In:
Digestive Surgery, S. Karger AG, Vol. 35, No. 4 ( 2018), p. 333-341
Abstract:
〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 The aim of this study was to evaluate the results of major hepatectomies for metastasis in elderly colorectal cancer patients, for whom limited data exist in the literature. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 From January 2006 to January 2013, 3,034 patients underwent hepatectomy for colorectal liver metastasis in 32 French surgical centers. Repeat hepatectomies were excluded from the study. Based on a 1: 4 propensity score matching model, 42 patients aged ≥80 (OG) were matched with 168 patients & #x3c;80 years (YG) in order to obtain 2 well-balanced and homogeneous groups with regards to therapy and prognostic factors. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 The unmatched cohort consisted of 744 patients (OG: 〈 i 〉 n 〈 /i 〉 = 42; YG: 〈 i 〉 n 〈 /i 〉 = 702). After PS matching, there was no difference in terms of general morbidity, rates of Dindo-Clavien score ≥III (OG: 16% vs. YG: 21%, 〈 i 〉 p 〈 /i 〉 = 0.663), surgical morbidity (OG: 16% vs. YG: 21%, 〈 i 〉 p 〈 /i 〉 = 0.663), reoperation (OG:10% vs. YG: 5%, 〈 i 〉 p 〈 /i 〉 = 0.263), 90-day mortality (OG: 0% vs. YG:2%, 〈 i 〉 p 〈 /i 〉 = 1), and total median hospital stay (OG: 12 vs. YG: 12, 〈 i 〉 p 〈 /i 〉 = 0.972). Both groups experienced similar 3- and 5-year overall survival (82 and 82% OG vs.78 and 67% YG) and disease-free survival (40 and 35% OG vs. 45 and 35% YG at 3 and 5 years). 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 No difference in perioperative and postoperative outcomes and disease-free and overall survival was found. Major hepatectomy in selected octogenarian patients is safe and feasible.
Type of Medium:
Online Resource
ISSN:
0253-4886
,
1421-9883
Language:
English
Publisher:
S. Karger AG
Publication Date:
2018
detail.hit.zdb_id:
1468560-7
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