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  • 1
    Online Resource
    Online Resource
    Experimental Study on Explosion Pressure and Rock Breaking Characteristics under Liquid Carbon Dioxide Blasting
    Hindawi Limited ; 2018
    In:  Advances in Civil Engineering Vol. 2018 ( 2018-08-27), p. 1-9
    Details
    In: Advances in Civil Engineering, Hindawi Limited, Vol. 2018 ( 2018-08-27), p. 1-9
    Abstract: A liquid carbon dioxide blasting experiment was carried out under free field conditions, alongside a liquid carbon dioxide rock breaking experiment, to investigate explosion pressure variation and rock breaking characteristics under liquid carbon dioxide blasting. The experimental results show that the internal and external explosion pressures of the liquid carbon dioxide fracturing devices all rapidly increased at first, before attenuating vibrantly after blasting. When the explosion pressure was raised, the internal explosion pressure increased first exponentially and then linearly, while the external explosion pressure increased exponentially throughout. The duration time of the blasting effect stage was about 45 ms. Under the combined effect of jet impingement and a gas wedge of high-pressure carbon dioxide, the rock is subjected to tensile failure. The impact failure and the “gas wedge effect” of high-pressure carbon dioxide play a key role in the rock breaking of liquid carbon dioxide blasting technology.
    Type of Medium: Online Resource
    ISSN: 1687-8086 , 1687-8094
    URL: Article
    DOI: 10.1155/2018/7840125
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2449760-5
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  • 2
    Online Resource
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    Mitochondrial Dysfunction in Cardiac Arrhythmias
    MDPI AG ; 2023
    In:  Cells Vol. 12, No. 5 ( 2023-02-21), p. 679-
    Details
    In: Cells, MDPI AG, Vol. 12, No. 5 ( 2023-02-21), p. 679-
    Abstract: Electrophysiological and structural disruptions in cardiac arrhythmias are closely related to mitochondrial dysfunction. Mitochondria are an organelle generating ATP, thereby satisfying the energy demand of the incessant electrical activity in the heart. In arrhythmias, the homeostatic supply–demand relationship is impaired, which is often accompanied by progressive mitochondrial dysfunction leading to reduced ATP production and elevated reactive oxidative species generation. Furthermore, ion homeostasis, membrane excitability, and cardiac structure can be disrupted through pathological changes in gap junctions and inflammatory signaling, which results in impaired cardiac electrical homeostasis. Herein, we review the electrical and molecular mechanisms of cardiac arrhythmias, with a particular focus on mitochondrial dysfunction in ionic regulation and gap junction action. We provide an update on inherited and acquired mitochondrial dysfunction to explore the pathophysiology of different types of arrhythmias. In addition, we highlight the role of mitochondria in bradyarrhythmia, including sinus node dysfunction and atrioventricular node dysfunction. Finally, we discuss how confounding factors, such as aging, gut microbiome, cardiac reperfusion injury, and electrical stimulation, modulate mitochondrial function and cause tachyarrhythmia.
