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  • 1
    Online Resource
    Online Resource
    American Geophysical Union (AGU) ; 2015
    In:  Journal of Geophysical Research: Biogeosciences Vol. 120, No. 2 ( 2015-02), p. 254-269
    In: Journal of Geophysical Research: Biogeosciences, American Geophysical Union (AGU), Vol. 120, No. 2 ( 2015-02), p. 254-269
    Abstract: A survey of peat initiation and climatic determinants is presented Model of peat accumulation simulates bistable behavior in peat thickness Fewer regions of persistent peats between 4.5 and 3.5 kyr caused by local topography
    Type of Medium: Online Resource
    ISSN: 2169-8953 , 2169-8961
    URL: Issue
    Language: English
    Publisher: American Geophysical Union (AGU)
    Publication Date: 2015
    detail.hit.zdb_id: 3094167-2
    detail.hit.zdb_id: 2220777-6
    SSG: 16,13
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  • 2
    In: Earth System Dynamics, Copernicus GmbH, Vol. 9, No. 1 ( 2018-01-31), p. 103-118
    Abstract: Abstract. We present a new framework for modelling the complexities of food and water security under globalisation. The framework sets out a method to capture regional and sectoral interdependencies and cross-scale feedbacks within the global food system that contribute to emergent water use patterns. The framework integrates aspects of existing models and approaches in the fields of hydrology and integrated assessment modelling. The core of the framework is a multi-agent network of city agents connected by infrastructural trade networks. Agents receive socio-economic and environmental constraint information from integrated assessment models and hydrological models respectively and simulate complex, socio-environmental dynamics that operate within those constraints. The emergent changes in food and water resources are aggregated and fed back to the original models with minimal modification of the structure of those models. It is our conviction that the framework presented can form the basis for a new wave of decision tools that capture complex socio-environmental change within our globalised world. In doing so they will contribute to illuminating pathways towards a sustainable future for humans, ecosystems and the water they share.
    Type of Medium: Online Resource
    ISSN: 2190-4987
    Language: English
    Publisher: Copernicus GmbH
    Publication Date: 2018
    detail.hit.zdb_id: 2578793-7
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  • 3
    Online Resource
    Online Resource
    Public Library of Science (PLoS) ; 2011
    In:  PLoS ONE Vol. 6, No. 9 ( 2011-9-8), p. e24635-
    In: PLoS ONE, Public Library of Science (PLoS), Vol. 6, No. 9 ( 2011-9-8), p. e24635-
    Type of Medium: Online Resource
    ISSN: 1932-6203
    Language: English
    Publisher: Public Library of Science (PLoS)
    Publication Date: 2011
    detail.hit.zdb_id: 2267670-3
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  • 4
    In: Sustainability Science, Springer Science and Business Media LLC, Vol. 18, No. 3 ( 2023-05), p. 1481-1500
    Abstract: Arctic food systems are increasingly challenged by rapid climate change, loss of food security and subsequent weakening of food sovereignty, and destabilization of Indigenous practices. Despite growing scientific knowledge on Arctic food systems, Indigenous communities continue to struggle with a plethora of sustainability challenges. To develop a systemic understanding of these challenges, we performed a systematic review of 526 articles published between 1998 and 2021 on Arctic Indigenous food systems. We used the leverage points framework to structure our analysis to understand to what extent the existing Western scientific body of literature provides the necessary knowledge to understand the food system characteristics that give rise to the current sustainability challenges. We combined deductive qualitative and inductive quantitative approaches to identify gaps in the systemic understanding of Arctic Indigenous food systems. We characterized existing research across the four levels of systemic depth—parameters, feedbacks, design, intent—and identified promising directions for future research. Our analyses show that research on food systems is clustered within six main domains, we term environmental contaminants, diet and health, food security, food culture and economy, changing socio-ecological systems and marine and coast. Based on our analysis, we identify three directions for future research that we believe to be of particular importance to enable sustainability transformations of Arctic Indigenous food systems: (i) the decolonization of research practices, (ii) acknowledging the significance of systemic interdependencies across shallow and deep leverage points, and (iii) transdisciplinary action-oriented research collaborations directing transformative system interventions.
