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  • 1
    Online Resource
    Online Resource
    Excessive apoptosis of Rip1 ‐deficient T cells leads to premature aging
    EMBO ; 2023
    In:  EMBO reports Vol. 24, No. 12 ( 2023-12-06)
    Details
    In: EMBO reports, EMBO, Vol. 24, No. 12 ( 2023-12-06)
    Abstract: image T‐cell specific Rip1 KO mice show signs of accelerated aging‐like phenotypes, along with premature death. Blocking apoptosis by co‐deleting Fadd in Rip1 tKO mice significantly rescues aging‐like phenotypes and prolongs shortened lifespan. Rip1 tKO mice show similar age‐related T cell changes and exhibit signs of accelerated aging and a shorter lifespan. Rip1 ‐deficient T cells undergo excessive apoptosis, promoting chronic inflammation. Blocking necroptosis has little effect on the multimorbidity and premature aging seen in Rip1 tKO mice. Blocking T cell apoptosis by co‐deleting Fadd rescues premature aging and multimorbidity in Rip1 tKO mice.
    Type of Medium: Online Resource
    ISSN: 1469-221X , 1469-3178
    URL: Article
    DOI: 10.15252/embr.202357925
    Language: English
    Publisher: EMBO
    Publication Date: 2023
    detail.hit.zdb_id: 2025376-X
    SSG: 12
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  • 2
    Online Resource
    Online Resource
    The Expression of Snail, Galectin-3, and IGF1R in the Differential Diagnosis of Benign and Malignant Pheochromocytoma and Paraganglioma
    Hindawi Limited ; 2020
    In:  BioMed Research International Vol. 2020 ( 2020-02-29), p. 1-10
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2020 ( 2020-02-29), p. 1-10
    Abstract: Objective . The aim of this study was to investigate the expression of Snail, galectin-3, and IGF1R in benign and malignant pheochromocytoma and paraganglioma (PPGL) and explore their role in the diagnosis of malignant PPGL. Methods . We retrospectively collected and analyzed surgical tumor tissue from 226 patients initially diagnosed with PPGL who underwent surgery from Jan. 2009 to Jan. 2016 at West China Hospital, Sichuan University. We observed and quantified the expression of Snail, galectin-3, and IGF1R in paraffin-embedded samples by immunohistochemical staining. Results . The significant difference in survival time among the three groups (benign PHEO, benign PGL, and potentially malignant PPGL) was compared by Kaplan-Meier survival analysis. The positive staining of Snail, galectin-3, and IGF1R in the benign PHEO group was significantly lower than that in the other three groups ( P 〈 0.001 ). The Kaplan-Meier survival plots indicated that the survival time of the patients with intense positive staining was significantly lower than that of the patients with weak positive staining. Conclusion . The intense expression of Snail, galectin-3, and IGF1R may be valuable indicators for the diagnosis of malignant PPGL.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2020/4150735
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2698540-8
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  • 3
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    Online Resource
    Efficacy and safety of heat-sensitive moxibustion in the treatment of ulcerative colitis : A protocol for a systematic review and meta-analysis
    Ovid Technologies (Wolters Kluwer Health) ; 2021
    In:  Medicine Vol. 100, No. 4 ( 2021-01-29), p. e24078-
    Details
    In: Medicine, Ovid Technologies (Wolters Kluwer Health), Vol. 100, No. 4 ( 2021-01-29), p. e24078-
    Abstract: Ulcerative colitis (UC) is a chronic nonspecific intestinal inflammatory disease with unclear etiology occurring in the colonic mucosa. Its clinical manifestations are characterized by recurrent abdominal pain, diarrhea, mucous pus, and blood stool. The severity of the disease varies, and itis characterized by a high recurrence rate. Because of its long course of disease, easy to relapse, protracted and difficult to recover, seriously affect the quality of life, increase the economic burden of patients and society, and even the risk of developing cancer, it has become one of the hot issues of general concern in the medical field. Heat-sensitive moxibustion therapy has shown strong advantages in the treatment of UC, and the curative effect is accurate. therefore, this paper will carry out a systematic evaluation and meta analysis of the efficacy and safety of heat-sensitive moxibustion in the treatment of UC. Methods: We will be searching 8 electronic databases, including PubMed, Embase, Web of Science, Cochrane Library, the China National Knowledge Infrastructure, Chinese Science and Technology Periodical Database, Wanfang Database, and Chinese Biomedical Literature Database. We will search above electronic databases from the beginning to December 2020, without any language restriction. Clinical efficacy, including total effective rate or cure rate, clinical symptom integral (abdominal pain, diarrhea, purulent stool), and recurrence rate will be accepted as the primary outcomes. The changes of cytokine Hs-CRP, IL-6, TNF-αlevels in serum, and improvement of colorectal mucosa will be used as secondary outcomes. RevMan 5.3 software will be used for statistical analysis. The result about the curative effect and safety of heat-sensitive moxibustion for UC will be presented as risk ratio for dichotomous data and mean differences with a 95% confidence interval for continuous data. Results: When this research program is completed, the relevant results can be obtained. Conclusions: The results of this study will provide reliable evidence for the efficacy and safety of heat-sensitive moxibustion in the treatment of UC. INPLASY Registration number: INPLASY20201101034.
