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  • 1
    Online Resource
    Online Resource
    6G Network AI Architecture for Everyone-Centric Customized Services
    Institute of Electrical and Electronics Engineers (IEEE) ; 2022
    In:  IEEE Network
    Details
    In: IEEE Network, Institute of Electrical and Electronics Engineers (IEEE)
    Type of Medium: Online Resource
    ISSN: 0890-8044 , 1558-156X
    URL: Article
    DOI: 10.1109/MNET.124.2200241
    Language: Unknown
    Publisher: Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2022
    detail.hit.zdb_id: 2051708-7
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  • 2
    Online Resource
    Online Resource
    A Novel Potassium Salt Regulated Solvation Chemistry Enabling Excellent Li‐Anode Protection in Carbonate Electrolytes
    Wiley ; 2023
    In:  Advanced Materials Vol. 35, No. 25 ( 2023-06)
    Details
    In: Advanced Materials, Wiley, Vol. 35, No. 25 ( 2023-06)
    Abstract: In lithium‐metal batteries (LMBs), the compatibility of Li anode and conventional lithium hexafluorophosphate‐(LiPF 6 ) carbonate electrolyte is poor owing to the severe parasitic reactions. Herein, to resolve this issue, a delicately designed additive of potassium perfluoropinacolatoborate (KFPB) is unprecedentedly synthesized. On the one hand, KFPB additive can regulate the solvation structure of the carbonate electrolyte, promoting the formation of Li + FPB − and K + PF 6 − ion pairs with lower lowest unoccupied molecular orbital (LUMO) energy levels. On the other hand, FPB − anion possesses strong adsorption ability on Li anode. Thus, anions can preferentially adsorb and decompose on the Li‐anode surface to form a conductive and robust solid‐electrolyte interphase (SEI) layer. Only with a trace amount of KFPB additive (0.03  m ) in the carbonate electrolyte, Li dendrites’ growth can be totally suppressed, and Li||Cu and Li||Li half cells exhibit excellent Li‐plating/stripping stability upon cycling. Encouragingly, KFPB‐assisted carbonate electrolyte enables high areal capacity LiCoO 2 ||Li, LiNi 0.8 Co 0.1 Mn 0.1 O 2 (NCM811)||Li, and LiNi 0.8 Co 0.05 Al 0.15 O 2 (NCA)||Li LMBs with superior cycling stability, showing its excellent universality. This work reveals the importance of designing novel additives to regulate the solvation structure of carbonate electrolytes in improving its interface compatibility with the Li anode.
    Type of Medium: Online Resource
    ISSN: 0935-9648 , 1521-4095
    URL: Issue
    URL: Article
    DOI: 10.1002/adma.v35.25
    DOI: 10.1002/adma.202301312
    RVK:
    UA 1538
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 1474949-X
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  • 3
    Online Resource
    Online Resource
    In situ -polymerized lithium salt as a polymer electrolyte for high-safety lithium metal batteries
    Royal Society of Chemistry (RSC) ; 2023
    In:  Energy & Environmental Science Vol. 16, No. 6 ( 2023), p. 2591-2602
    Details
    In: Energy & Environmental Science, Royal Society of Chemistry (RSC), Vol. 16, No. 6 ( 2023), p. 2591-2602
    Abstract: Polymer electrolytes offer advantages of leak-proofing, excellent flexibility, and high compatibility with lithium metal, enabling the highly safe operation of lithium metal batteries (LMBs). However, most current polymer electrolytes do not meet the requirements for the practical applications of LMBs. Herein, to resolve this issue, employing thermal-induced in situ polymerization of lithium perfluoropinacolatoaluminate (LiFPA), we present a novel interface-compatible and safe single-ion conductive 3D polymer electrolyte (3D-SIPE-LiFPA). It is demonstrated that 3D-SIPE-LiFPA with a unique polyanion structure promoted the formation of a protective electrode/electrolyte interface and inhibited the dissolution–migration–deposition of transition metals (TMs). 3D-SIPE-LiFPA endowed LiNi 0.8 Co 0.1 Mn 0.1 O 2 (NCM811, 3.7 mA h cm −2 )/Li (50 μm) LMBs with a long cycle life at both the coin-cell level (80.8% after 236 cycles) and pouch-cell level (437 W h kg −1 , 95.4% after 60 cycles, injected electrolyte 2 g A h −1 ). More importantly, pouch-type NCM811/Li LMBs using 3D-SIPE-LiFPA delivered significantly enhanced onset temperature for heat release ( T onset ) and thermal runaway temperature ( T tr ) by 34 °C and 72 °C, respectively. Our strategy of polymerizing lithium salt as a polymer electrolyte opens up a new frontier to simultaneously enhance the cycle life and safety of LMBs.
