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  • 1
    In: Cancer Control, SAGE Publications, Vol. 27, No. 1 ( 2020-01-01), p. 107327482096888-
    Abstract: Tumor budding (Bd) has been demonstrated to be a promising prognostic factor in many carcinomas and in gastric cancer. It may represent an optimal additional parameter that is helpful for risk stratification in gastric adenocarcinoma. Hence, the present research was designed to predict the survival outcomes of gastric cancer in Vietnam, applying the tumor budding criteria of the International Tumor Budding Consensus Conference (ITBCC) 2016. Methods: The present study was conducted on 109 gastric cancer patients who underwent surgery but did not receive neo-adjuvant chemotherapy from 2012 to 2015. The patients’ clinicopathological features were recorded. Bd was evaluated according to the 2016 ITBCC criteria and classified as Bd1 (0–4 buds), Bd2 (5–9 buds), and Bd3 (≥10 buds) grades, in addition to being categorized into 2 main Bd groups: low ( 〈 10 buds) and high (≥10 buds) Bd. Kaplan–Meier and log-rank models were applied to analyze survival proportions. Results: Of all the patients, 22.9% were classified as Bd1, 31.2% as Bd2, and 45.9% as Bd3 grades. Furthermore, 54.1% patients were categorized into the low and 45.9% into the high Bd groups. Patients with Bd1 and Bd2 grades (the low Bd group) exhibited the best prognosis, with 5-year overall survival (OS) rates of 85.7%, 90.8%, and90.3%, respectively. Patients with Bd3 grade (the high Bd group exhibited the worst prognosis, and none of them lived for 5 years (p 〈 0.001). Similar to OS rates, disease-free survival (DFS) rates markedly reduced from the Bd1 to Bd3 grade: Bd1, 95.0%; Bd2, 84.7%; and Bd3, 0% (p 〈 0.001). Conclusion: Patients with different gastric cancer Bd grades exhibited significantly different OS and DFS rates. The present study findings suggest that the ITBCC criteria can be used to stratify Bd for the treatment and prognosis of gastric cancer patients in Vietnam.
    Type of Medium: Online Resource
    ISSN: 1073-2748 , 1073-2748
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2004182-2
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  • 2
    In: OALib, Scientific Research Publishing, Inc., Vol. 10, No. 03 ( 2023), p. 1-11
    Type of Medium: Online Resource
    ISSN: 2333-9721 , 2333-9705
    Language: Unknown
    Publisher: Scientific Research Publishing, Inc.
    Publication Date: 2023
    detail.hit.zdb_id: 2777820-4
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  • 3
    In: Cancer Control, SAGE Publications, Vol. 29 ( 2022-01), p. 107327482211402-
    Abstract: Though menstrual and reproductive factors have been associated with the risk of breast cancer in many populations, very few studies have been conducted among Vietnamese women. This study aimed to assess the association between menstrual and reproductive factors and the risk of breast cancer in Vietnamese women. Methods A retrospective case-control study of 490 breast cancer cases and 468 controls was conducted in Northern Vietnam. Unconditional logistic regression models adjusting for confounders were used to estimate odds ratios (ORs) and their 95% confidence intervals (CIs) for the associations of menstrual and reproductive factors with the risk of breast cancer; overall and by cancer subtype. Results Among breast cancer patients, the luminal B subtype was the most frequent (48.6%), followed by HER2-overexpressing (24.5%), luminal A (16.7%), and triple-negative breast cancer (TNBC; 10.2%). Among menopausal women, menopausal age at 50 years or older (OR = 1.71, 95% CI: 1.15-2.57 vs. 〈 50 y) was associated with an increased risk of breast cancer. Earlier age at menarche ( 〈 13 y) was associated with a significantly increased risk of breast cancer (OR = 2.66, 95% CI: 1.08-7.51) among premenopausal women only and the luminal A subtype of breast cancer (OR = 3.06, 95% CI: 1.04-8.16). Having more than two children was associated with a reduced risk of premenopausal (OR = .42, 95%CI: .21-.83), luminal B (OR = .43, 95% CI: .24-.79), and TNBC (OR = .34, 95% CI: .14-.89). Later menopause was positively associated with the risk of breast cancer with HER2 overexpression (OR = 2.19, 95% CI: 1.14-4.23). Conclusion Associations of menstrual and reproductive factors with breast cancer among Vietnamese women, particularly for among premenopausal women and for the luminal A subtype, are generally consistent with those reported from other countries. These findings suggest that changes in menstrual and reproductive patterns among young Vietnamese women may contribute to the recent rising incidence of breast cancer in Vietnam.
