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  • 1
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    Higgs-Yukawa model on the lattice
    EDP Sciences ; 2018
    In:  EPJ Web of Conferences Vol. 175 ( 2018), p. 08017-
    Details
    In: EPJ Web of Conferences, EDP Sciences, Vol. 175 ( 2018), p. 08017-
    Abstract: We present results from two projects on lattice calculations for the Higgs-Yukawa model. First we report progress on the search of first-order thermal phase transitions in the presence of a dimension-six operator, with the choices of bare couplings that lead to viable phenomenological predictions. In this project the simulations are performed using overlap fermions. Secondly, our study for applying finite-size scaling techniques near the Gaussian fixed point of the Higgs-Yukawa model is presented. We discuss the analytical formulae for the Higgs Yukawa model and show results for a first numerical study in the pure O (4) scalar sector of the theory.
    Type of Medium: Online Resource
    ISSN: 2100-014X
    URL: Article
    DOI: 10.1051/epjconf/201817508017
    Language: English
    Publisher: EDP Sciences
    Publication Date: 2018
    detail.hit.zdb_id: 2595425-8
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  • 2
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    Tensor Network study of the (1+1)-dimensional Thirring Model
    EDP Sciences ; 2018
    In:  EPJ Web of Conferences Vol. 175 ( 2018), p. 11017-
    Details
    In: EPJ Web of Conferences, EDP Sciences, Vol. 175 ( 2018), p. 11017-
    Abstract: Tensor Network methods have been established as a powerful technique for simulating low dimensional strongly-correlated systems for over two decades. Employing the formalism of Matrix Product States, we investigate the phase diagram of the massive Thirring model. We also show the possibility of studying soliton dynamics and topological phase transition via the Thirring model.
    Type of Medium: Online Resource
    ISSN: 2100-014X
    URL: Article
    DOI: 10.1051/epjconf/201817511017
    Language: English
    Publisher: EDP Sciences
    Publication Date: 2018
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  • 3
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    Abstract MP42: Subfractions of High-density Lipoprotein Cholesterol and Carotid Intima-media Thickness
    Ovid Technologies (Wolters Kluwer Health) ; 2016
    In:  Circulation Vol. 133, No. suppl_1 ( 2016-03)
    Details
    In: Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 133, No. suppl_1 ( 2016-03)
    Abstract: Background and Purpose: Recent drug trials have challenged the “HDL-cholesterol anti-atherosclerotic hypothesis”, suggesting that total levels of HDL-C may not be best target for intervention. HDL-cholesterol (HDL-C) subfractions may be better markers of vascular risk than total levels of HDL-C. The objective of this cross-sectional study was to investigate the relation between HDL2-C and HDL3-C fractions and carotid intima-media thickness (cIMT) in the population-based Northern Manhattan Study. Methods: We evaluated 988 stroke-free participants (mean age 66±8 years; 60% women; 66% Hispanic, and 34% Non-Hispanic) with available data on HDL-C subfractions using precipitation method and cIMT assessed by a high-resolution carotid ultrasound. The associations between HDL-C subfractions and cIMT were analyzed by multiple linear regression models. Results: The mean HDL2-C was 14 ± 8 mg/dl, HDL3-C 32 ± 8 mg/dl, and the mean total HDL-C was 46 ±14 mg/dl. The mean cIMT was 0.90 ± 0.08 mm. After controlling for demographics and vascular risk factors, HDL2-C and total HDL-C were inversely associated with cIMT (per 2SDs, beta= -0.012, p=0.03 and beta= -0.012, p=0.04, respectively). The same inverse association was more pronounced among those with diabetes (per 2SDs, HDL2-C: beta= -0.036, p=0.04; HDL-C: beta= -0.032, p=0.04). HDL3-C was inversely associated with cIMT but the association was not significant (per 2SDs, beta= -0.008, p=0.13) after adjustment. Conclusions: HDL2-C had greater effect on cIMT then HDL3-C in this urban population. This effect was especially pronounced among individuals with diabetes. More research in needed to determine anti-atherosclerotic effects of HDL-C subfractions and clinical relevance of raising their levels.