    Type of Medium: Online Resource
    ISSN: 2073-4409
    URL: Article
    DOI: 10.3390/cells12050679
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2661518-6
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  • 3
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    Activation of vagovagal reflex prevents hepatic ischaemia–reperfusion‐induced lung injury via anti‐inflammatory and antioxidant effects
    Wiley ; 2021
    In:  Experimental Physiology Vol. 106, No. 11 ( 2021-11), p. 2210-2222
    Details
    In: Experimental Physiology, Wiley, Vol. 106, No. 11 ( 2021-11), p. 2210-2222
    Abstract: What is the central question of this study? Does vagus nerve stimulation have protective effects against both direct liver damage and distant lung injury in a rat model of hepatic ischaemia–reperfusion? What is the main finding and its importance? Vagus nerve stimulation provides protection through anti‐inflammatory and anti‐oxidative stress effects, possibly achieved by the vagovagal reflex. Abstract Hepatic ischaemia–reperfusion (I/R) is not an isolated event; instead, it can result in remote organ dysfunction. The aim of this study was to investigate whether vagus nerve stimulation (VNS) can alleviate hepatic I/R‐induced lung injury and to explore the underlying mechanism. Thirty male Sprague–Dawley rats were randomly allocated into five groups ( n = 6 each): the sham group (without I/R or VNS), the I/R group (hepatic I/R) and three different VNS treatment groups (hepatic I/R plus VNS). The hepatic I/R group was subjected to occlusion of the portal vein and hepatic artery for 1 h, followed by 6 h of reperfusion. The intact afferent and efferent cervical vagus nerves were stimulated throughout the I/R process. During VNS, cervical neural activity was recorded. At the end of the experiment, liver function, the wet‐to‐dry lung weight ratio, histology of the liver and lung and inflammatory/oxidative indices were evaluated. We found that VNS significantly mitigated lung injury, as demonstrated by alleviation of pulmonary oedema and pathological alterations, by limiting inflammatory cytokine infiltration and increasing antioxidant capability. This proof‐of‐concept study suggested that VNS might protect patients from lung injury induced by hepatic I/R related to various circumstances.
    Type of Medium: Online Resource
    ISSN: 0958-0670 , 1469-445X
    URL: Issue
    URL: Article
    DOI: 10.1113/eph.v106.11
    DOI: 10.1113/EP089865
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 1493802-9
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  • 4
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    Brittle Characteristic and Microstructure of Sandstone under Freezing-Thawing Weathering
    Hindawi Limited ; 2020
    In:  Advances in Civil Engineering Vol. 2020 ( 2020-09-21), p. 1-12
    Details
    In: Advances in Civil Engineering, Hindawi Limited, Vol. 2020 ( 2020-09-21), p. 1-12
    Abstract: As an important property of rock material, brittleness plays a vital role in rock engineering. This paper raised the concept of elastic strain energy release rate and proposed an elastic strain energy release rate based brittleness index based on the most acceptable definition of brittleness. Mechanical and Nuclear Magnetic Resonance parameters of sandstone under various Freezing-Thawing (F-T) cycles are also acquired and analyzed. Then, the proposed brittleness index is used to compare with two recently proposed brittleness indices to verify its correctness and applicability. Finally, the brittleness index is applied to evaluate the brittle behavior of F-T cycles treated sandstone under uniaxial compression. The results show that elastic modulus, value of the postpeak modulus, and peak stress decrease with F-T cycles, and the porosity and microstructure develop with F-T cycles. The proposed brittleness index is highly related to F-T cycles, peak stress, porosity, and elastic modulus of sandstone that suffered recurrent F-T cycles. It declines exponentially with F-T cycles and porosity increase while growing exponentially with peak stress and elastic modulus increase.