    Type of Medium: Online Resource
    ISSN: 1073-2748 , 1526-2359
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2004182-2
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  • 4
    Online Resource
    Online Resource
    American Association for Cancer Research (AACR) ; 2019
    In:  Cancer Research Vol. 79, No. 13_Supplement ( 2019-07-01), p. 1618-1618
    In: Cancer Research, American Association for Cancer Research (AACR), Vol. 79, No. 13_Supplement ( 2019-07-01), p. 1618-1618
    Abstract: Background: From 1980 to 2010, new breast cancer cases increased by more than 50% worldwide. Disease burden increased even more rapidly in low- and middle-income countries (LMICs), where over half of breast cancer cases now occur. In Vietnam, approximately 15229 new cases of breast cancer were diagnosed with 6103 resulted deaths in 2018. Breast cancer can be detected early by screening; however, it is not covered by medical insurance. Mammogram is currently one of the most reliable screening tools for breast cancer. Regular mammograms can help detect breast cancer early, thus allowing for early treatment Purposes: To raise public awareness on breast cancer prevention and early detection, while promoting a habitual routine of breast self - examination and breast cancer screening participation; to call on companies to include breast cancer screening on the periodic health examination for female employees. Methods: We collected data on risk factors of breast cancer. Breast Imaging-Reporting and Data System (BI-RADS fifth edition) scores from the radiology reports were utilized. The information collected from women who completed the questionnaires included: age, BMI, family history of breast cancer, personal history of breast or ovarian cancer, number of pregnancies, number of babies born, number of abortion, number of miscarriage, stillbirth, hormonal medication use (hormone replacement therapy and daily oral contraceptive), age of menarche, menopause, smoking habit, and breast self-examination results. Results: There were 10,000 Vietnamese women who were over 40 years old (over 35 years old if their mother or their sister had breast cancer) participated in this program. Rate for regular breast self-examination was 19.1%. In the 40 to 55 years-old age group, the rate was 70%, 2.2% for women aged 35-39 years (with a family history of breast cancer). Eight women were diagnosed with breast cancer, the incidence rate was 80 per 100,000 population, respectively. Conclusions: The total fee for a breast cancer screening in Viet Nam is approximately $25 ($20 for a mammogram and $5 for consultation fee). This remains one of the best solutions to detect breast cancer early and reduce the overall burden of cancer treatment costs on the already strained Vietnamese health system. Note: This abstract was not presented at the meeting. Citation Format: Voc Tai Dang, Tu Van Dao, Thuan Van Tran, Huong Thi Tran. Breast cancer screening in low and lower - middle income country : A program in Vietnam [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1618.
    Type of Medium: Online Resource
    ISSN: 0008-5472 , 1538-7445
    RVK:
    RVK:
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2019
    detail.hit.zdb_id: 2036785-5
    detail.hit.zdb_id: 1432-1
    detail.hit.zdb_id: 410466-3
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  • 5
    In: Journal of Clinical Oncology, American Society of Clinical Oncology (ASCO), Vol. 41, No. 16_suppl ( 2023-06-01), p. 8531-8531
    Abstract: 8531 Background: The prevalence of EGFR mutations ( EGFRm) in resected stage I-III NSCLC remains controversial as prior research studies were retrospective in nature. EARLY-EGFR is the first prospective, international study to determine the prevalence of EGFRm and treatment patterns in patients (pts) with early-stage NSCLC. Methods: EARLY-EGFR (NCT04742192), a non-interventional real-world study, captured data on EGFRm status, treatment patterns, demographic, clinical and pathological characteristics in consecutively enrolled pts with surgically resected stage IA-IIIB (AJCC 8 th ) non-squamous NSCLC (Mar 2021 – Oct 2022). The primary endpoint was prevalence of EGFRm and secondary endpoints included prevalence of EGFRm subtypes and treatment patterns. Results: Of 601 pts (median [range] age: 62 [30-86] yrs) enrolled at 33 centers across Middle East and Africa (n=16), Latin America (n=80), and Asia (n=505), 317 (52.7%) were females, 354 (58.9%) were never smokers. The majority had stage IA-IB NSCLC (64.1%) involving right lung (62.9%), no nodal involvement (81.5%), T1a-T2b tumor (82.7%), adenocarcinoma histology (98.7%), and 105/420 (25.0%) tumors were poorly differentiated. About 23.3% (130/559) were diagnosed through a screening program; 60/539 (11.1%) reported family history of lung cancer. The overall prevalence