In:
British Journal of Haematology, Wiley, Vol. 171, No. 1 ( 2015-10), p. 130-136
Abstract:
High mobility group box ‐1 ( HMGB 1) represents a common causal agent for various types of diseases, including infective pathologies. This study aimed to investigate the role of HMGB 1 in β‐thalassemia major ( TM ) by evaluating its diagnostic and prognostic role. Fifty‐one TM patients and 30 healthy subjects ( HS ) were enrolled. Receiver operating characteristics ( ROC ) analysis was employed to calculate the area under the curve ( AUC ) for HMGB 1 to determine the best cut‐off values capable of identifying infectious episodes. Adjusted risk estimates for infective events were calculated using univariate followed by multivariate Cox proportional hazard regression analysis. Serum HMGB 1 levels were higher in TM patients than in HS (14·6 ± 8·7 vs. 2·08 ± 0·9 ng/ml, P 〈 0·0001). Patients who underwent splenectomy were characterized by lower levels of HMGB 1, when compared with patients with an intact spleen (10·2 ± 8 vs. 19·1 ± 7 ng/ml, P = 0·004). ROC analyses revealed an AUC for serum HMGB 1 of 0·801, with a sensitivity and specificity of 92·3% and 68·2% to detect an infectious episode. Low HMGB 1 levels predicted high risk of infective events ( HR : 0·81; P = 0·006). HMGB 1 represents a prognostic marker for TM patients and a predictive factor for infectious events.
Type of Medium:
Online Resource
ISSN:
0007-1048
,
1365-2141
DOI:
10.1111/bjh.2015.171.issue-1
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
1475751-5
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