    Type of Medium: Online Resource
    ISSN: 0025-7974 , 1536-5964
    URL: Article
    DOI: 10.1097/MD.0000000000024078
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2021
    detail.hit.zdb_id: 2049818-4
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  • 4
    Online Resource
    Online Resource
    A forensic spectroscopic identification analysis on skin evanescent trauma by chemometrics
    Elsevier BV ; 2024
    In:  Vibrational Spectroscopy Vol. 132 ( 2024-05), p. 103687-
    Details
    In: Vibrational Spectroscopy, Elsevier BV, Vol. 132 ( 2024-05), p. 103687-
    Type of Medium: Online Resource
    ISSN: 0924-2031
    URL: Article
    DOI: 10.1016/j.vibspec.2024.103687
    RVK:
    VA 1900.1
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2024
    detail.hit.zdb_id: 1500818-6
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  • 5
    Online Resource
    Online Resource
    The Data Management System of Tunnel Monitoring
    Maxwell Scientific Publication Corp. ; 2013
    In:  Research Journal of Applied Sciences, Engineering and Technology Vol. 6, No. 3 ( 2013-6-15), p. 496-499
    Details
    In: Research Journal of Applied Sciences, Engineering and Technology, Maxwell Scientific Publication Corp., Vol. 6, No. 3 ( 2013-6-15), p. 496-499
    Type of Medium: Online Resource
    ISSN: 2040-7459 , 2040-7467
    URL: Article
    DOI: 10.19026/rjaset.6.4108
    Language: Unknown
    Publisher: Maxwell Scientific Publication Corp.
    Publication Date: 2013
    detail.hit.zdb_id: 2546000-6
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  • 6
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    Online Resource
    Thrombin Induces CCL2 Expression in Human Lung Fibroblasts via p300 Mediated Histone Acetylation and NF‐KappaB Activation
    Wiley ; 2017
    In:  Journal of Cellular Biochemistry Vol. 118, No. 11 ( 2017-11), p. 4012-4019
    Details
    In: Journal of Cellular Biochemistry, Wiley, Vol. 118, No. 11 ( 2017-11), p. 4012-4019
    Abstract: Thrombin has been shown to play a key role in lung diseases such as pulmonary fibrosis via the induction of fibrotic cytokine‐ chemokine (CC motif) ligand‐2 (CCL2) expression. We previously reported that transcription factor nuclear factor‐κB (NF‐κB) is responsible for thrombin‐induced CCL2 expression in human lung fibroblasts (HLFs). Here, we extended our study to investigate the epigenetic regulation mechanism for thrombin‐induced CCL2 expression in HLFs. HLFs were cultured in F‐12 medium. CCL2 protein and mRNA levels were detected by ELISA and quantitative real‐time PCR, respectively. Histone, histone acetyltransferases, and NF‐κB binding to CCL2 promoter were detected by ChIP assay. NF‐κB activation was detected by Western blotting. We revealed that increased binding of histone acetyltransferase p300 and acetylated histone H3 and H4 to CCL2 promoter are responsible for thrombin induced CCL2 expression in HLF cells. In addition, p300 inhibition attenuates both thrombin induced‐CCL2 expression and histone H3 and H4 acetylation in HLFs, suggesting that p300 is involved in thrombin‐induced CCL2 expression via hyperacetylating histone H3 and H4. Our data further showed that p300 also regulates CCL2 expression via interaction with NF‐κB p65, as depletion of p300 inhibits both NF‐κB p65 activation and its binding to CCL2 promoter. The findings strongly suggest that epigenetic dysregulation and the interaction between histone acetyltransferase and transcription factor may be responsible for thrombin induced‐CCL2 expression in HLFs. Increased understanding of the epigenetic mechanisms of CCL2 regulation may provide opportunities for identifying novel molecular targets for therapeutic purposes. J. Cell. Biochem. 118: 4012–4019, 2017. © 2017 Wiley Periodicals, Inc.