of EGFRm was 50.7% (300/592). Exon-19 deletions accounted for 50.3%, L858R mutations for 35.7%, and compound mutations for 2.3% of mutations. EGFRm tumors were found to be PD-L1 positive in 38.5% of cases (15/39). Women had higher EGFRm rate than men (63.6% vs 36.2%). Compared with EGFR wild type (wt), pts with EGFRm were more likely to be never smokers (39.5% vs 60.5%) and have stage I/II NSCLC (46.5% vs 53.5%) (Table). Of 216 stage II/III NSCLC pts, only 51.4% received systemic adjuvant therapy. Significantly higher EGFRm rates in stages I and II than in stage III NSCLC (p 〈 0.001 and p=0.050) were found, while no significant difference was found between stages I and II NSCLC (p=0.158). Conclusions: In this first prospective, real-world study of EGFRm prevalence in resected NSCLC, stage III and smoking were independent predictors associated with decreased odds of EGFRm. The results highlight the need to adhere to ASCO adjuvant chemotherapy guidelines, as only half of stage II/III NSCLC pts received adjuvant systemic therapy. Clinical trial information: NCT04742192 . [Table: see text]
    Type of Medium: Online Resource
    ISSN: 0732-183X , 1527-7755
    RVK:
    RVK:
    Language: English
    Publisher: American Society of Clinical Oncology (ASCO)
    Publication Date: 2023
    detail.hit.zdb_id: 2005181-5
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  • 6
    In: Future Oncology, Future Medicine Ltd
    Abstract: This is a summary of results from a phase 3 clinical study called HIMALAYA. HIMALAYA looked at treatment with one dose of a medication called tremelimumab combined with multiple doses of a medication called durvalumab (the STRIDE regimen) or multiple doses of durvalumab alone. These treatments were compared with a medication called sorafenib in participants with unresectable hepatocellular carcinoma (HCC). HCC is a type of liver cancer that is difficult to treat because it is often diagnosed when it is unresectable, meaning it can no longer be removed with surgery. Sorafenib has been the main treatment for unresectable HCC since 2007. However, people who take sorafenib may experience side effects that can reduce their quality of life, so alternative medicines are being trialed. Tremelimumab and durvalumab are types of drugs called immunotherapies, and they both work in different ways to help the body's immune system fight cancer. What were the results of the study? Participants who took STRIDE lived longer than participants who took sorafenib, whilst participants who took durvalumab alone lived a similar length of time as participants who took sorafenib. Participants who took STRIDE or durvalumab had a lower relative risk of experiencing worsening in their quality of life than participants who took sorafenib. The side effects that participants who received STRIDE or durvalumab experienced were expected for these types of treatments and could mostly be managed. What do the results of the study mean? Overall, STRIDE is more effective than sorafenib for people with unresectable HCC. Clinical Trial Registration: NCT03298451 (HIMALAYA) ( ClinicalTrials.gov )
    Type of Medium: Online Resource
    ISSN: 1479-6694 , 1744-8301
    Language: English
    Publisher: Future Medicine Ltd
    Publication Date: 2023
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  • 7
    Online Resource
    Online Resource
    Ho Chi Minh City Open University ; 2018
    In:  HO CHI MINH CITY OPEN UNIVERSITY JOURNAL OF SCIENCE - SOCIAL SCIENCES Vol. 8, No. 1 ( 2018-12-07), p. 48-67
    In: HO CHI MINH CITY OPEN UNIVERSITY JOURNAL OF SCIENCE - SOCIAL SCIENCES, Ho Chi Minh City Open University, Vol. 8, No. 1 ( 2018-12-07), p. 48-67
    Abstract: Thanks to the implementation of Vietnam’s economic renovation or ‘Doi Moi’ policy since 1986, Ho Chi Minh City (HCMC) urban has grown quickly. However, this also leads to an increase in inequality. Its peri-urban area, which undergoes higher level of urbanization than urban area, faces more problems such as land use change, inadequate development process, unequal allocation of services and investment, and ignorance of environmental protection and cultural preservation. These impacts show inequality in standards of living between residents of the two areas. Using the framework of the Peri-Urban Political-Ecology, this paper aims to depict a general picture of the situation and analyse the causes of social inequalities between these two areas in terms of economy, public services, and environment through “everyday practices” (i.e. events, problems, stories, etc.). The paper uses HCMC’s statistical data in 2015-2017 periods and research findings from previous studies. The results shows that the main causes in inequalities between these two areas are the inevitability of urban metabolism and the unequal power interaction among the state, society and market.
