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  • 1
    Online Resource
    Online Resource
    Impact of Evidence‐Based Stroke Care on Patient Outcomes: A Multilevel Analysis of an International Study
    Ovid Technologies (Wolters Kluwer Health) ; 2019
    In:  Journal of the American Heart Association Vol. 8, No. 13 ( 2019-07-02)
    Details
    In: Journal of the American Heart Association, Ovid Technologies (Wolters Kluwer Health), Vol. 8, No. 13 ( 2019-07-02)
    Abstract: The uptake of proven stroke treatments varies widely. We aimed to determine the association of evidence‐based processes of care for acute ischemic stroke ( AIS ) and clinical outcome of patients who participated in the HEADPOST (Head Positioning in Acute Stroke Trial), a multicenter cluster crossover trial of lying flat versus sitting up, head positioning in acute stroke. Methods and Results Use of 8 AIS processes of care were considered: reperfusion therapy in eligible patients; acute stroke unit care; antihypertensive, antiplatelet, statin, and anticoagulation for atrial fibrillation; dysphagia assessment; and physiotherapist review. Hierarchical, mixed, logistic regression models were performed to determine associations with good outcome (modified Rankin Scale scores 0–2) at 90 days, adjusted for patient and hospital variables. Among 9485 patients with AIS, implementation of all processes of care in eligible patients, or “defect‐free” care, was associated with improved outcome (odds ratio, 1.40; 95% CI, 1.18–1.65) and better survival (odds ratio, 2.23; 95% CI , 1.62–3.09). Defect‐free stroke care was also significantly associated with excellent outcome (modified Rankin Scale score 0–1) (odds ratio, 1.22; 95% CI , 1.04–1.43). No hospital characteristic was independently predictive of outcome. Only 1445 (15%) of eligible patients with AIS received all processes of care, with significant regional variations in overall and individual rates. Conclusions Use of evidence‐based care is associated with improved clinical outcome in AIS . Strategies are required to address regional variation in the use of proven AIS treatments. Clinical Trial Registration URL : https://www.clinicaltrials.gov . Unique Identifier: NCT 02162017.
    Type of Medium: Online Resource
    ISSN: 2047-9980
    URL: Article
    DOI: 10.1161/JAHA.119.012640
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2019
    detail.hit.zdb_id: 2653953-6
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  • 2
    Online Resource
    Online Resource
    Development of an Assistant System of Clean Intermittent Catheterization for Neurogenic Bladder Dysfunction Patients
    MDPI AG ; 2019
    In:  Applied Sciences Vol. 9, No. 7 ( 2019-04-05), p. 1433-
    Details
    In: Applied Sciences, MDPI AG, Vol. 9, No. 7 ( 2019-04-05), p. 1433-
    Abstract: Clean intermittent catheterization (CIC) is one of the methods currently used to prevent overdistention of the bladder in patients with neurogenic bladder dysfunction (NBD). It is also helpful in preventing urinary tract infection and retaining the function of the bladder. Voiding diary and social behavior are necessary for the patients to maintain their physical and mental health, nevertheless there are currently no good assistant systems to help them achieve these goals. In this study, we propose a CIC assistant system with the functions of recording and tracking the voided volume and accessible lavatory. The aim of this study is to assess the effects from the 12 patients who joined the proposed system. Information collected from participants included their demographics, past medicals, injury characteristics, current and past bladder managements, and any NBD related complications. The results indicate that most patients felt relieved that they could know the voided volume and track their history easily. Moreover, the accessible lavatory function of the proposed system could reduce time consumption by 43.1% in finding the suitable lavatory, thus the desire and willingness of patients to travel increased from 25% to 75% after using the system. The proposed system could help doctors with clinical diagnoses, and help patients to understand more about the history of their catheterization volume and time period. This study provided essential information and design for future investigation.