    Type of Medium: Online Resource
    ISSN: 0009-7322 , 1524-4539
    URL: Article
    DOI: 10.1161/circ.133.suppl_1.mp42
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2016
    detail.hit.zdb_id: 1466401-X
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  • 4
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    Online Resource
    Validation of “(fr)AGILE”: a quick tool to identify multidimensional frailty in the elderly
    Springer Science and Business Media LLC ; 2020
    In:  BMC Geriatrics Vol. 20, No. 1 ( 2020-12)
    Details
    In: BMC Geriatrics, Springer Science and Business Media LLC, Vol. 20, No. 1 ( 2020-12)
    Abstract: Several tools have been proposed and validated to operationally define frailty. Recently, the Italian Frailty index (IFi), an Italian modified version of Frailty index, has been validated but its use in clinical practice is limited by long time of administration. Therefore, the aim of this study was to create and validate a quick version of the IFi (AGILE). Methods Validation study was performed by administering IFi and AGILE, after a Comprehensive Geriatric Assessment (CGA) in 401 subjects aged 65 or over (77 ± 7 years). AGILE was a 10-items tool created starting from the more predictive items of the four domains of frailty investigated by IFi (mental, physical, socioeconomic and nutritional). AGILE scores were stratified in light, moderate and severe frailty. At 24 months of follow-up, death, disability (taking into account an increase in ADL lost ≥1 from the baseline) and hospitalization were considered. Area under curve (AUC) was evaluated for both IFi and AGILE. Results Administration time was 9.5 ± 3.8 min for IFi administered after a CGA, and 2.4 ± 1.2 min for AGILE, regardless of CGA ( p   〈  0.001). With increasing degree of frailty, prevalence of mortality increased progressively from 6.5 to 41.8% and from 9.0 to 33.3%, disability from 16.1 to 64.2% and from 22.1 to 59.8% and hospitalization from 17.2 to 58.7% and from 27.0 to 52.2% with AGILE and IFi, respectively ( p  = NS). Relative Risk for each unit of increase in AGILE was 56, 44 and 24% for mortality, disability and hospitalization, respectively and was lower for IFi (8, 7 and 4% for mortality, disability and hospitalization, respectively). The AUC was higher in AGILE vs. IFi for mortality (0.729 vs. 0.698), disability (0.715 vs. 0.682) and hospitalization (0.645 vs. 0.630). Conclusions Our study shows that AGILE is a rapid and effective tool for screening multidimensional frailty, able to predict mortality, disability and hospitalization, especially useful in care settings that require reliable assessment instruments with short administration time.
    Type of Medium: Online Resource
    ISSN: 1471-2318
    URL: Article
    DOI: 10.1186/s12877-020-01788-1
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 2059865-8
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  • 5
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    Short-Term Effect of Atorvastatin on Carotid Artery Elasticity : A Pilot Study
    Ovid Technologies (Wolters Kluwer Health) ; 2011
    In:  Stroke Vol. 42, No. 12 ( 2011-12), p. 3460-3464
    Details
    In: Stroke, Ovid Technologies (Wolters Kluwer Health), Vol. 42, No. 12 ( 2011-12), p. 3460-3464
    Abstract: Few studies have examined the early effects of statins on carotid artery elasticity, a potential surrogate marker of cardiovascular risk. This study examined the short-term effects of atorvastatin 80 mg daily on carotid elasticity measured by high-resolution B-mode ultrasound. Methods— The study included 40 stroke-free and statin-naive subjects older than age 45 (mean age, 70±7 years; 55% men; 64% Caribbean-Hispanic). Outcome measures included carotid stiffness indices at 14 and 30 days after initiation of treatment. The systolic and diastolic diameters of the right common carotid artery were averaged from multiple B-mode imaging frames. Absolute and relative changes of strain [(systolic diameter−diastolic diameter)/diastolic diameter], stiffness (β) [ln (systolic/diastolic blood pressure)/strain] , and distensibility (1/β adjusted for wall thickness) from baseline were compared by the repeated measures t test and were considered significant at α=0.05. Results— Baseline mean stiffness was 0.08 (95% confidence interval [CI], 0.06–0.10). It significantly decreased at day 30 to 0.05 (CI, 0.04–0.06; P 〈 0.01). Mean baseline distensibility was 15.25 (CI, 13.18–17.32), increasing significantly at day 30 to 17.23 (CI, 14.01–20.45; P 〈 0.05). An improvement in distensibility of ≥10% from baseline was observed in 29 (73%) subjects. Changes in stiffness and distensibility were maximal among subjects with baseline low-density lipoprotein levels 〈 130 mg/dL. Conclusions— Short-term treatment with high-dose atorvastatin was associated with improvement in the carotid elasticity metrics. Carotid artery elasticity measured by B-mode ultrasound is a simple noninvasive measure of arterial wall function and may be a useful surrogate end point in clinical trials targeting individuals at increased risk for atherosclerosis.