    Type of Medium: Online Resource
    ISSN: 2734-9624 , 2734-9357
    Language: Unknown
    Publisher: Ho Chi Minh City Open University
    Publication Date: 2018
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  • 8
    Online Resource
    Online Resource
    Institute of Electrical and Electronics Engineers (IEEE) ; 2017
    In:  IEEE Transactions on Smart Grid Vol. 8, No. 3 ( 2017-5), p. 1252-1263
    In: IEEE Transactions on Smart Grid, Institute of Electrical and Electronics Engineers (IEEE), Vol. 8, No. 3 ( 2017-5), p. 1252-1263
    Type of Medium: Online Resource
    ISSN: 1949-3053 , 1949-3061
    Language: Unknown
    Publisher: Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017
    detail.hit.zdb_id: 2560004-7
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  • 9
    In: Tạp chí Y học Cộng đồng, Institute of Community Health, Vol. 63, No. 1 ( 2022-01-06)
    Abstract: Nghiên cứu này được tiến hành nhằm đánh giá hiệu quả can thiệp sử dụng tin nhắn di động cải thiện kiến thức, thái độ và thực hành của cha mẹ trong chăm sóc sức khỏe răng miệng cho trẻ 3 tuổi tại một số trường mầm non công lập tỉnh Hà Nam. Thiết kế nghiên cứu thử nghiệm so sánh trước-sau có nhóm chứng được thực hiện trên 430 cha mẹ của trẻ 3 tuổi tại 4 trường mầm non ở thành phố Phủ Lý, tỉnh Hà Nam. Cách tiếp cận đánh giá khác biệt trong khác biệt (difference in difference) được áp dụng. Kết quả cho thấy, so với nhóm chứng, can thiệp có thể làm tăng 3,57 lần khả năng cha mẹ có kiến thức đạt ở thời điểm 6 tháng, tăng 3,46 lần khả năng cha mẹ có thái độ đạt ở thời điểm 6 tháng sau can thiệp và tăng 2,84 lần khả năng cha mẹ có thực hành đạt ở thời điểm 12 tháng sau can thiệp. Các kết quả này cho thấy tính khả thi và chấp nhận của việc triển khai các can thiệp này tới người dân để phòng chống sâu răng sớm ở trẻ.
    Type of Medium: Online Resource
    ISSN: 2354-0613
    URL: Issue
    Language: Unknown
    Publisher: Institute of Community Health
    Publication Date: 2022
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  • 10
    In: Tạp chí Y học Dự phòng, Tap chi Y hoc du phong (Vietnam Journal of Preventive Medicine-VJPM), Vol. 32, No. 2 ( 2022-04-26), p. 59-66
    Abstract: Nghiên cứu này được thực hiện nhằm mô tả kiến thức, thái độ, thực hành trong dự phòng sâu răng chotrẻ của cha/mẹ trẻ 3 tuổi học tại một số trường mầm non công lập tại thành phố Phủ Lý, tỉnh Hà Nam năm2020, và xác định một số yếu tố liên quan. Nghiên cứu mô tả cắt ngang tại bốn trường mầm non công lậptrên 430 cha/mẹ của trẻ, sử dụng bộ câu hỏi cấu trúc để phỏng vấn kiến thức - thái độ - thực hành. Kếtquả nghiên cứu cho thấy, tỷ lệ kiến thức đúng cao nhất về tuổi đánh răng (77,2%) và nguyên nhân gây sâu răng (73,8%). Tỷ lệ cha/mẹ có thái độ đúng về vai trò của chăm sóc răng miệng là 38,6%. Nhìn chung, có 47,6% cha/mẹ có kiến thức đạt, 19,1% có thái độ tích cực và 31,3% có thực hành đạt. Cần thiết có các can thiệp hỗ trợ cha/mẹ và người chăm sóc trẻ để gia tăng kiến thức thái độ và thực hành.
    Type of Medium: Online Resource
    ISSN: 0868-2836
    Language: Unknown
    Publisher: Tap chi Y hoc du phong (Vietnam Journal of Preventive Medicine-VJPM)
    Publication Date: 2022
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