    Type of Medium: Online Resource
    ISSN: 1754-5692 , 1754-5706
    URL: Article
    DOI: 10.1039/D3EE00558E
    Language: English
    Publisher: Royal Society of Chemistry (RSC)
    Publication Date: 2023
    detail.hit.zdb_id: 2439879-2
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  • 4
    Online Resource
    Online Resource
    A novel phage carrying capsule depolymerase effectively relieves pneumonia caused by multidrug-resistant Klebsiella aerogenes
    Springer Science and Business Media LLC ; 2023
    In:  Journal of Biomedical Science Vol. 30, No. 1 ( 2023-08-31)
    Details
    In: Journal of Biomedical Science, Springer Science and Business Media LLC, Vol. 30, No. 1 ( 2023-08-31)
    Abstract: Klebsiella aerogenes can cause ventilator-associated pneumonia by forming biofilms, and it is frequently associated with multidrug resistance. Phages are good antibiotic alternatives with unique advantages. There has been a lack of phage therapeutic explorations, kinetic studies, and interaction mechanism research targeting K. aerogenes . Methods Plaque assay, transmission electron microscopy and whole-genome sequencing were used to determine the biology, morphology, and genomic characteristics of the phage. A mouse pneumonia model was constructed by intratracheal/endobronchial delivery of K. aerogenes to assess the therapeutic effect of phage in vivo. Bioinformatics analysis and a prokaryotic protein expression system were used to predict and identify a novel capsule depolymerase. Confocal laser scanning microscopy, Galleria mellonella larvae infection models and other experiments were performed to clarify the function of the capsule depolymerase. Results A novel lytic phage (pK4-26) was isolated from hospital sewage. It was typical of the Podoviridae family and exhibited serotype specificity, high lytic activity, and high environmental adaptability. The whole genome is 40,234 bp in length and contains 49 coding domain sequences. Genomic data show that the phage does not carry antibiotic resistance, virulence, or lysogenic genes. The phage effectively lysed K. aerogenes in vivo, reducing mortality and alleviating pneumonia without promoting obvious side effects. A novel phage-derived depolymerase was predicted and proven to be able to digest the capsule, remove biofilms, reduce bacterial virulence, and sensitize the bacteria to serum killing. Conclusions The phage pK4-26 is a good antibiotic alternative and can effectively relieve pneumonia caused by multidrug-resistant K. aerogenes . It carries a depolymerase that removes biofilms, reduces virulence, and improves intrinsic immune sensitivity.
    Type of Medium: Online Resource
    ISSN: 1423-0127
    URL: Article
    DOI: 10.1186/s12929-023-00946-y
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 1482918-6
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  • 5
    Online Resource
    Online Resource
    Table_1.DOCX
    Frontiers Media SA ; 2023
    In:  Frontiers in Microbiology Vol. 14 ( 2023-6-22)
    Details
    In: Frontiers in Microbiology, Frontiers Media SA, Vol. 14 ( 2023-6-22)
    Abstract: Mycoplasma pneumoniae is a common causative pathogen of community-acquired pneumonia. An accurate and sensitive detection method is important for evaluating disease severity and treatment efficacy. Digital droplet PCR (ddPCR) is a competent method enabling the absolute quantification of DNA copy number with high precision and sensitivity. We established ddPCR for M. pneumoniae detection, using clinical specimens for validation, and this showed excellent specificity for M. pneumoniae . The limit of detection of ddPCR was 2.9 copies/reaction, while that for real-time PCR was 10.8 copies/reaction. In total, 178 clinical samples were used to evaluate the ddPCR assay, which correctly identified and differentiated 80 positive samples, whereas the real-time PCR tested 79 samples as positive. One sample that tested negative in real-time PCR was positive in ddPCR, with a bacterial load of three copies/test. For samples that tested positive in both methods, the cycle threshold of real-time PCR was highly correlated with the copy number of ddPCR. Bacterial loads in patients with severe M. pneumoniae pneumonia were significantly higher than those in patients with general M. pneumoniae pneumonia. The ddPCR showed that bacterial loads were significantly decreased after macrolide treatment, which could have reflected the treatment efficacy. The proposed ddPCR assay was sensitive and specific for the detection of M. pneumoniae . Quantitative monitoring of bacterial load in clinical samples could help clinicians to evaluate treatment efficacy.