    Type of Medium: Online Resource
    ISSN: 1687-8086 , 1687-8094
    URL: Article
    DOI: 10.1155/2020/8893278
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2449760-5
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  • 5
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    Online Resource
    Vagus nerve stimulation protects against acute liver injury induced by renal ischemia reperfusion via antioxidant stress and anti-inflammation
    Elsevier BV ; 2019
    In:  Biomedicine & Pharmacotherapy Vol. 117 ( 2019-09), p. 109062-
    Details
    In: Biomedicine & Pharmacotherapy, Elsevier BV, Vol. 117 ( 2019-09), p. 109062-
    Type of Medium: Online Resource
    ISSN: 0753-3322
    URL: Article
    DOI: 10.1016/j.biopha.2019.109062
    RVK:
    XA 10000
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2019
    detail.hit.zdb_id: 1501510-5
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  • 6
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    A potential relationship between gut microbes and atrial fibrillation: Trimethylamine N-oxide, a gut microbe-derived metabolite, facilitates the progression of atrial fibrillation
    Elsevier BV ; 2018
    In:  International Journal of Cardiology Vol. 255 ( 2018-03), p. 92-98
    Details
    In: International Journal of Cardiology, Elsevier BV, Vol. 255 ( 2018-03), p. 92-98
    Type of Medium: Online Resource
    ISSN: 0167-5273
    URL: Article
    DOI: 10.1016/j.ijcard.2017.11.071
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2018
    detail.hit.zdb_id: 1500478-8
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  • 7
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    Genetic variations in STAT4,C2,HLA-DRB1 and HLA-DQ associated with risk of hepatitis B virus-related liver cirrhosis
    Springer Science and Business Media LLC ; 2015
    In:  Scientific Reports Vol. 5, No. 1 ( 2015-11-05)
    Details
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 5, No. 1 ( 2015-11-05)
    Abstract: Recent genome-wide associated studies (GWASs) have revealed several common loci associated with the risk of hepatitis B virus (HBV)- or hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC). We selected 15 single nucleotide polymorphisms (SNPs) identified through GWASs on HBV- or HCV-related HCC and genotyped them in two independent Chinese cohorts of chronic HBV carriers, including 712 LC cases and 2601 controls. The association of each SNP with the risk of HBV-related LC was assessed by meta-analysis of the two cohorts. Of the 12 SNPs reported in HBV-related HCC GWASs, five SNPs (rs7574865 in STAT4 , rs9267673 near C2 , rs2647073 and rs3997872 near HLA-DRB1 and rs9275319 near HLA-DQ ), were found to be significantly associated with the risk of HBV-related LC (rs7574865: P  = 1.79 × 10 −2 , OR = 1.17, 95% CI = 1.03–1.34; rs9267673: P  = 4.91 × 10 −4 , OR = 1.37, 95% CI = 1.15–1.63; rs2647073: P  = 3.53 × 10 −5 , OR = 1.63, 95% CI = 1.29–2.06; rs3997872: P  = 4.22 × 10 −4 , OR = 1.86, 95% CI = 1.32–2.62; rs9275319: P  = 1.30 × 10 −2 , OR = 1.32, 95% CI = 1.06–1.64). However, among the three SNPs associated with the risk of HCV-related HCC in previous GWASs, none of them showed significant association with the risk of HBV-related LC. Our results suggested that genetic variants associated with HBV-related hepatocarcinogenesis may already play an important role in the progression from CHB to LC.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    URL: Article
    DOI: 10.1038/srep16278
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2015
    detail.hit.zdb_id: 2615211-3
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  • 8
    Online Resource
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    P5-108
    Elsevier BV ; 2006
    In:  Heart Rhythm Vol. 3, No. 5 ( 2006-5), p. S296-S297
    Details
    In: Heart Rhythm, Elsevier BV, Vol. 3, No. 5 ( 2006-5), p. S296-S297
    Type of Medium: Online Resource
    ISSN: 1547-5271
    URL: Article
    DOI: 10.1016/j.hrthm.2006.02.886
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2006
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  • 9
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    Epidermal nevus syndrome with the mutation of PTCH1 gene and cerebral infarction: a case report and review of the literature
    Springer Science and Business Media LLC ; 2022
    In:  Journal of Medical Case Reports Vol. 16, No. 1 ( 2022-09-28)
    Details
    In: Journal of Medical Case Reports, Springer Science and Business Media LLC, Vol. 16, No. 1 ( 2022-09-28)
    Abstract: Epidermal nevus syndrome is a group of congenital neuroectodermal and/or mesodermal disorders characterized by the epidermal nevi in common association with cerebral, eye, skeletal, cardiovascular, and renal abnormalities. Epidermal nevus syndrome is a rare syndrome, and epidermal nevus syndrome with the mutation of PTCH1 gene and cerebral infarction is even rarer and has not been reported to the best of our knowledge. Case presentation We report the case of a 10-month-old Chinese female patient who presented to our pediatric neurologic department, University of Wenzhou medical teaching Hospital, Hangzhou. She has mobility disorders on the right limbs and recurrent seizures. She had congenital disorder accompanied by brownish-black and verrucose plaques on the right side of the face as well as extensive brownish-black plaques and brown nevi on the right side of the trunk and the right arm. Epidermal nevus syndrome was diagnosed on the basis of her symptoms. Somatic sebaceous nevi and hypoplastic defects of skin, cerebra, eyes, skeleton, and cardiovascular and renal system were observed. However, in addition to the typical clinical characteristics, the patient also has a mutation (c.109G  〉  T) in PTCH1 gene and cerebral infarction. We present a novel case report and literature review. Conclusion To our knowledge, epidermal nevus syndrome with a mutation of PTCH1 gene and cerebral infarction has not been reported previously. This case report may contribute to characterizing the phenotype of epidermal nevus syndrome, help clinicians be aware of the association of this condition with PTCH1 gene and cerebral infarction, raise clinical suspicion, and improve early therapy.