    Type of Medium: Online Resource
    ISSN: 0039-2499 , 1524-4628
    URL: Article
    DOI: 10.1161/STROKEAHA.111.625418
    RVK:
    XA 10000
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2011
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  • 6
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    Subfractions of High-Density Lipoprotein-Cholesterol and Carotid Intima-Media Thickness : The Northern Manhattan Study
    Ovid Technologies (Wolters Kluwer Health) ; 2016
    In:  Stroke Vol. 47, No. 6 ( 2016-06), p. 1508-1513
    Details
    In: Stroke, Ovid Technologies (Wolters Kluwer Health), Vol. 47, No. 6 ( 2016-06), p. 1508-1513
    Abstract: Recent drug trials have challenged the high-density lipoprotein-cholesterol (HDL-C) antiatherosclerotic hypothesis, suggesting that total level of HDL-C may not be the best target for intervention. HDL-C subfractions may be better markers of vascular risk than total levels of HDL-C. The objective of this cross-sectional study was to investigate the relationship between HDL2-C and HDL3-C fractions and carotid intima-media thickness (cIMT) in the population-based Northern Manhattan Study. Methods— We evaluated 988 stroke-free participants (mean age, 66±8 years; 60% women; 66% Hispanic, and 34% non-Hispanic) with available data on HDL-C subfractions using precipitation method and cIMT assessed by a high-resolution carotid ultrasound. The associations between HDL-C subfractions and cIMT were analyzed by multiple linear regression models. Results— The mean HDL2-C was 14±8 mg/dL, HDL3-C 32±8 mg/dL, and the mean total HDL-C was 46±14 mg/dL. The mean cIMT was 0.90±0.08 mm. After controlling for demographics and vascular risk factors, HDL2-C and total HDL-C were inversely associated with cIMT (per 2 SDs, β=−0.017, P =0.001 and β=−0.012, P =0.03, respectively). The same inverse association was more pronounced among those with diabetes mellitus (per 2SDs, HDL2-C: β=−0.043, P =0.003 and HDL-C: β=−0.029, P =0.02). HDL3-C was not associated with cIMT. Conclusions— HDL2-C had greater effect on cIMT than HDL3-C in this large urban population. The effect of HDL2-C was especially pronounced among individuals with diabetes mellitus. More research is needed to determine antiatherosclerotic effects of HDL-C subfractions and their clinical relevance.
    Type of Medium: Online Resource
    ISSN: 0039-2499 , 1524-4628
    URL: Article
    DOI: 10.1161/STROKEAHA.115.012009
    RVK:
    XA 10000
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2016
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  • 7
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    Online Resource
    Traditional Cardiovascular Risk Factors Explain the Minority of the Variability in Carotid Plaque
    Ovid Technologies (Wolters Kluwer Health) ; 2012
    In:  Stroke Vol. 43, No. 7 ( 2012-07), p. 1755-1760
    Details
    In: Stroke, Ovid Technologies (Wolters Kluwer Health), Vol. 43, No. 7 ( 2012-07), p. 1755-1760
    Abstract: Subclinical atherosclerotic plaque is an important marker of increased vascular risk. Identifying factors underlying the variability in burden of atherosclerotic carotid plaque unexplained by traditional vascular risk factors may help target novel preventive strategies. Methods— As a part of the carotid substudy of the Northern Manhattan Study (NOMAS), 1790 stroke-free individuals (mean age, 69±9; 60% women; 61% Hispanic, 19% black, 18% white) were assessed for total plaque area (TPA) burden using 2-dimensional carotid ultrasound imaging. Multiple linear regression models were constructed. Model 1 used prespecified traditional risk factors: age, sex, low-density lipoprotein cholesterol, diabetes mellitus, pack-years of smoking, blood pressure, and treatment for blood pressure; and Model 2, an addition of socioeconomic and less traditional risk factors. The contributions of the components of the Framingham heart risk score and the NOMAS Global Vascular Risk Score to the TPA were explored. Results— Prevalence of carotid plaque was 58%. Mean TPA was 13±19 mm 2 . Model 1 explained 19.5% of the variance in TPA burden ( R 2 =0.195). Model 2 explained 21.9% of TPA burden. Similarly, the Framingham heart risk score explained 18.8% and NOMAS global vascular risk score 21.5% of the TPA variance. Conclusions— The variation in preclinical carotid plaque burden is largely unexplained by traditional and less traditional vascular risk factors, suggesting that other unaccounted environmental and genetic factors play an important role in the determination of atherosclerotic plaque. Identification of these factors may lead to new approaches to prevent stroke and cardiovascular disease.
