In:
PLOS Pathogens, Public Library of Science (PLoS), Vol. 17, No. 3 ( 2021-3-18), p. e1009397-
Abstract:
Peste des petits ruminants (PPR) is a deadly viral disease that mainly affects small domestic ruminants. This disease threaten global food security and rural economy but its control is complicated notably because of extensive, poorly monitored animal movements in infected regions. Here we combined the largest PPR virus genetic and animal mobility network data ever collected in a single region to improve our understanding of PPR endemic transmission dynamics in West African countries. Phylogenetic analyses identified the presence of multiple PPRV genetic clades that may be considered as part of different transmission networks evolving in parallel in West Africa. A strong correlation was found between virus genetic distance and network-related distances. Viruses sampled within the same mobility communities are significantly more likely to belong to the same genetic clade. These results provide evidence for the importance of animal mobility in PPR transmission in the region. Some nodes of the network were associated with PPRV sequences belonging to different clades, representing potential “hotspots” for PPR circulation. Our results suggest that combining genetic and mobility network data could help identifying sites that are key for virus entrance and spread in specific areas. Such information could enhance our capacity to develop locally adapted control and surveillance strategies, using among other risk factors, information on animal mobility.
Type of Medium:
Online Resource
ISSN:
1553-7374
DOI:
10.1371/journal.ppat.1009397
DOI:
10.1371/journal.ppat.1009397.g001
DOI:
10.1371/journal.ppat.1009397.g002
DOI:
10.1371/journal.ppat.1009397.g003
DOI:
10.1371/journal.ppat.1009397.g004
DOI:
10.1371/journal.ppat.1009397.g005
DOI:
10.1371/journal.ppat.1009397.g006
DOI:
10.1371/journal.ppat.1009397.g007
DOI:
10.1371/journal.ppat.1009397.t001
DOI:
10.1371/journal.ppat.1009397.s001
DOI:
10.1371/journal.ppat.1009397.s002
DOI:
10.1371/journal.ppat.1009397.s003
DOI:
10.1371/journal.ppat.1009397.s004
DOI:
10.1371/journal.ppat.1009397.s005
DOI:
10.1371/journal.ppat.1009397.s006
DOI:
10.1371/journal.ppat.1009397.s007
DOI:
10.1371/journal.ppat.1009397.s008
DOI:
10.1371/journal.ppat.1009397.s009
DOI:
10.1371/journal.ppat.1009397.s010
DOI:
10.1371/journal.ppat.1009397.s011
DOI:
10.1371/journal.ppat.1009397.s012
DOI:
10.1371/journal.ppat.1009397.s013
DOI:
10.1371/journal.ppat.1009397.s014
DOI:
10.1371/journal.ppat.1009397.s015
DOI:
10.1371/journal.ppat.1009397.s016
DOI:
10.1371/journal.ppat.1009397.s017
DOI:
10.1371/journal.ppat.1009397.s018
DOI:
10.1371/journal.ppat.1009397.s019
DOI:
10.1371/journal.ppat.1009397.s020
DOI:
10.1371/journal.ppat.1009397.s021
DOI:
10.1371/journal.ppat.1009397.s022
DOI:
10.1371/journal.ppat.1009397.s023
DOI:
10.1371/journal.ppat.1009397.s024
DOI:
10.1371/journal.ppat.1009397.r001
DOI:
10.1371/journal.ppat.1009397.r002
DOI:
10.1371/journal.ppat.1009397.r003
DOI:
10.1371/journal.ppat.1009397.r004
DOI:
10.1371/journal.ppat.1009397.r005
DOI:
10.1371/journal.ppat.1009397.r006
DOI:
10.1371/journal.ppat.1009397.r007
DOI:
10.1371/journal.ppat.1009397.r008
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2205412-1
Permalink