    Type of Medium: Online Resource
    ISSN: 1752-1947
    URL: Article
    DOI: 10.1186/s13256-022-03547-9
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2269805-X
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  • 10
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    Vagus Nerve Stimulation Ameliorates Renal Ischemia-Reperfusion Injury through Inhibiting NF- κ B Activation and iNOS Protein Expression
    Hindawi Limited ; 2020
    In:  Oxidative Medicine and Cellular Longevity Vol. 2020 ( 2020-02-20), p. 1-8
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2020 ( 2020-02-20), p. 1-8
    Abstract: Objective . In renal ischemia/reperfusion injury (RIRI), nuclear factor κ B (NF- κ B) initiates the expression of multiple genes involved in inflammatory disease. Inhibition of NF- κ B-mediated inducible nitric oxide synthase (iNOS) expression can ameliorate RIRI. Vagus nerve stimulation (VNS) protects against various organs I/R injury. The present study was designed to elucidate the protective effect of VNS on RIRI and its influence on iNOS protein expression. Methods . Eighteen male Sprague-Dawley rats were randomly allocated into the sham group, the I/R group, and the VNS+I/R group, 6 rats per group. An RIRI model was induced by a right nephrectomy and blockade of the left renal pedicle vessels for 45 min. After 6 h of reperfusion, the blood samples and renal samples were collected. The VNS treatment was performed throughout the I/R process in the VNS+I/R group using specific parameters (20 Hz, 0.1 ms in duration, square waves) known to produce a small but reliable bradycardia. Blood was used for evaluation of renal function and inflammatory state. Renal injury was evaluated via TUNEL staining. Renal samples were harvested to evaluate renal oxidative stress, NF- κ B p65 levels, and iNOS protein expression. Results . The VNS treatment reduces serum creatinine (Cr) and blood urea nitrogen (BUN) levels. Simultaneously, the levels of tumor necrosis factor alpha (TNF- α ), interleukin 6 (IL-6), and interleukin 1-beta (IL-1 β ) were significantly increased in the I/R group, but VNS treatment markedly ameliorated this inflammatory response. Furthermore, the VNS ameliorated oxidant stress and renal injury, indicated by a decrease in 3-nitrotyrosine (3-NT) formation and MDA and MPO levels and an increase in the SOD level compared to that in the I/R group. Finally, the VNS also significantly decreases NF- κ B p65, iNOS, and nitrite/nitrate levels compared to that in the I/R group. Conclusion . Our findings indicate that NF- κ B activation increased iNOS expression and promoted RIRI and that VNS treatment attenuated RIRI by inhibiting iNOS expression, oxidative stress, and inflammation via NF- κ B inactivation.
    Type of Medium: Online Resource
    ISSN: 1942-0900 , 1942-0994
    URL: Article
    DOI: 10.1155/2020/7106525
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2455981-7
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