In:
Arteriosclerosis, Thrombosis, and Vascular Biology, Ovid Technologies (Wolters Kluwer Health), Vol. 29, No. 11 ( 2009-11), p. 1871-1873
Abstract:
We show activation of platelet PPARβ/δ results in binding to and repression of PKCα, thus providing a signaling pathway for PPARβ/δ in platelets. Deletion of PPARβ/δ in murine platelets resulted in a loss of the inhibitory effects on adhesion and cAMP release, indicating PPARβ/δ is involved in platelet activation pathways.
Type of Medium:
Online Resource
ISSN:
1079-5642
,
1524-4636
DOI:
10.1161/ATVBAHA.109.193367
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2009
detail.hit.zdb_id:
1494427-3
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