    Type of Medium: Online Resource
    ISSN: 2076-3417
    URL: Article
    DOI: 10.3390/app9071433
    Language: English
    Publisher: MDPI AG
    Publication Date: 2019
    detail.hit.zdb_id: 2704225-X
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  • 3
    Online Resource
    Online Resource
    THE EFFECT OF LABORATORY-DEVELOPED VIDEO GAMES ON BALANCE PERFORMANCE IN CHILDREN WITH DEVELOPMENTAL COORDINATION DISORDER
    National Taiwan University ; 2018
    In:  Biomedical Engineering: Applications, Basis and Communications Vol. 30, No. 01 ( 2018-02), p. 1850005-
    Details
    In: Biomedical Engineering: Applications, Basis and Communications, National Taiwan University, Vol. 30, No. 01 ( 2018-02), p. 1850005-
    Abstract: Developmental coordination disorder (DCD) refers to the motor skill difficulty without any explainable medical conditions. The prevalence rate of DCD is estimated to be 5–12% in Taiwan. Balance deficit is one of the main characteristics of children with DCD. The aim of this study was to examine the effect of a self-developed balance training program on the balance performance in children with DCD. Twenty four children aged 5–10 years old with DCD and 12 age-matched typically developing (TD) children participated in the study. Children with DCD were randomly divided between an experimental group (DCD-exp) who received treatment with the iBalance training program and the control group (DCD-con) who did not received treatment. TD children also did not receive treatment as a comparison group. All the children were tested with the movement assessment battery for children-2nd edition (MABC-2) and iBalance assessment system before and after the intervention period. A significant improvement of the MABC-2 balance component score, time duration of one-leg standing and the number of success trials with dynamic balance tasks were noted in the children of DCD-exp but not in the children of DCD-con and TD. The results suggest that the iBalance training program is effective for a short time treatment effect for children with DCD. The long term effect and transfer effect need to be examined.
    Type of Medium: Online Resource
    ISSN: 1016-2372 , 1793-7132
    URL: Article
    DOI: 10.4015/S1016237218500059
    Language: English
    Publisher: National Taiwan University
    Publication Date: 2018
    detail.hit.zdb_id: 1444455-0
    detail.hit.zdb_id: 2390680-7
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  • 4
    Online Resource
    Online Resource
    The Cost-Effectiveness Analysis of Transplant-Ineligible Myeloma Patients with Bortezomib plus Thalidomide plus Dexamethasone (VTD) or Bortezomib plus Melphalan plus Prednisolone (VMP) Treatment in Southern Taiwan
    MDPI AG ; 2022
    In:  Journal of Personalized Medicine Vol. 12, No. 2 ( 2022-01-19), p. 130-
    Details
    In: Journal of Personalized Medicine, MDPI AG, Vol. 12, No. 2 ( 2022-01-19), p. 130-
    Abstract: Background: This study aimed to evaluate the cost-effectiveness of treating transplant-ineligible myeloma patients with either a bortezomib plus thalidomide plus dexamethasone (VTD) or a bortezomib plus melphalan plus prednisolone (VMP) treatment in Taiwan. Methods: Newly diagnosed, transplant-ineligible myeloma patients with VTD or VMP therapy were enrolled from two medical centers in southern Taiwan. Quality-adjusted life years (QALYs) were used as the measurement unit of the effectiveness evaluation, and the incremental cost-effectiveness ratio (ICER) was used for comparison between the two groups. A net monetary benefit approach and cost-effectiveness acceptability curve were also used for the cost-effectiveness assessment. A one-way sensitivity analysis was used to check the impact of different parameters. In total, 77 patients were enrolled in the study with 43 patients in the VTD group and 34 patients in the VMP group. Clinical presentations were similar without significant difference, except the VTD group had a higher survival rate (p = 0.029). Comparisons of the two groups over an eight-month time horizon revealed a significant lower mean of direct medical costs in the VTD group than in the VMP group (p 〈 0.001), and a significantly higher average QALY was gained (p 〈 0.001). Conclusions: The study demonstrated the greater clinical benefit and cost-effectiveness of VTD compared to VMP therapy in transplant-ineligible, newly diagnosed myeloma patients.
