In:
Endocrine-Related Cancer, Bioscientifica, Vol. 19, No. 1 ( 2011-12-22), p. 95-99
Abstract:
An increased association between neuroendocrine tumors of the gastrointestinal tract and pancreas (GEP-NET) and other second primary malignancies has been suggested. We determined whether there is indeed an increased risk for second primary malignancies in GEP-NET patients compared with an age- and sex-matched control group of patients with identical malignancies. The series comprised 243 men and 216 women, diagnosed with a GEP-NET between 2000 and 2009 in a tertiary referral center. The timeline, before-at-after diagnosis, and the type of other malignancies were studied using person-year methodology. Poisson distributions were used for testing statistical significance. All data were cross-checked with the Dutch National Cancer Registry. Out of 459 patients with GEP-NET, 67 (13.7%) had a second primary cancer diagnosis: 25 previous cancers (5.4%), 13 synchronous cancers (2.8%), and 29 metachronous cancers (6.3%). The most common types of second primary cancer were breast cancer ( n =10), colorectal cancer ( n =8), melanoma ( n =6), and prostate cancer ( n =5). The number of patients with a cancer history was lower than expected, although not significant ( n =25 vs n =34.5). The diagnosis of synchronous cancers, mainly colorectal tumors, was higher than expected ( n =13 vs n =6.1, P 〈 0.05). Metachronous tumors occurred as frequent as expected ( n =29 vs n =25.2, NS). In conclusion, our results are in contrast to previous studies and demonstrate that only the occurrence of synchronous second primary malignancies, mainly colorectal cancers, is increased in GEP-NET patients compared with the general population.
Type of Medium:
Online Resource
ISSN:
1351-0088
,
1479-6821
Language:
Unknown
Publisher:
Bioscientifica
Publication Date:
2011
detail.hit.zdb_id:
2010895-3
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