    Type of Medium: Online Resource
    ISSN: 1664-302X
    URL: Article
    URL: Article
    DOI: 10.3389/fmicb.2023.1177273
    DOI: 10.3389/fmicb.2023.1177273.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2587354-4
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  • 6
    Online Resource
    Online Resource
    Glucose Induces Resistance to Polymyxins in High-Alcohol-Producing Klebsiella pneumoniae via Increasing Capsular Polysaccharide and Maintaining Intracellular ATP
    American Society for Microbiology ; 2023
    In:  Microbiology Spectrum Vol. 11, No. 4 ( 2023-08-17)
    Details
    In: Microbiology Spectrum, American Society for Microbiology, Vol. 11, No. 4 ( 2023-08-17)
    Abstract: High-alcohol-producing K. pneumoniae (HiAlc Kpn ) causes nonalcoholic fatty liver disease (NAFLD) by producing excess endogenous alcohol in the gut of patients with NAFLD, using glucose as the main carbon source. The role of glucose in the response of HiAlc Kpn to environmental stresses such as antibiotics remains unclear. In this study, we found that glucose could enhance the resistance of HiAlc Kpn to polymyxins. First, glucose inhibited the expression of crp in HiAlc Kpn and promoted the increase of capsular polysaccharide (CPS), which promoted the drug resistance of HiAlc Kpn . Second, glucose maintained high ATP levels in HiAlc Kpn cells under the pressure of polymyxins, enhancing the resistance of the cells to the killing effect of antibiotics. Notably, the inhibition of CPS formation and the decrease of intracellular ATP levels could both effectively reverse glucose-induced polymyxins resistance. Our work demonstrated the mechanism by which glucose induces polymyxins resistance in HiAlc Kpn , thereby laying the foundation for developing effective treatments for NAFLD caused by HiAlc Kpn . IMPORTANCE HiAlc Kpn can use glucose to produce excess endogenous alcohol for promoting the development of NAFLD. Polymyxins are the last line of antibiotics and are commonly used to treat infections caused by carbapenem-resistant K. pneumoniae . In this study, we found that glucose increased bacterial resistance to polymyxins via increasing CPS and maintaining intracellular ATP; this increases the risk of failure to treat NAFLD caused by multidrug-resistant HiAlc Kpn infection. Further research revealed the important roles of glucose and the global regulator, CRP, in bacterial resistance and found that inhibiting CPS formation and decreasing intracellular ATP levels could effectively reverse glucose-induced polymyxins resistance. Our work reveals that glucose and the regulatory factor CRP can affect the resistance of bacteria to polymyxins, laying a foundation for the treatment of infections caused by multidrug-resistant bacteria.
    Type of Medium: Online Resource
    ISSN: 2165-0497
    URL: Article
    DOI: 10.1128/spectrum.00031-23
    Language: English
    Publisher: American Society for Microbiology
    Publication Date: 2023
    detail.hit.zdb_id: 2807133-5
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  • 7
    Online Resource
    Online Resource
    Interphase Regulation by Multifunctional Additive Empowering High Energy Lithium‐Ion Batteries with Enhanced Cycle Life and Thermal Safety
    Wiley ; 2024
    In:  Angewandte Chemie Vol. 136, No. 5 ( 2024-01-25)
    Details
    In: Angewandte Chemie, Wiley, Vol. 136, No. 5 ( 2024-01-25)
    Abstract: High energy density lithium‐ion batteries (LIBs) adopting high‐nickel layered oxide cathodes and silicon‐based composite anodes always suffer from unsatisfied cycle life and poor safety performance, especially at elevated temperatures. Electrode /electrolyte interphase regulation by functional additives is one of the most economic and efficacious strategies to overcome this shortcoming. Herein, cyano‐groups (−CN) are introduced into lithium fluorinated phosphate to synthesize a novel multifunctional additive of lithium tetrafluoro (1,2‐dihydroxyethane‐1,1,2,2‐tetracarbonitrile) phosphate (LiTFTCP), which endows high nickel LiNi 0.8 Co 0.1 Mn 0.1 O 2 /SiO x ‐graphite composite full cell with an ultrahigh cycle life and superior safety characteristics, by adding only 0.5 wt % LiTFTCP into a LiPF 6 ‐carbonate baseline electrolyte. It is revealed that LiTFTCP additive effectively suppresses the HF generation and facilitates the formation of a robust and heat‐resistant cyano‐enriched CEI layer as well as a stable LiF‐enriched SEI layer. The favorable SEI/CEI layers greatly lessen the electrode degradation, electrolyte consumption, thermal‐induced gassing and total heat‐releasing. This work illuminates the importance of additive molecular engineering and interphase regulation in simultaneously promoting the cycling and thermal safety of LIBs with high‐nickel NCM xyz cathode and silicon‐based composite anode.