    Type of Medium: Online Resource
    ISSN: 2075-4426
    URL: Article
    DOI: 10.3390/jpm12020130
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2662248-8
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  • 5
    Online Resource
    Online Resource
    A Scoping Review of The Efficacy of Virtual Reality and Exergaming on Patients of Musculoskeletal System Disorder
    MDPI AG ; 2019
    In:  Journal of Clinical Medicine Vol. 8, No. 6 ( 2019-06-04), p. 791-
    Details
    In: Journal of Clinical Medicine, MDPI AG, Vol. 8, No. 6 ( 2019-06-04), p. 791-
    Abstract: To assess the effects of virtual reality on patients with musculoskeletal disorders by means of a scoping review of randomized controlled trials (RCTs). The databases included PubMed, IEEE, and the MEDLINE database. Articles involving RCTs with higher than five points on the Physiotherapy Evidence Database (PEDro) scale were reviewed for suitability and inclusion. The methodological quality of the included RCT was evaluated using the PEDro scale. The three reviewers extracted relevant information from the included studies. Fourteen RCT articles were included. When compared with simple usual care or other forms of treatment, there was significant pain relief, increased functional capacity, reduced symptoms of the disorder, and increased joint angles for the virtual reality treatment of chronic musculoskeletal disorders. Furthermore, burn patients with acute pain were able to experience a significant therapeutic effect on pain relief. However, virtual reality treatment of patients with non-chronic pain such as total knee replacement, ankle sprains, as well as those who went through very short virtual reality treatments, did not show a significant difference in parameters, as compared with simple usual care and other forms of treatment. Current evidence supports VR treatment as having a significant effect on pain relief, increased joint mobility, or motor function of patients with chronic musculoskeletal disorders. VR seems quite effective in relieving the pain of patients with acute burns as well.
    Type of Medium: Online Resource
    ISSN: 2077-0383
    URL: Article
    DOI: 10.3390/jcm8060791
    Language: English
    Publisher: MDPI AG
    Publication Date: 2019
    detail.hit.zdb_id: 2662592-1
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  • 6
    Online Resource
    Online Resource
    Development of a Bipolar Pulse Generator for High-Frequency Ultrasound Imaging System
    Trans Tech Publications, Ltd. ; 2013
    In:  Applied Mechanics and Materials Vol. 311 ( 2013-2), p. 217-221
    Details
    In: Applied Mechanics and Materials, Trans Tech Publications, Ltd., Vol. 311 ( 2013-2), p. 217-221
    Abstract: The pulse generator is the critical component in high-frequency ultrasound imaging systems. Currently, there still exist some shortcomings about commercial ultrasound image systems and devices such as 5900 PR …etc.. However, to achieve a higher sensitivity and high performance, a programmable pulser generator is desired to match the requirements of high frequency ultrasound image system. In this study, we utilized a novel bipolar pulse generator method to overcome those issues in developed high resolution image system. As the needs of application in clinic, a real –time of high-frequency ultrasound imaging systems, including pulse generator, high speed scanning mechanism, high voltage protection and FPGA trigger control circuit, was developed in our Laboratory. This paper will focus to compare the performance of the bipolar generator and unipolar generator as used in pulse generator device respectively. Finally, the developed bipolar pulse generator show the better performance than the unipolar generator does. The bipolar system can generate clean N-cycle bipolar pulses and improve the center frequency of transducer up to 60 MHz. The axial resolution of scan system has been improved to around 60 μm. In addition, the result indicated that the proposed bipolar pulser could increase 4 dB for pulse/echo waveforms amplitude.
    Type of Medium: Online Resource
    ISSN: 1662-7482
    URL: Issue
    URL: Article
    DOI: 10.4028/www.scientific.net/AMM.311
    DOI: 10.4028/www.scientific.net/AMM.311.217
    Language: Unknown
    Publisher: Trans Tech Publications, Ltd.
    Publication Date: 2013
    detail.hit.zdb_id: 2251882-4
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  • 7
    Online Resource
    Online Resource
    A real-time rule-based method of stenosis evaluation for arteriovenous fistula care by multiple sites blood flow measurement
    Springer Science and Business Media LLC ; 2021
    In:  Microsystem Technologies Vol. 27, No. 4 ( 2021-04), p. 1283-1293
    Details
    In: Microsystem Technologies, Springer Science and Business Media LLC, Vol. 27, No. 4 ( 2021-04), p. 1283-1293
    Type of Medium: Online Resource
    ISSN: 0946-7076 , 1432-1858
    URL: Article
    DOI: 10.1007/s00542-018-4214-6
    RVK:
    ZG 1100
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 1476561-5
    detail.hit.zdb_id: 1223008-X
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  • 8
    Online Resource
    Online Resource
    Development of a Wireless Mesh Sensing System with High-Sensitivity LiNbO3 Vibration Sensors for Robotic Arm Monitoring
    MDPI AG ; 2019
    In:  Sensors Vol. 19, No. 3 ( 2019-01-26), p. 507-
    Details
    In: Sensors, MDPI AG, Vol. 19, No. 3 ( 2019-01-26), p. 507-
    Abstract: In recent years, multi-axis robots are indispensable in automated factories due to the rapid development of Industry 4.0. Many related processes were required to have the increasing demand for accuracy, reproducibility, and abnormal detection. The monitoring function and immediate feedback for correction is more and more important. This present study integrated a highly sensitive lithium niobate (LiNbO3) vibration sensor as a sensor node (SN) and architecture of wireless mesh network (WMN) to develop a monitoring system (MS) for the robotic arm. The advantages of the thin-film LiNbO3 piezoelectric sensor were low-cost, high-sensitivity and good electrical compatibility. The experimental results obtained from the vibration platform show that the sensitivity achieved 50 mV/g and the reaction time within 1 ms. The results of on-site testing indicated that the SN could be configured on the relevant equipment quickly and detect the abnormal vibration in specific equipment effectively. Each SN could be used more than 10 h at the 80 Hz transmission rate under WMN architecture and the loss rate of transmission was less than 0.01% within 20 m.