    Type of Medium: Online Resource
    ISSN: 1862-4065 , 1862-4057
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2260333-5
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  • 5
    Online Resource
    Online Resource
    Elsevier BV ; 2012
    In:  Quaternary International Vol. 279-280 ( 2012-11), p. 116-
    In: Quaternary International, Elsevier BV, Vol. 279-280 ( 2012-11), p. 116-
    Type of Medium: Online Resource
    ISSN: 1040-6182
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2012
    detail.hit.zdb_id: 2002133-1
    detail.hit.zdb_id: 1077692-8
    SSG: 13
    SSG: 14
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  • 6
    In: Journal of Virology, American Society for Microbiology, Vol. 91, No. 1 ( 2017-01)
    Abstract: Zika virus (ZIKV; family Flaviviridae , genus Flavivirus ) is a rapidly expanding global pathogen that has been associated with severe clinical manifestations, including devastating neurological disease in infants. There are currently no molecular clones of a New World ZIKV available that lack significant attenuation, hindering progress toward understanding determinants of transmission and pathogenesis. Here we report the development and characterization of a novel ZIKV reverse genetics system based on a 2015 isolate from Puerto Rico (PRVABC59). We generated a two-plasmid infectious clone system from which infectious virus was rescued that replicates in human and mosquito cells with growth kinetics representative of wild-type ZIKV. Infectious clone-derived virus initiated infection and transmission rates in Aedes aegypti mosquitoes comparable to those of the primary isolate and displayed similar pathogenesis in AG129 mice. This infectious clone system provides a valuable resource to the research community to explore ZIKV molecular biology, vaccine development, antiviral development, diagnostics, vector competence, and disease pathogenesis. IMPORTANCE ZIKV is a rapidly spreading mosquito-borne pathogen that has been linked to Guillain-Barré syndrome in adults and congenital microcephaly in developing fetuses and infants. ZIKV can also be sexually transmitted. The viral molecular determinants of any of these phenotypes are not well understood. There is no reverse genetics system available for the current epidemic virus that will allow researchers to study ZIKV immunity, develop novel vaccines, or develop antiviral drugs. Here we provide a novel infectious clone system generated from a recent ZIKV isolated from a patient infected in Puerto Rico. This infectious clone produces virus with in vitro and in vivo characteristics similar to those of the primary isolate, providing a critical tool to study ZIKV infection and disease.
    Type of Medium: Online Resource
    ISSN: 0022-538X , 1098-5514
    Language: English
    Publisher: American Society for Microbiology
    Publication Date: 2017
    detail.hit.zdb_id: 1495529-5
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  • 7
    Online Resource
    Online Resource
    Public Library of Science (PLoS) ; 2019
    In:  PLOS ONE Vol. 14, No. 3 ( 2019-3-26), p. e0213378-
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  • 8
    In: BMC Nutrition, Springer Science and Business Media LLC, Vol. 9, No. 1 ( 2023-08-26)
    Abstract: The present-day food system is a key driver of climate change and biodiversity loss, making it imperative for populations to shift towards more sustainable diets. The involvement of youth in this transition is vital because they are in a formative period where their identities, values, and norms, including their food behaviours, are being shaped. Special attention should be paid to youth in practical education because they are often overlooked in existing studies, yet evidence suggests they may lack the necessary resources to support dietary changes, resulting in lower levels of pro-environmental food-related behaviours. The aim of the FLY (Food-related Lifestyles in Youth) project is to study how sustainable food-related lifestyles and underlying factors develop in early adolescence, particularly in Dutch youth in practical education, how these spread in social networks, and to develop community-level intervention strategies to support youths’ transition to sustainable food-related behaviours. Methods/design The FLY-project adopts a mixed-method approach. First, two literature reviews are conducted. A systematic review assesses how capabilities, opportunities and motivation are associated with sustainable food behaviours in youth, and how these elements interrelate in determining sustainable food-related lifestyles. A scoping review studies community-level interventions that target sustainable and healthy food-related behaviours. Second, focus groups are conducted to explore the barriers and facilitating factors concerning capabilities, opportunities, and motivations that Dutch youth in practical-level education experience to transition to more sustainable food-related lifestyles. Third, a cohort survey study is conducted to track the dynamic interplay between capabilities, opportunities, motivation, and changes in specific sustainable food behaviours over time, and to assess the diffusion of sustainable food-related lifestyles via social (media) networks. Fourth, an experimental research programme tests promising intervention approaches, some of which are co-created with youth, targeting relevant underlying factors. Discussion This paper describes the rationale, conceptual framework, design and methods of the FLY-project. The FLY-project contributes to an understanding of underlying factors of sustainable food-related behaviours in adolescence and results in a multi-component intervention toolkit, with a particular focus on youth in practical education programmes.
