10.1371/journal.ppat.1010569.g002
DOI:
10.1371/journal.ppat.1010569.g003
DOI:
10.1371/journal.ppat.1010569.g004
DOI:
10.1371/journal.ppat.1010569.g005
DOI:
10.1371/journal.ppat.1010569.g006
DOI:
10.1371/journal.ppat.1010569.s001
DOI:
10.1371/journal.ppat.1010569.s002
DOI:
10.1371/journal.ppat.1010569.s003
DOI:
10.1371/journal.ppat.1010569.s004
DOI:
10.1371/journal.ppat.1010569.s005
DOI:
10.1371/journal.ppat.1010569.s006
DOI:
10.1371/journal.ppat.1010569.s007
DOI:
10.1371/journal.ppat.1010569.s008
DOI:
10.1371/journal.ppat.1010569.s009
DOI:
10.1371/journal.ppat.1010569.s010
DOI:
10.1371/journal.ppat.1010569.s011
DOI:
10.1371/journal.ppat.1010569.s012
DOI:
10.1371/journal.ppat.1010569.s013
DOI:
10.1371/journal.ppat.1010569.r001
DOI:
10.1371/journal.ppat.1010569.r002
DOI:
10.1371/journal.ppat.1010569.r003
DOI:
10.1371/journal.ppat.1010569.r004
DOI:
10.1371/journal.ppat.1010569.r005
DOI:
10.1371/journal.ppat.1010569.r006
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2205412-1
Permalink