    Type of Medium: Online Resource
    ISSN: 1424-8220
    URL: Article
    DOI: 10.3390/s19030507
    Language: English
    Publisher: MDPI AG
    Publication Date: 2019
    detail.hit.zdb_id: 2052857-7
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  • 9
    Online Resource
    Online Resource
    Virtual-reality simulator system for double interventional cardiac catheterization using haptic force producer with visual feedback
    Elsevier BV ; 2016
    In:  Computers & Electrical Engineering Vol. 53 ( 2016-07), p. 230-243
    Details
    In: Computers & Electrical Engineering, Elsevier BV, Vol. 53 ( 2016-07), p. 230-243
    Type of Medium: Online Resource
    ISSN: 0045-7906
    URL: Article
    DOI: 10.1016/j.compeleceng.2015.11.013
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2016
    detail.hit.zdb_id: 186937-1
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  • 10
    Online Resource
    Online Resource
    PRMT1-mediated FLT3 arginine methylation promotes maintenance of FLT3-ITD+ acute myeloid leukemia
    American Society of Hematology ; 2019
    In:  Blood Vol. 134, No. 6 ( 2019-08-08), p. 548-560
    Details
    In: Blood, American Society of Hematology, Vol. 134, No. 6 ( 2019-08-08), p. 548-560
    Abstract: The presence of FMS-like receptor tyrosine kinase-3 internal tandem duplication (FLT3-ITD) mutations in patients with acute myeloid leukemia (AML) is associated with poor clinical outcome. FLT3 tyrosine kinase inhibitors (TKIs), although effective in kinase ablation, do not eliminate primitive FLT3-ITD+ leukemia cells, which are potential sources of relapse. Thus, understanding the mechanisms underlying FLT3-ITD+ AML cell persistence is essential to devise future AML therapies. Here, we show that expression of protein arginine methyltransferase 1 (PRMT1), the primary type I arginine methyltransferase, is increased significantly in AML cells relative to normal hematopoietic cells. Genome-wide analysis, coimmunoprecipitation assay, and PRMT1-knockout mouse studies indicate that PRMT1 preferentially cooperates with FLT3-ITD, contributing to AML maintenance. Genetic or pharmacological inhibition of PRMT1 markedly blocked FLT3-ITD+ AML cell maintenance. Mechanistically, PRMT1 catalyzed FLT3-ITD protein methylation at arginine 972/973, and PRMT1 promoted leukemia cell growth in an FLT3 methylation–dependent manner. Moreover, the effects of FLT3-ITD methylation in AML cells were partially due to cross talk with FLT3-ITD phosphorylation at tyrosine 969. Importantly, FLT3 methylation persisted in FLT3-ITD+ AML cells following kinase inhibition, indicating that methylation occurs independently of kinase activity. Finally, in patient-derived xenograft and murine AML models, combined administration of AC220 with a type I PRMT inhibitor (MS023) enhanced elimination of FLT3-ITD+ AML cells relative to AC220 treatment alone. Our study demonstrates that PRMT1-mediated FLT3 methylation promotes AML maintenance and suggests that combining PRMT1 inhibition with FLT3 TKI treatment could be a promising approach to eliminate FLT3-ITD+ AML cells.
    Type of Medium: Online Resource
    ISSN: 0006-4971 , 1528-0020
    URL: Article
    DOI: 10.1182/blood.2019001282
    RVK:
    XA 33000
    RVK:
    XA 10000
    Language: English
    Publisher: American Society of Hematology
    Publication Date: 2019
    detail.hit.zdb_id: 1468538-3
    detail.hit.zdb_id: 80069-7
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