In:
Microscopy and Microanalysis, Oxford University Press (OUP), Vol. 5, No. S2 ( 1999-08), p. 1178-1179
Abstract:
Whole body exposure to the chemical warfare agent, mustard gas, bis-(2-chloroethyl) sulfide, or its laboratory model compound, half mustard, 2-chloroethyl ethyl sulfide (CEES), induces cutaneous, respiratory and ocular impairments. Of these, ocular damage causes the most immediate incapacitation with initial symptoms evident within minutes. This incapacitation is a result of irritation and edema of eyelids, conjunctiva and especially cornea. Development of corneal epithelial lesions and edema leads to deterioration of corneal transmissive and refractive properties with untoward effects on visual acuity. Heretofore, there has been no specific pretreatment, or antidotal therapy for mustard gas-induced ocular impairment. In the present study, we describe morphological correlates of the apparent attenuation of such damage by a mixture compound developed by Varma et al. Varma mixture (VM) consists of compounds known to provide bio-energetic support, prevent oxidative stress, modulate membrane permeability and support tissue metabolism. The mustard agent used in this study was CEES.
Type of Medium:
Online Resource
ISSN:
1431-9276
,
1435-8115
DOI:
10.1017/S1431927600019218
Language:
English
Publisher:
Oxford University Press (OUP)
Publication Date:
1999
detail.hit.zdb_id:
1481716-0
SSG:
11
SSG:
12
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