    Type of Medium: Online Resource
    ISSN: 0039-2499 , 1524-4628
    URL: Article
    DOI: 10.1161/STROKEAHA.112.651059
    RVK:
    XA 10000
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2012
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  • 8
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    Genetic Linkage of Serum Homocysteine in Dominican Families : The Family Study of Stroke Risk and Carotid Atherosclerosis
    Ovid Technologies (Wolters Kluwer Health) ; 2010
    In:  Stroke Vol. 41, No. 7 ( 2010-07), p. 1356-1362
    Details
    In: Stroke, Ovid Technologies (Wolters Kluwer Health), Vol. 41, No. 7 ( 2010-07), p. 1356-1362
    Abstract: Background and Purpose— Homocysteine levels are determined by genetic and environmental factors. Several studies have linked high plasma levels of total homocysteine to the increased risk of cardiovascular disease, stroke, and many other conditions. However, the exact mechanism of documented and novel total homocysteine quantitative trait loci to that risk is unknown. Methods— We have performed linkage analysis in 100 high-risk Dominican families with 1362 members. Probands were selected from the population-based Northern Manhattan Study. A set of 405 microsatellite markers was used to screen the whole genome. Variance components analysis was used to detect evidence for linkage after adjusting for stroke risk factors. Ordered-subset analysis based on Dominican Republic enrollment was conducted. Results— Total homocysteine levels had a heritability of 0.44 ( P 〈 0.0001). The most significant evidence for linkage was found at chromosome 17q24 (maximum logarithm of odds [MLOD]=2.66, P =0.0005) with a peak at D17S2193 and was significantly increased in a subset of families with a high proportion of Dominican Republic enrollment (MLOD=3.92, P =0.0022). Additionally, modest evidence for linkage was found at chromosome 2p21 (MLOD=1.77, P =0.0033) with a peak at D2S1356 and was significantly increased in a subset of families with a low proportion of Dominican Republic enrollment (MLOD=2.82, P =0.0097). Conclusions— We found a strong evidence for novel quantitative trait loci on chromosomes 2 and 17 for total homocysteine plasma levels in Dominican families. Our family study provides essential data for a better understanding of the genetic mechanisms associated with elevated total homocysteine levels leading to cardiovascular disease after accounting for environmental risk factors.
    Type of Medium: Online Resource
    ISSN: 0039-2499 , 1524-4628
    URL: Article
    DOI: 10.1161/STROKEAHA.109.573626
    RVK:
    XA 10000
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2010
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  • 9
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    Carotid Intima-Media Thickness Is Associated With White Matter Hyperintensities : The Northern Manhattan Study
    Ovid Technologies (Wolters Kluwer Health) ; 2018
    In:  Stroke Vol. 49, No. 2 ( 2018-02), p. 304-311
    Details
    In: Stroke, Ovid Technologies (Wolters Kluwer Health), Vol. 49, No. 2 ( 2018-02), p. 304-311
    Abstract: Brain white matter hyperintensities (WMH) have been associated with increased risk of stroke, cognitive decline, and dementia. WMH can be a manifestation of small vessel disease, although the total microvascular contribution to multifactorial WMH pathophysiology remains unknown. We hypothesized a possible relationship between carotid intima-media thickness (cIMT), an ultrasound imaging marker of subclinical vascular disease, and brain WMH in a multiethnic, elderly stroke-free community-based cohort. Methods— We evaluated the relationship between cIMT and WMH in the population-based Northern Manhattan Study, among individuals free of stroke. We used linear regression to examine the association of continuous measures of cIMT with quantitatively derived WMH volume, as a proportion of cranial volume, measured from fluid-attenuaded inversion recovery magnetic resonance imaging while adjusting for sociodemographics, lifestyle, and vascular risk factors. Results— In a cohort of 1229 participants (mean age, 71±9 years; 60% women, 15% White; 18% Black; 65% Hispanics), the mean cIMT was 0.71±0.08 mm and the median log-transformed WMH volume was 0.36 (interquartile range, 0.21–0.76). In a multivariable model, larger cIMT was significantly associated with greater WMH volume (β=0.046 per SD cIMT; P =0.04). Age and race/ethnicity were significant modifiers ( P for age, 0.02; and P for race/ethnicity, 0.04). cIMT was associated with WMH volume in participants 70 years or older (β=0.088 per SD cIMT; P =0.01) and among Hispanics (β=0.084 per SD cIMT; P =0.003). Conclusions— Larger cIMT was associated with greater burden of cerebral WM lesions independently of demographics and traditional vascular risk factors, particularly among elderly and Hispanic participants, who are at high risk for stroke and cognitive decline.
    Type of Medium: Online Resource
    ISSN: 0039-2499 , 1524-4628
    URL: Article
    DOI: 10.1161/STROKEAHA.117.018943
    RVK:
    XA 10000
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2018
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  • 10
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    The role of epsilon PKC in acute and chronic diseases: Possible pharmacological implications of its modulators
    Elsevier BV ; 2016
    In:  Pharmacological Research Vol. 111 ( 2016-09), p. 659-667
    Details
    In: Pharmacological Research, Elsevier BV, Vol. 111 ( 2016-09), p. 659-667
    Type of Medium: Online Resource
    ISSN: 1043-6618
    URL: Article
    DOI: 10.1016/j.phrs.2016.07.029
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2016
    detail.hit.zdb_id: 1471456-5
    SSG: 15,3
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