In:
The EMBO Journal, EMBO, Vol. 35, No. 8 ( 2016-04-15), p. 831-844
Abstract:
image Mutations in the RN ase H2 enzyme complex are the most frequent cause of the autoinflammatory condition Aicardi–Goutières syndrome ( AGS ). It is thought that nucleic acid sensing is responsible for initiating inflammation; however, the nature of the nucleic acid‐sensing pathway has not been determined. Here, we establish that: Rnaseh2b A174T/A174T mice upregulate interferon‐stimulated genes ( ISG ) in tissues. ISG response is dependent on the nucleic acid sensor cyclic GMP ‐ AMP synthase ( cGAS ) and its adaptor STING . ISG induction is associated with reduced ribonucleotide excision repair ( RER ) activity and increased DNA damage.
Type of Medium:
Online Resource
ISSN:
0261-4189
,
1460-2075
DOI:
10.15252/embj.201593339
Language:
English
Publisher:
EMBO
Publication Date:
2016
detail.hit.zdb_id:
1467419-1
detail.hit.zdb_id:
586044-1
SSG:
12
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