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  • 1
    Online Resource
    Online Resource
    FORMULATION AND EVALUATION OF SOLID DISPERSION OF TADALAFIL
    Society of Pharmaceutical Tecnocrats ; 2018
    In:  International Journal of Drug Regulatory Affairs Vol. 6, No. 1 ( 2018-03-15), p. 26-34
    Details
    In: International Journal of Drug Regulatory Affairs, Society of Pharmaceutical Tecnocrats, Vol. 6, No. 1 ( 2018-03-15), p. 26-34
    Abstract: Tadalafil is used for the treatment of the erectile dysfunction (ED) and pulmonary arterial hypertension. It is having low aqueous solubility thus it shows poor bioavailability of about 28% by after oral administration. To improve its solubility and dissolution profile solid dispersions (SDPs) of Tadalafil was prepared by physical mixing and solvent evaporation method using polyvinyl pyrollidone-K30 (PVP-30) as a hydrophilic polymeric carrier in different proportions with respect to drug (drug to polymer ratio 1:1 to 1:5). Drug and polymer compatibility studies were performed using FTIR study. The best suitable ratio and method was selected on the basis of enhanced aqueous solubility of drugs. Further selected SDPs were evaluated for various parameters like DSC analysis, percentage yield, percent drug content, saturation solubility, percent drug dissolution and stability studies. FTIR study indicated no incompatibility between Tadalafil and PVP-K30. SDPs prepared with drug to polymer ratio 1:3 and solvent evaporation method was found to be best as they shown significant increased (up to 10 fold) in aqueous solubility in comparison with that of others. DSC study also suggested the depression in the crystalline nature of Tadalafil. Selected SDPs exhibited good stability up to 3 months at 25 ± 2°C /60 ± 5% RH. Based on the results it can be concluded that, SDPs shown remarkable increase in the aqueous solubility and dissolution of Tadalafil and it may improve oral bioavailability of drug as compared with plain drug.
    Type of Medium: Online Resource
    ISSN: 2321-6794 , 2321-7162
    URL: Article
    DOI: 10.22270/ijdra.v6i1.224
    Language: Unknown
    Publisher: Society of Pharmaceutical Tecnocrats
    Publication Date: 2018
    detail.hit.zdb_id: 2738279-5
    SSG: 15,3
    Location Call Number Limitation Availability
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    Online Resource
  • 2
    Online Resource
    Online Resource
    Dorzolamide suppresses PKCδ -TIRAP-p38 MAPK signaling axis to dampen the inflammatory response
    Future Science Ltd ; 2023
    In:  Future Medicinal Chemistry Vol. 15, No. 6 ( 2023-03), p. 533-554
    Details
    In: Future Medicinal Chemistry, Future Science Ltd, Vol. 15, No. 6 ( 2023-03), p. 533-554
    Abstract: Background: Sepsis is a syndrome due to microbial infection causing impaired multiorgan function. Its underlying cause is immune dysfunction and macrophages play an essential role. Methods: TIRAP interaction with PKCδ in macrophage was studied, revealing downstream signaling by Western blot and quantitative reverse transcriptase PCR. Dorzolamide (DZD) disrupting TIRAP–PKCδ interaction was identified by virtual screening and validated in vitro and in septic mice. Results: The study highlights the indispensable role of TIRAP–PKCδ in p38 MAPK-activation, NF-κB- and AP-1-mediated proinflammatory cytokines expression, whereas DZD significantly attenuated the signaling. Conclusion: Targeting TIRAP–PKCδ interaction by DZD is a novel therapeutic approach for treating sepsis.
    Type of Medium: Online Resource
    ISSN: 1756-8919 , 1756-8927
    URL: Article
    DOI: 10.4155/fmc-2022-0260
    Language: English
    Publisher: Future Science Ltd
    Publication Date: 2023
    SSG: 15,3
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  • 3
    Online Resource
    Online Resource
    Characteristics, Biological Activities, Synthesis, and Methods for the Determination of Brexpiprazole in Different Matrices
    Bentham Science Publishers Ltd. ; 2022
    In:  Current Pharmaceutical Analysis Vol. 18, No. 8 ( 2022-10), p. 765-776
    Details
    In: Current Pharmaceutical Analysis, Bentham Science Publishers Ltd., Vol. 18, No. 8 ( 2022-10), p. 765-776
    Abstract: Brexpiprazole (BRZ) is a "third-generation" antipsychotic dopaminergic (D2) and 5HT1A (serotonin) partial agonist, approved in July 2015 by the US Food and Drug Administration for the treatment of the major depressive disorder (MDD) other than schizophrenia in adults. Antipsychotics are known to produce extrapyramidal effects as side effects. The recent development in this segment is of piperazine-based antipsychotic BRZ, which is more specific towards indented indications (depression) and has fewer side effects. Objective: To critically review the different analytical methods available in the literature. Methods: Eight spectrophotometry-based studies, nineteen chromatography-based studies, and two other method-based studies were found in the literature search. A brief discussion on pharmacokinetics and the mechanism of action is also included. Conclutions: This review can be used for the development of more robust and suitable analytical methods for the determination of drugs in different matrices. A brief discussion concerning the approach towards the advancement of green analytical methods is likewise one of the points of this review.
