In:
PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 9 ( 2022-9-30), p. e0268720-
Abstract:
Alternating Hemiplegia of Childhood (AHC) is characterised by paroxysmal hemiplegic episodes and seizures. Remission of hemiplegia upon sleep is a clinical diagnostic feature of AHC. We investigated whether: 1) Hemiplegic events are associated with spectral EEG changes 2) Sleep in AHC is associated with clinical or EEG spectral features that may explain its restorative effect. Methods We retrospectively performed EEG spectral analysis in five adults with AHC and twelve age-/gender-matched epilepsy controls. Five-minute epochs of hemiplegic episodes and ten-minute epochs of four sleep stages were selected from video-EEGs. Arousals were counted per hour of sleep. Results We found 1) hemispheric differences in pre-ictal and ictal spectral power ( p = 0.034), during AHC hemiplegic episodes 2) 22% reduced beta power ( p = 0.017) and 26% increased delta power ( p = 0.025) during wakefulness in AHC versus controls. There were 98% more arousals in the AHC group versus controls ( p = 0.0003). Conclusions There are hemispheric differences in spectral power preceding hemiplegic episodes in adults with AHC, and sleep is disrupted. Significance Spectral EEG changes may be a potential predictive tool for AHC hemiplegic episodes. Significantly disrupted sleep is a feature of AHC.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0268720
DOI:
10.1371/journal.pone.0268720.g001
DOI:
10.1371/journal.pone.0268720.g002
DOI:
10.1371/journal.pone.0268720.t001
DOI:
10.1371/journal.pone.0268720.t002
DOI:
10.1371/journal.pone.0268720.t003
DOI:
10.1371/journal.pone.0268720.s001
DOI:
10.1371/journal.pone.0268720.s002
DOI:
10.1371/journal.pone.0268720.s003
DOI:
10.1371/journal.pone.0268720.s004
DOI:
10.1371/journal.pone.0268720.r001
DOI:
10.1371/journal.pone.0268720.r002
DOI:
10.1371/journal.pone.0268720.r003
DOI:
10.1371/journal.pone.0268720.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2267670-3
Permalink