    Type of Medium: Online Resource
    ISSN: 2055-0928
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2809847-X
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  • 9
    In: mBio, American Society for Microbiology, Vol. 10, No. 2 ( 2019-04-30)
    Abstract: Interferons (IFNs) and autophagy are critical neuronal defenses against viral infection. IFNs alter neuronal autophagy by promoting the accumulation of IFN-dependent LC3-decorated autophagic structures, termed LC3 clusters. Here, we analyzed LC3 clusters in sensory ganglia following herpes simplex virus 1 (HSV-1) infection. In the vicinity of acutely infected neurons, antigen-negative neurons contained structures resembling accumulated autophagosomes and autolysosomes that culminated in LC3 clusters. This accumulation reflects a delayed completion of autophagy. The e ndosomal s orting c omplexes r equired for t ransport (ESCRT) machinery participates in autophagosome closure and is also required for HSV-1 replication. In this study, our results showed that HSV-1 infection in vivo and in primary neurons caused a decrease in Vps4 (a key ESCRT pathway ATPase) RNA and protein with concomitant Stat1 activation and LC3 cluster induction. We also observed that IFNs were sufficient to decrease RNA and protein levels of Vps4 in primary neurons and in other cell types. The accumulation of ubiquitin was also observed at the LC3 cluster sites. Together, our results show that IFNs modulate the ESCRT machinery in neurons in response to HSV-1 infections. IMPORTANCE Neurons rely on IFNs and autophagy as major defenses against viral infections, and HSV must overcome such defenses in order to replicate. In addition to controlling host immunity, HSV must also control host membranes in order to complete its life cycle. HSV uses the host ESCRT membrane scission machinery for viral production and transport. Here we present evidence of a new IFN-dependent mechanism used by the host to prevent ESCRT subversion by HSV. This activity also impacts the dynamics of autophagy, possibly explaining the presence of recently described LC3 clusters in the HSV-infected nervous system. The induced accumulations of ubiquitin observed in these LC3 clusters resembled those observed in certain neurodegenerative diseases, suggesting possible mechanistic parallels between these conditions.
    Type of Medium: Online Resource
    ISSN: 2161-2129 , 2150-7511
    Language: English
    Publisher: American Society for Microbiology
    Publication Date: 2019
    detail.hit.zdb_id: 2557172-2
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  • 10
    Online Resource
    Online Resource
    Copernicus GmbH ; 2018
    In:  Climate of the Past Vol. 14, No. 8 ( 2018-08-20), p. 1253-1273
    In: Climate of the Past, Copernicus GmbH, Vol. 14, No. 8 ( 2018-08-20), p. 1253-1273
    Abstract: Abstract. The impact of climate change on the development and disintegration of Maya civilisation has long been debated. The lack of agreement among existing palaeoclimatic records from the region has prevented a detailed understanding of regional-scale climatic variability, its climatic forcing mechanisms and its impact on the ancient Maya. We present two new palaeo-precipitation records for the central Maya lowlands, spanning the Pre-Classic period (1800 BCE–250 CE), a key epoch in the development of Maya civilisation. A beach ridge elevation record from world's largest late Holocene beach ridge plain provides a regional picture, while Lake Tuspan's diatom record is indicative of precipitation changes at a local scale. We identify centennial-scale variability in palaeo-precipitation that significantly correlates with the North Atlantic δ14C atmospheric record, with a comparable periodicity of approximately 500 years, indicating an important role of North Atlantic atmospheric–oceanic forcing on precipitation in the central Maya lowlands. Our results show that the Early Pre-Classic period was characterised by relatively dry conditions, shifting to wetter conditions during the Middle Pre-Classic period, around the well-known 850 BCE (2.8 ka) event. We propose that this wet period may have been unfavourable for agricultural intensification in the central Maya lowlands, explaining the relatively delayed development of Maya civilisation in this area. A return to relatively drier conditions during the Late Pre-Classic period coincides with rapid agricultural intensification in the region and the establishment of major cities.
    Type of Medium: Online Resource
    ISSN: 1814-9332
    Language: English
    Publisher: Copernicus GmbH
    Publication Date: 2018
    detail.hit.zdb_id: 2217985-9
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