In:
Cancer Research, American Association for Cancer Research (AACR), Vol. 77, No. 13_Supplement ( 2017-07-01), p. 5320-5320
Abstract:
Background: Nutrients involved in one-carbon metabolism - folate, vitamins B6 and B12, methionine, choline, and betaine - have been associated with multiple cancer sites. However, no study has assessed the association between these nutrients and risk of melanoma. Thus, the aim of this study was to evaluate the association between intake of these nutrients and melanoma risk within two prospective cohorts: the Nurses’ Health Study (NHS) and Health Professionals Follow-up Study (HPFS). Methods: The cohorts included a total of 81,685 women in the NHS (1984 to 2010) and 49,617 men in the HPFS (1986 to 2010). We assessed nutrient intakes using a semi-quantitative food frequency questionnaire every 2 to 4 years. Total nutrient intake included both dietary and supplemental intake. Dietary intake included intake from food only. Study physicians reviewed medical and pathological records to confirm self-reported cases of invasive melanoma. We used Cox proportional hazards regression to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) and then pooled the HRs for both cohorts using a random effects model. Results: Over 24 to 26 years of follow-up, we documented 1,321 cases (641 men and 680 women) of invasive melanoma. Higher intake of folate from food only, but not total folate, was associated with increased risk of melanoma. The pooled multivariable HRs for the top versus bottom quintiles were 1.17 (95 % CI: 0.98-1.41; P for trend = 0.17) for total folate and 1.37 (95 % CI: 1.13-1.65; P for trend = 0.001) for folate from food only. The association was statistically significant in men, but not in women. Higher intake of vitamins B6 and B12, choline, betaine, and methionine was not associated with risk of melanoma. Conclusion: We found some evidence that folate from food only, but not total folate, was associated with a modest increased risk of melanoma - a finding that warrants further investigation. Conversely, our findings suggest that other nutrients involved in one-carbon metabolism do not play an important role in the etiology of melanoma. Citation Format: Ashar Dhana, Hsi Yen, Tricia Li, Michelle Holmes, Abrar Qureshi, Eunyoung Cho. Folate and other nutrients related to one-carbon metabolism and risk of melanoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 5320. doi:10.1158/1538-7445.AM2017-5320
Type of Medium:
Online Resource
ISSN:
0008-5472
,
1538-7445
DOI:
10.1158/1538-7445.AM2017-5320
Language:
English
Publisher:
American Association for Cancer Research (AACR)
Publication Date:
2017
detail.hit.zdb_id:
2036785-5
detail.hit.zdb_id:
1432-1
detail.hit.zdb_id:
410466-3
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