In:
International Journal of Cancer, Wiley, Vol. 139, No. 9 ( 2016-11), p. 2068-2081
Abstract:
What's new? Mesenchymal stem cells (MSCs) within a tumor can suppress the immune response against that tumor. In this study, the authors discovered a pathway by which MSCs can block antigen‐presenting cells (APCs) from stimulating cytotoxic T cells. This pathway inhibits an enzyme involved in the production of cysteine. Surprisingly, this cysteine deficiency doesn't suppress activation of the T cells, only their proliferation. These results suggest that targeting gene expression in MSCs may provide a useful therapeutic strategy to enhance the ability of T cells to eradicate tumors.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2016
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
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