In:
CURRENT TOPICS IN NUTRACEUTICAL RESEARCH, New Century Health Publishers LLC, Vol. 21, No. 4 ( 2023-10-09), p. 332-338
Abstract:
We have investigated the role of Esculentoside A in the progression of carbapenem-resistant Klebsiella pneumoniae infection in Human MLE-12 cells. The results of the studies show that Esculentoside A enhances the viability of carbapenem-resistant Klebsiella pneumoniae-infected MLE-12 cells and suppresses cell apoptosis. EsA also suppresses mitochondrial damage and oxidative stress in lung epithelial cells caused by carbapenem-resistant Klebsiella pneumoniae infections. The data further confirmed that Esculentoside A could relieve mitochondrial damage, apoptosis, and oxidative stress in carbapenem-resistant Klebsiella pneumonia-infected lung epithelial cells by regulating the mitogen-activated protein kinase pathway.
Type of Medium:
Online Resource
ISSN:
1540-7535
,
2641-452X
DOI:
10.37290/ctnr2641-452X.21:332-338
Language:
Unknown
Publisher:
New Century Health Publishers LLC
Publication Date:
2023
detail.hit.zdb_id:
2455097-8
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