    Type of Medium: Online Resource
    ISSN: 1573-4129
    URL: Article
    DOI: 10.2174/1573412918666220406123600
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2022
    SSG: 15,3
    Location Call Number Limitation Availability
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    Online Resource
  • 4
    Online Resource
    Online Resource
    AN OVERVIEW ABOUT NOVEL FAST DISSOLVING ORAL FILMS
    Society of Pharmaceutical Tecnocrats ; 2018
    In:  International Journal of Drug Regulatory Affairs Vol. 6, No. 1 ( 2018-03-15), p. 1-7
    Details
    In: International Journal of Drug Regulatory Affairs, Society of Pharmaceutical Tecnocrats, Vol. 6, No. 1 ( 2018-03-15), p. 1-7
    Abstract: Nowadays, novel fast dissolving oral films (FDF) have come in existence as an alternative dosage form in comparison with tablet, capsules, syrup and other oral dosage forms with respect to patient convenience and compliance. Fast dissolving oral films are helpful to paediatric and geriatric patients who experience difficulties in swallowing traditional oral solid-dosage forms. The FDF drug delivery systems are solid dosage form which disintegrate or dissolve within seconds when placed in the mouth cavity without need of water or chewing. FDF provide better drug dissolution, faster onset of action, bypassing the first pass metabolism of drugs and thus enhance their oral bioavailability with reduced dosing frequency. These formulations are suitable for cough, cold, sore throat, allergenic conditions, nausea, pain, hypertension and CNS disorders. The present review provides the details about the recent advancement in design and development of oral fast dissolving film.
    Type of Medium: Online Resource
    ISSN: 2321-6794 , 2321-7162
    URL: Article
    DOI: 10.22270/journal.v6i1.220
    Language: Unknown
    Publisher: Society of Pharmaceutical Tecnocrats
    Publication Date: 2018
    detail.hit.zdb_id: 2738279-5
    SSG: 15,3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    FORMULATION AND EVALUATION OF SOLID DISPERSION OF TADALAFIL
    Society of Pharmaceutical Tecnocrats ; 2018
    In:  International Journal of Drug Regulatory Affairs Vol. 6, No. 1 ( 2018-03-15), p. 26-34
    Details
    In: International Journal of Drug Regulatory Affairs, Society of Pharmaceutical Tecnocrats, Vol. 6, No. 1 ( 2018-03-15), p. 26-34
    Abstract: Tadalafil is used for the treatment of the erectile dysfunction (ED) and pulmonary arterial hypertension. It is having low aqueous solubility thus it shows poor bioavailability of about 28% by after oral administration. To improve its solubility and dissolution profile solid dispersions (SDPs) of Tadalafil was prepared by physical mixing and solvent evaporation method using polyvinyl pyrollidone-K30 (PVP-30) as a hydrophilic polymeric carrier in different proportions with respect to drug (drug to polymer ratio 1:1 to 1:5). Drug and polymer compatibility studies were performed using FTIR study. The best suitable ratio and method was selected on the basis of enhanced aqueous solubility of drugs. Further selected SDPs were evaluated for various parameters like DSC analysis, percentage yield, percent drug content, saturation solubility, percent drug dissolution and stability studies. FTIR study indicated no incompatibility between Tadalafil and PVP-K30. SDPs prepared with drug to polymer ratio 1:3 and solvent evaporation method was found to be best as they shown significant increased (up to 10 fold) in aqueous solubility in comparison with that of others. DSC study also suggested the depression in the crystalline nature of Tadalafil. Selected SDPs exhibited good stability up to 3 months at 25 ± 2°C /60 ± 5% RH. Based on the results it can be concluded that, SDPs shown remarkable increase in the aqueous solubility and dissolution of Tadalafil and it may improve oral bioavailability of drug as compared with plain drug.
