In:
PLOS Computational Biology, Public Library of Science (PLoS), Vol. 18, No. 1 ( 2022-1-10), p. e1009749-
Kurzfassung:
We have used a variety of theoretical and experimental techniques to study the role of four basic amino acids–Arginine, Lysine, Ornithine and L-2,4-Diaminobutyric acid–on the structure, flexibility and sequence-dependent stability of DNA. We found that the presence of organic ions stabilizes the duplexes and significantly reduces the difference in stability between AT- and GC-rich duplexes with respect to the control conditions. This suggests that these amino acids, ingredients of the primordial soup during abiogenesis, could have helped to equalize the stability of AT- and GC-rich DNA oligomers, facilitating a general non-catalysed self-replication of DNA. Experiments and simulations demonstrate that organic ions have an effect that goes beyond the general electrostatic screening, involving specific interactions along the grooves of the double helix. We conclude that organic ions, largely ignored in the DNA world, should be reconsidered as crucial structural elements far from mimics of small inorganic cations.
Materialart:
Online-Ressource
ISSN:
1553-7358
DOI:
10.1371/journal.pcbi.1009749
DOI:
10.1371/journal.pcbi.1009749.g001
DOI:
10.1371/journal.pcbi.1009749.g002
DOI:
10.1371/journal.pcbi.1009749.g003
DOI:
10.1371/journal.pcbi.1009749.g004
DOI:
10.1371/journal.pcbi.1009749.g005
DOI:
10.1371/journal.pcbi.1009749.g006
DOI:
10.1371/journal.pcbi.1009749.g007
DOI:
10.1371/journal.pcbi.1009749.g008
DOI:
10.1371/journal.pcbi.1009749.s001
DOI:
10.1371/journal.pcbi.1009749.s002
DOI:
10.1371/journal.pcbi.1009749.s003
DOI:
10.1371/journal.pcbi.1009749.s004
DOI:
10.1371/journal.pcbi.1009749.s005
DOI:
10.1371/journal.pcbi.1009749.s006
DOI:
10.1371/journal.pcbi.1009749.s007
DOI:
10.1371/journal.pcbi.1009749.s008
DOI:
10.1371/journal.pcbi.1009749.s009
DOI:
10.1371/journal.pcbi.1009749.s010
DOI:
10.1371/journal.pcbi.1009749.s011
DOI:
10.1371/journal.pcbi.1009749.s012
DOI:
10.1371/journal.pcbi.1009749.s013
DOI:
10.1371/journal.pcbi.1009749.s014
DOI:
10.1371/journal.pcbi.1009749.s015
DOI:
10.1371/journal.pcbi.1009749.s016
DOI:
10.1371/journal.pcbi.1009749.s017
Sprache:
Englisch
Verlag:
Public Library of Science (PLoS)
Publikationsdatum:
2022
ZDB Id:
2193340-6
Permalink