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  • 1
    Online Resource
    Online Resource
    Cellular network of damage caused by exposure to high ambient temperature in Wistar rats: The role of Hsp70
    Elsevier BV ; 2023
    In:  Journal of King Saud University - Science Vol. 35, No. 5 ( 2023-07), p. 102654-
    Details
    In: Journal of King Saud University - Science, Elsevier BV, Vol. 35, No. 5 ( 2023-07), p. 102654-
    Type of Medium: Online Resource
    ISSN: 1018-3647
    URL: Article
    DOI: 10.1016/j.jksus.2023.102654
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2023
    detail.hit.zdb_id: 2514731-6
    SSG: 11
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  • 2
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    Online Resource
    Qualitative Histologic Assessment vs. Geomorphometric Analysis of Nerve Fiber Shape after the Intraneural Application of Liposomal Bupivacaine
    SciELO Agencia Nacional de Investigacion y Desarrollo (ANID) ; 2023
    In:  International Journal of Morphology Vol. 41, No. 3 ( 2023-06), p. 804-810
    Details
    In: International Journal of Morphology, SciELO Agencia Nacional de Investigacion y Desarrollo (ANID), Vol. 41, No. 3 ( 2023-06), p. 804-810
    Type of Medium: Online Resource
    ISSN: 0717-9502
    URL: Article
    DOI: 10.4067/S0717-95022023000300804
    Language: English
    Publisher: SciELO Agencia Nacional de Investigacion y Desarrollo (ANID)
    Publication Date: 2023
    detail.hit.zdb_id: 2570913-6
    SSG: 7,36
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  • 3
    Online Resource
    Online Resource
    Correlation of Long Bone Length and Number of Nutrient Foramina – Importance in Everyday Clinical Practice
    Sciencedomain International ; 2021
    In:  Journal of Pharmaceutical Research International ( 2021-12-28), p. 33-41
    Details
    In: Journal of Pharmaceutical Research International, Sciencedomain International, ( 2021-12-28), p. 33-41
    Abstract: Aims: Nutrient artery is the principal source of nutrition to the long bones. The topography of nutrient foramina on long bones is well known, but it has not yet been established whether the number of nutritive foramina (NF) is related to total bone length. The objective of the present study was to study the correlation of total number of nutrient foramina and long bone length of upper and lower limb to provide detailed data on such features. Study Design: A cross-sectional, descriptive study Place and Duration of Study: Department of anatomy, Medical Faculty University of Sarajevo. Study duration was 3 months. Methodology: In the present study, 300 adult human long bones of the upper (50 humeri, 50 radii, 50 ulnae) and lower (50 femora, 50 tibiae, 50 fibulae) limbs were investigated to determine the number of their nutrient foramina. The nutrient foramina were identified analysed macroscopically and total number of nutrient foramina for each bone was recorded. Total length of each bone within a group was recorded. Statistical analysis was performed to determine correlation between total bone length and number of nutrient foramina, by using SPSS version 17.0 for Windows. Results: A statistically significant negative correlations between the left humerus length and the number of NF was found. A positive correlations between the length of the right radius and the number of NF, the left ulna length and the number of NF, the right ulna length and the number of NF were found. A negative correlations between the length of the left radius and the number of NF and between right humerus length and number of NF were found. A positive correlation between the length of the right and left femur and the number of NF were found. A negative correlation between the length of left tibia and the number of NF was found, as well as negative correlation between the length of right and left fibula and number of NF. Conclusion: Total bone length is not related to the number of nutrient foramina. The number of nutrient foramina does not depend on the total length of the bone, which is important when assessing the success of grafts for transplantation on long bones in taller people.