    Type of Medium: Online Resource
    ISSN: 2321-6794 , 2321-7162
    URL: Article
    DOI: 10.22270/journal.v6i1.224
    Language: Unknown
    Publisher: Society of Pharmaceutical Tecnocrats
    Publication Date: 2018
    detail.hit.zdb_id: 2738279-5
    SSG: 15,3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 6
    Online Resource
    Online Resource
    AN OVERVIEW ABOUT NOVEL FAST DISSOLVING ORAL FILMS
    Society of Pharmaceutical Tecnocrats ; 2018
    In:  International Journal of Drug Regulatory Affairs Vol. 6, No. 1 ( 2018-03-15), p. 1-7
    Details
    In: International Journal of Drug Regulatory Affairs, Society of Pharmaceutical Tecnocrats, Vol. 6, No. 1 ( 2018-03-15), p. 1-7
    Abstract: Nowadays, novel fast dissolving oral films (FDF) have come in existence as an alternative dosage form in comparison with tablet, capsules, syrup and other oral dosage forms with respect to patient convenience and compliance. Fast dissolving oral films are helpful to paediatric and geriatric patients who experience difficulties in swallowing traditional oral solid-dosage forms. The FDF drug delivery systems are solid dosage form which disintegrate or dissolve within seconds when placed in the mouth cavity without need of water or chewing. FDF provide better drug dissolution, faster onset of action, bypassing the first pass metabolism of drugs and thus enhance their oral bioavailability with reduced dosing frequency. These formulations are suitable for cough, cold, sore throat, allergenic conditions, nausea, pain, hypertension and CNS disorders. The present review provides the details about the recent advancement in design and development of oral fast dissolving film.
    Type of Medium: Online Resource
    ISSN: 2321-6794 , 2321-7162
    URL: Article
    DOI: 10.22270/ijdra.v6i1.220
    Language: Unknown
    Publisher: Society of Pharmaceutical Tecnocrats
    Publication Date: 2018
    detail.hit.zdb_id: 2738279-5
    SSG: 15,3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 7
    Online Resource
    Online Resource
    Repurposing Thioridazine (TDZ) as an anti-inflammatory agent
    Springer Science and Business Media LLC ; 2018
    In:  Scientific Reports Vol. 8, No. 1 ( 2018-08-20)
    Details
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 8, No. 1 ( 2018-08-20)
    Abstract: Nuclear factor-kB (NF-kB) is a crucial transcription factor in the signal transduction cascade of the inflammatory signaling. Activation of NF-κB depends on the phosphorylation of IκBα by IκB kinase (IKKβ) followed by subsequent ubiquitination and degradation. This leads to the nuclear translocation of the p50- p65 subunits of NF-κB, and further triggers pro-inflammatory cytokine gene expression. Thus, in the need of a more effective therapy for the treatment of inflammatory diseases, specific inhibition of IKKβ represents a rational alternative strategy to the current therapies. A computer-aided drug identification protocol was followed to identify novel IKKβ inhibitors from a database of over 1500 Food and Drug Administration (FDA) drugs. The best scoring compounds were compared with the already known high-potency IKKβ inhibitors for their ability to bind and inhibit IKKβ by evaluating their docking energy. Finally, Thioridazinehydrochloride (TDZ), a potent antipsychotic drug against Schizophrenia was selected and its efficiency in inhibiting IκBα protein degradation and NF-κB activation was experimentally validated. Our study has demonstrated that TDZ blocks IκBα protein degradation and subsequent NF-κB activation to inhibit inflammation. Thus, it is a potential repurposed drug against inflammation.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    URL: Article
    DOI: 10.1038/s41598-018-30763-5
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2018
    detail.hit.zdb_id: 2615211-3
    Location Call Number Limitation Availability
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    Online Resource
  • 8
    Online Resource
    Online Resource
    FORMULATION AND EVALUATION OF POLYHERBAL HAIR OIL FOR GENERAL PURPOSE
    Indian Drug Manufacturers' Association (IDMA) ; 2022
    In:  Indian Drugs Vol. 59, No. 12 ( 2022-12-27), p. 82-84
    Details
    In: Indian Drugs, Indian Drug Manufacturers' Association (IDMA), Vol. 59, No. 12 ( 2022-12-27), p. 82-84
    Abstract: The present era is witnessing a renaissance of herbal products due to the credence of having no or minimal adverse effects allied with them. The present lifestyle (stress, anxiety, lack of nutritious diet, lethargy, unusual sleep pattern etc.) as well as pollution triggers the hair loss not only in later age but also in younger ones. Keeping this problem and advantage of herbal products in cognizance, a herbal hair oil containing various herbs (Emblica officinalis, Allium cepa, Murraya koenigii, Azadirachta indica, Eclipta prostrata, Bacopa monera) for general purpose has been formulated and evaluated. Among all the prepared formulations, the formulation F3 was found best in terms of pH, viscosity, specific gravity, acid value, saponification value and refractive index with optimum values in all cases.
    Type of Medium: Online Resource
    ISSN: 0019-462X
    URL: Article
    DOI: 10.53879/id.59.12.13402
    Language: Unknown
    Publisher: Indian Drug Manufacturers' Association (IDMA)
    Publication Date: 2022
    SSG: 15,3
    Location Call Number Limitation Availability
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    Online Resource
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