    Type of Medium: Online Resource
    ISSN: 0730-2312 , 1097-4644
    URL: Issue
    URL: Article
    DOI: 10.1002/jcb.v118.11
    DOI: 10.1002/jcb.26057
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 1479976-5
    SSG: 12
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  • 7
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    Individualized resuscitation strategy for septic shock formalized by finite mixture modeling and dynamic treatment regimen
    Springer Science and Business Media LLC ; 2021
    In:  Critical Care Vol. 25, No. 1 ( 2021-07-12)
    Details
    In: Critical Care, Springer Science and Business Media LLC, Vol. 25, No. 1 ( 2021-07-12)
    Abstract: Septic shock comprises a heterogeneous population, and individualized resuscitation strategy is of vital importance. The study aimed to identify subclasses of septic shock with non-supervised learning algorithms, so as to tailor resuscitation strategy for each class. Methods Patients with septic shock in 25 tertiary care teaching hospitals in China from January 2016 to December 2017 were enrolled in the study. Clinical and laboratory variables were collected on days 0, 1, 2, 3 and 7 after ICU admission. Subclasses of septic shock were identified by both finite mixture modeling and K -means clustering. Individualized fluid volume and norepinephrine dose were estimated using dynamic treatment regime (DTR) model to optimize the final mortality outcome. DTR models were validated in the eICU Collaborative Research Database (eICU-CRD) dataset. Results A total of 1437 patients with a mortality rate of 29% were included for analysis. The finite mixture modeling and K -means clustering robustly identified five classes of septic shock. Class 1 (baseline class) accounted for the majority of patients over all days; class 2 (critical class) had the highest severity of illness; class 3 (renal dysfunction) was characterized by renal dysfunction; class 4 (respiratory failure class) was characterized by respiratory failure; and class 5 (mild class) was characterized by the lowest mortality rate (21%). The optimal fluid infusion followed the resuscitation/de-resuscitation phases with initial large volume infusion and late restricted volume infusion. While class 1 transitioned to de-resuscitation phase on day 3, class 3 transitioned on day 1. Classes 1 and 3 might benefit from early use of norepinephrine, and class 2 can benefit from delayed use of norepinephrine while waiting for adequate fluid infusion. Conclusions Septic shock comprises a heterogeneous population that can be robustly classified into five phenotypes. These classes can be easily identified with routine clinical variables and can help to tailor resuscitation strategy in the context of precise medicine.
    Type of Medium: Online Resource
    ISSN: 1364-8535
    URL: Article
    DOI: 10.1186/s13054-021-03682-7
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2051256-9
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  • 8
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    Online Resource
    Drought impacts on blue and green water: A spatial and temporal analysis
    Elsevier BV ; 2024
    In:  Ecological Indicators Vol. 158 ( 2024-01), p. 111319-
    Details
    In: Ecological Indicators, Elsevier BV, Vol. 158 ( 2024-01), p. 111319-
    Type of Medium: Online Resource
    ISSN: 1470-160X
    URL: Article
    DOI: 10.1016/j.ecolind.2023.111319
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2024
    detail.hit.zdb_id: 2063587-4
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  • 9
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    Online Resource
    The spin caloritronic transport properties of newly designed devices consisting of a sawtooth graphene nanoribbon and its derived five-member ring structure
    Royal Society of Chemistry (RSC) ; 2023
    In:  Physical Chemistry Chemical Physics Vol. 25, No. 24 ( 2023), p. 16578-16586
    Details
    In: Physical Chemistry Chemical Physics, Royal Society of Chemistry (RSC), Vol. 25, No. 24 ( 2023), p. 16578-16586
    Abstract: Achieving high spin polarization transport and a pure spin current is particularly desired in spintronics. We use a sawtooth graphene nanoribbon (STGNR) and its derived five-member ring structure (5-STGNR) to design new spin caloritronic devices, since they have been successfully prepared experimentally and have an interface with no lattice distortion. By using first-principle calculations combined with the non-equilibrium Green's function approach, we have studied the spin caloritronic transport properties of several STGNR-based devices, including the structures with symmetrical and asymmetrical edges, and found some excellent spin caloritronic properties, such as spin polarization, magnetoresistance and the spin Seebeck effect. By introducing a temperature difference, giant magnetoresistance and spin Seebeck effects are achieved in a heterojunction with a symmetrical edge, whereas spin polarization is more effective in a heterojunction with an asymmetrical edge. Meanwhile, the metal–semiconductor–metal junction, which is composed of STGNRs with a symmetrical edge, exhibits approximately 100% spin polarization and produces a perfect thermally induced pure spin current at room temperature. Our results indicate that the devices consisting of a sawtooth graphene nanoribbon and its derived five-member ring structure are promising novel spin caloritronic devices.