    Type of Medium: Online Resource
    ISSN: 2456-9119
    URL: Article
    DOI: 10.9734/jpri/2021/v33i61A35113
    Language: Unknown
    Publisher: Sciencedomain International
    Publication Date: 2021
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  • 4
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    Online Resource
    Increased mean platelet volume is associated with acute myocardial infarction in patients with diabetes mellitus type 2
    Medip Academy ; 2022
    In:  International Journal of Research in Medical Sciences Vol. 10, No. 7 ( 2022-06-28), p. 1426-
    Details
    In: International Journal of Research in Medical Sciences, Medip Academy, Vol. 10, No. 7 ( 2022-06-28), p. 1426-
    Abstract: Background: The correlation between diabetes mellitus and acute myocardial infarction is greater every day. The mean platelet volume (MPV), which is the determinant of platelet function, is an independent risk factor for the cardiovascular disease. The aim of the study was to investigate the effect of each disease (hypothyroidism, hypertension, myocardial infarction) individually and combined on MPV in diabetic patients.Methods: The cross-sectional study included 102 patients who suffer from diabetes mellitus type 2 (DMT2), of both sexes (46 females, 56 males), with the average age of 58.91 (SD=12.93). All the patients were treated at the Primary Health Centre in Zenica from May to July 2017. All patients had diabetes mellitus and the disease had lasted for 10 years in both sexes.Results: Mean platelet volume was significantly higher in patients with myocardial infarction than in those without myocardial infarction. Age, sex, HbA1c, BMI, lipids and platelet count did not show any significance in either group of patients. Regression analysis showed that the prevalence of myocardial infarction had the highest predictive significance for MPV values, (predictor importance 0.49; coefficient 1.275, p 〈 0.001).Conclusions: Mean platelet volume was significantly higher in patients with diabetes mellitus and myocardial infarction than in DM patients without myocardial infarction. Regression analysis showed correlation with acute myocardial infarction in patients with DMT2, but not with other chronic illnesses. The highest platelet volume indices were observed in patients with myocardial infarction. MPV can be used as a specific indicator in diabetic patients with myocardial infarction.   
    Type of Medium: Online Resource
    ISSN: 2320-6012 , 2320-6071
    URL: Article
    DOI: 10.18203/2320-6012.ijrms20221784
    Language: Unknown
    Publisher: Medip Academy
    Publication Date: 2022
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  • 5
    Online Resource
    Online Resource
    Morphological changes in myocardium of Wistar rat caused by hyperthermia
    Elsevier BV ; 2023
    In:  Journal of King Saud University - Science Vol. 35, No. 2 ( 2023-02), p. 102473-
    Details
    In: Journal of King Saud University - Science, Elsevier BV, Vol. 35, No. 2 ( 2023-02), p. 102473-
    Type of Medium: Online Resource
    ISSN: 1018-3647
    URL: Article
    DOI: 10.1016/j.jksus.2022.102473
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2023
    detail.hit.zdb_id: 2514731-6
    SSG: 11
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  • 6
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    Online Resource
    Influence of the Optic Disc Size on Cup Diameter in Patients with Glaucoma Simplex Chronicum
    ScopeMed ; 2013
    In:  Medical Archives Vol. 67, No. 4 ( 2013), p. 272-
    Details
    In: Medical Archives, ScopeMed, Vol. 67, No. 4 ( 2013), p. 272-
    Type of Medium: Online Resource
    ISSN: 0350-199X
    URL: Journal
    URL: Article
    DOI: 10.5455/medarh.
