In:
Chemistry & Biodiversity, Wiley, Vol. 19, No. 8 ( 2022-08)
Abstract:
A convenient three‐component synthetic approach was developed en route to new and significative N ‐arylated‐dihydrobenzo[ g ]quinoline‐5,10‐diones using 2‐hydroxy‐1,4‐naphthoquinone, a variety of aromatic aldehydes, and 4‐(arylamino)furan‐2(5 H )‐ones. A sequence of steps including Knoevenagel condensation, Michael addition, [1,3]‐hydrogen shift, intramolecular cyclization and dehydration led to the formation of products. All the products were structurally characterized by spectroscopic techniques and assessed in terms of their cytotoxicity profile against four cancer cell lines (KB, HepG2, A549, and MCF7), and human embryonic kidney (Hek‐293) cell lines.
Type of Medium:
Online Resource
ISSN:
1612-1872
,
1612-1880
DOI:
10.1002/cbdv.202200359
Language:
English
Publisher:
Wiley
Publication Date:
2022
detail.hit.zdb_id:
2139001-0
SSG:
12
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