    Type of Medium: Online Resource
    ISSN: 1463-9076 , 1463-9084
    URL: Article
    DOI: 10.1039/D3CP00948C
    Language: English
    Publisher: Royal Society of Chemistry (RSC)
    Publication Date: 2023
    detail.hit.zdb_id: 1476283-3
    detail.hit.zdb_id: 1476244-4
    detail.hit.zdb_id: 1460656-2
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  • 10
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    Online Resource
    Effects of Dietary Supplementation of Chinese Yam Polysaccharide on Carcass Composition, Meat Quality, and Antioxidant Capacity in Broilers
    MDPI AG ; 2023
    In:  Animals Vol. 13, No. 3 ( 2023-01-31), p. 503-
    Details
    In: Animals, MDPI AG, Vol. 13, No. 3 ( 2023-01-31), p. 503-
    Abstract: The study aimed to evaluate the influences of the dietary supplementation of Chinese yam polysaccharide (CYP) on the carcass performance, antioxidant capacity, and meat quality of broilers. Three hundred and sixty healthy 1-day-old broilers with similar body weight (39 ± 1 g, gender balanced) were randomly divided into four groups (control, CYP1, CYP2, and CYP3 groups). In the control group, broilers were fed a basal diet with CYP, and the CYP1, CYP2, and CYP3 groups were fed diets supplemented with 250, 500, and 1000 mg/kg CYP, respectively. There were three replicates in each group, 30 birds in each replicate, and the feeding trial lasted for 48 days. Statistical analysis was performed using SPSS 17.0 (SPSS Inc., Chicago, IL, USA) by one-way analysis of variance. The results showed that compared with the control group, dietary supplementation with 500 mg/kg CYP can improve live weight, half-eviscerated carcass percentage, eviscerated carcass percentage, and thigh muscle percentage. Moreover, dietary supplementation with 500 mg/kg CYP can improve the contents of total antioxidant capacity (T-AOC), total superoxide dismutase (T-SOD), glutathione peroxidase (GPX), and glutathione s-transferase (GST) in serum (p 〈 0.05). Meanwhile, the mRNA expression levels of nuclear factor-erythroid 2-related factor 2 (Nrf2), heme oxygenase 1 (HO-1), quinone oxidoreductase (NQO1), superoxide dismutase 1 (SOD1), glutathione peroxidase 1 (GPX1), and catalase (CAT) in the liver; the mRNA expression levels of HO-1, NQO1, GPX1, and CAT in the breast muscle; and the mRNA expression levels of NQO1, SOD1, and CAT in the thigh muscle of broilers in the CYP2 group were significantly increased (p 〈 0.05). In addition, the yellowness and shear force of the thigh and breast muscles and the content of malondialdehyde (MDA) in the serum of broilers in the control group were higher than that in the CYP2 groups (p 〈 0.05). The results demonstrated that the CYP2 group had the best effect on improving meat quality. In conclusion, dietary supplementation with 500 mg/kg CYP can improve the meat quality of broilers by improving carcass quality, meat color, shear force, and antioxidant capacity.
    Type of Medium: Online Resource
    ISSN: 2076-2615
    URL: Article
    DOI: 10.3390/ani13030503
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2606558-7
    SSG: 23
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