    DOI: 10.5455/medarh.2013.67.272-274
    Language: Unknown
    Publisher: ScopeMed
    Publication Date: 2013
    detail.hit.zdb_id: 2676157-9
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  • 7
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    Online Resource
    Poikilocytotic forms caused by hyperthermia and heat stroke- experimental study on Wistar rats
    Medip Academy ; 2022
    In:  International Journal of Research in Medical Sciences Vol. 10, No. 6 ( 2022-05-27), p. 1225-
    Details
    In: International Journal of Research in Medical Sciences, Medip Academy, Vol. 10, No. 6 ( 2022-05-27), p. 1225-
    Abstract: Background: The aim of the study was to find out what happens to erythrocytes and their forms during life and after death as a result of high water temperature.Methods: Heat stress was used on a rat model.to investigate the effects of different temperature intensities (37°C and 44°C) and exposure time (20 min and until the time of death) on erythrocyte morphology. Total of 23 Wistar rats were divided into two groups: 37°C as control group and 44°C as trial groups. The trial groups were classified into antemortem the exposure time of 20 min and postmortem groups exposure time until fatal outcome. The anaesthetised rats were exposed to preheated water using the water bath. May-Grünwald-Giemsa colouring technique was applied on blood samples taken from the abdominal aorta. Results: Exposure of Wistar rats to water temperature in groups KG37 and G44 led to a significant changes in core temperature. In the control group, the thermoregulatory mechanism established normothermia, and in G44 hyperthermia was detected during 20 minutes of exposure. The frequency of heat stroke in group G44 was 43.8%. Target cells and anulocytes were predominant in antemortem group at 44°C, while anulocytes and spherocytes in postmortem groups 44°C, respectively. Dacryocytes with spherocytes were significantly higher in postmortem group 44°C than in antemortem group 44°C (p=0.002, p=0.017, respectively).Conclusions: Poikilocytosis is associated with the exposure length and temperature intensity. Following a fatal outcome dacryocytes with spherocytes at 44°C were significantly more than in corresponding antemortem groups.
    Type of Medium: Online Resource
    ISSN: 2320-6012 , 2320-6071
    URL: Article
    DOI: 10.18203/2320-6012.ijrms20221476
    Language: Unknown
    Publisher: Medip Academy
    Publication Date: 2022
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  • 8
    Online Resource
    Online Resource
    A Geometric Morphometrics Approach for Sex Estimation Based on the Orbital Region of Human Skulls from Bosnian Population
    Hindawi Limited ; 2023
    In:  Scanning Vol. 2023 ( 2023-4-14), p. 1-9
    Details
    In: Scanning, Hindawi Limited, Vol. 2023 ( 2023-4-14), p. 1-9
    Abstract: Background. Understanding the anatomy and morphological variability of the orbital region is of great importance in clinical practice, forensic medicine, and biological anthropology. Several methods are used to estimate sex based on the skeleton or parts of the skeleton: classic methods and the geometric morphometric method. The objective of this research was to analyse sex estimation of the orbital region on a sample of skulls from a Bosnian population using the geometric morphometric method. Materials and Methods. The research was conducted on three-dimensional models of 211 human adult skulls (139 males and 72 females) from the Osteological Collection at the Faculty of Medicine in Sarajevo. The skulls were recorded using a laser scanner to obtain skull 3D models. We marked 12 landmarks on each model to analyse sexual dimorphism. Landmarks were marked using the program Landmark Editor. After marking the landmarks, we used the MorphoJ program to analyse the morphological variability between male and female orbital regions. Results. After Procrustes superimposition, generating a covariant matrix, and introducing sex as a variable for classification, a discriminant functional analysis (DFA) was applied which determined the estimation for males with 86.33% accuracy and for females with 88.89% based on the form of the orbital region. The results of regression analysis showed that the size of the orbital region has a statistically significant effect on its shape’s sexual dimorphism. After excluding the influence of size and providing DFA, we concluded that sex estimation was possible with 82.01% accuracy for males and 80.55% accuracy for females based on the shape of the orbital region in the examined sample. Conclusion. Sex estimation based on the orbital region was possible with more than 80% accuracy for both sexes, which is a high percentage of correct estimation. Therefore, we recommend using the orbital region of the skull for sex estimation.
    Type of Medium: Online Resource
    ISSN: 1932-8745 , 0161-0457
    URL: Article
    DOI: 10.1155/2023/2223138
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2023
    detail.hit.zdb_id: 1497198-7
    SSG: 11
    SSG: 12
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  • 9
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    Online Resource
    Correlation between diabetic nephropathy and diabetic retinopathy as a long term complications of diabetes mellitus
    Walter de Gruyter GmbH ; 2023
    In:  Acta Marisiensis - Seria Medica Vol. 69, No. 3 ( 2023-09-01), p. 176-181
    Details
    In: Acta Marisiensis - Seria Medica, Walter de Gruyter GmbH, Vol. 69, No. 3 ( 2023-09-01), p. 176-181
    Abstract: Background/aim : Diabetes mellitus is a metabolic disorder of multiple etiologies characterized by a lack of insulin, with a consequent disordered metabolism of glucose, fats, and proteins. A number of complications, such as diabetic nephropathy and retinopathy, may develop as a result of long-term diabetes. The aim of this study aimed to determine the correlation between diabetic nephropathy and diabetic retinopathy as long-term complications of diabetes mellitus. Materials and methods : Retrospective, descriptive, and analytical research was conducted at the department of Endocrinology, Clinical Center, University of Sarajevo. The study included 158 patients hospitalized in time between 1st of January and 31st of December 2012. Results : New-onset diabetes was found in 38%, and diabetes type 2 patients 132 (83.5%), female 105 (66.5%) while older than 60 years were 100 (63.3%). Upon discharge from hospital 83,7% of patients were discharged with glycemia 〈 10 mmol / l. We found that 47,5% of patients had HbA1c 〉 10%. Reduced kidney function, different degrees of failure was at 66.5%. More than half (62.7%) patients had proteinuria as a sign of diabetic nephropathy. Diabetic retinopathy was diagnosed with different types in 54.4%. Conclusion : Diabetes leads to an increase in nitrogen compounds, and the development of diabetic nephropathy manifests as various degrees of renal insufficiency. The duration of diabetes and occurrence of diabetic retinopathy were significantly interrelated. The correlation between the degree of renal failure and changes in the ocular fundus has not been proven, but more severe renal insufficiency is associated with a higher incidence of diabetic retinopathy compared to patients with less impaired renal function.
    Type of Medium: Online Resource
    ISSN: 2668-7763
    URL: Article
    DOI: 10.2478/amma-2023-0024
    Language: English
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2023
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  • 10
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    Online Resource
    Multiorgan morphological changes caused by hyperthermia: Case study on experimental model
    Walter de Gruyter GmbH ; 2023
    In:  Acta Marisiensis - Seria Medica Vol. 69, No. 3 ( 2023-09-01), p. 220-225
    Details
    In: Acta Marisiensis - Seria Medica, Walter de Gruyter GmbH, Vol. 69, No. 3 ( 2023-09-01), p. 220-225
    Abstract: Morphologic changes in organs vary from nonspecific to specific ones, depending on causes of sudden death, e.i whether it is an acute, subacute or chronic event. The aim of this pilot study was to observe the appearance and occurrence of morphological characteristics on organs that were exposed to long-term effects of hyperthermia. A sample of 7 rats was exposed to a water temperature of 41 °C, which is defined in the literature as “heat stroke temperature”, both sexes, weighing 250 to 300 g were used. Tissue samples, obtained by dissection of rats, were fixed in 10% buffered neutral formalin, at room temperature, then incorporated into paraffin blocks, cut at 4-5 microns, mounted and stained with standard hematoxylin-eosin (HE) method. In order to prove/exclude lipid and glycogen accumulation in hepatocytes we did additional histochemical staining, using Sudan black and Periodic Acid Shiff (PAS) method, respectively. We obtained samples from kidney, liver, pancreas, spleen, lung and brain. Analyzing tissue samples of different organs obtained from seven Wistar rats, we gained insight into morphological changes caused by induced hyperthermia. All sampled organs showed congestion and some degree of oedema. The most prominent changes were observed in liver and lung samples. Tissue samples of the lung of all seven rats showed signs of acute bronchitis and bronchiolitis, together with signs of initial bronchopneumonia. We also noticed signs of focal acute emphysema as well as focal accumulations of foamy macrophages. Our study suggests that changes in the vascular bed occur soon after hyperthermia and while some organs are more tolerant to heat stroke than others, most organs show similar changes consisting of capillary dilation, congestion and interstitial extravasation, observed after 30 minutes at a temperature of 40.5 °C, with the most significant changes observed in liver and lung samples.
    Type of Medium: Online Resource
    ISSN: 2668-7763
    URL: Article
    DOI: 10.2478/amma-2023-0026
    Language: English
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2023
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