    Type of Medium: Online Resource
    ISSN: 0044-8249 , 1521-3757
    URL: Issue
    URL: Article
    DOI: 10.1002/ange.v136.5
    DOI: 10.1002/ange.202315710
    RVK:
    VA 2100
    RVK:
    VN 5020
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 505868-5
    detail.hit.zdb_id: 506609-8
    detail.hit.zdb_id: 514305-6
    detail.hit.zdb_id: 505872-7
    detail.hit.zdb_id: 1479266-7
    detail.hit.zdb_id: 505867-3
    detail.hit.zdb_id: 506259-7
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  • 8
    Online Resource
    Online Resource
    Transformed Solvation Structure of Noncoordinating Flame‐Retardant Assisted Propylene Carbonate Enabling High Voltage Li‐Ion Batteries with High Safety and Long Cyclability (Adv. Energy Mater. 28/2023)
    Wiley ; 2023
    In:  Advanced Energy Materials Vol. 13, No. 28 ( 2023-07)
    Details
    In: Advanced Energy Materials, Wiley, Vol. 13, No. 28 ( 2023-07)
    Type of Medium: Online Resource
    ISSN: 1614-6832 , 1614-6840
    URL: Issue
    URL: Article
    DOI: 10.1002/aenm.v13.28
    DOI: 10.1002/aenm.202370122
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2594556-7
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  • 9
    Online Resource
    Online Resource
    Combined Methylation and Transcriptome Analysis of Liver Injury of Nonalcoholic Fatty Liver Disease Induced by High Alcohol-Producing Klebsiella pneumoniae
    American Society for Microbiology ; 2023
    In:  Microbiology Spectrum Vol. 11, No. 3 ( 2023-06-15)
    Details
    In: Microbiology Spectrum, American Society for Microbiology, Vol. 11, No. 3 ( 2023-06-15)
    Abstract: It has been known that high alcohol-producing Klebsiella pneumoniae (HiAlc Kpn ) is one of causative agents of nonalcoholic fatty liver disease (NAFLD). However, how HiAlc Kpn promotes liver injury remains unclear. Recent findings suggest that DNA methylation might associate with the pathogenesis of NAFLD. Herein, the role of DNA methylation in HiAlc Kpn -induced liver injury was investigated. Murine models of NAFLD were established in C57BL/6N wild-type mice by gavaging HiAlc Kpn for 8 weeks. The liver injury was assessed based on the liver histopathology and biochemical indicators. In addition, DNA methylation in hepatic tissue was assessed by using dot bolt of 5-mC. RNA sequencing analysis and whole-genome bisulfite sequencing (WGBS) analysis were also performed. HiAlc Kpn significantly increased the activity of aspartate transaminase (AST), alanine transaminase (ALT), triglycerides (TGs), and glutathione (GSH), while hypomethylation was associated with liver injury in the experimental mice induced by HiAlc Kpn . The GO and KEGG pathway enrichment analysis of the transcriptome revealed that HiAlc Kpn induced fat metabolic disorders and DNA damage. The conjoint analysis of methylome and transcriptome showed that hypomethylation regulated related gene expression in signal pathways of lipid formation and circadian rhythm, including Rorα and Arntl1 genes, which may be the dominant cause of NAFLD induced by HiAlc Kpn . Data suggest that DNA hypomethylation might play an important role in liver injury of NAFLD induced by HiAlc Kpn . Which possibly provides a new sight for understanding the mechanisms of NAFLD and selecting the potential therapeutic targets. IMPORTANCE High alcohol-producing Klebsiella pneumoniae (HiAlc Kpn ) is one of causative agents of nonalcoholic fatty liver disease (NAFLD) and could induce liver damage. DNA methylation, as a common epigenetic form following contact with an etiologic agent and pathogenesis, can affect chromosome stability and transcription. We conjointly analyzed DNA methylation and transcriptome levels in the established murine models to explore the potential mechanisms for further understanding the role of DNA methylation in the liver damage of HiAlc Kpn -induced NAFLD. The analysis of the DNA methylation landscape contributes to our understanding of the entire disease process, which might be crucial in developing treatment strategies.
    Type of Medium: Online Resource
    ISSN: 2165-0497
    URL: Article
    DOI: 10.1128/spectrum.05323-22
    Language: English
    Publisher: American Society for Microbiology
    Publication Date: 2023
    detail.hit.zdb_id: 2807133-5
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  • 10
    Online Resource
    Online Resource
    Detection and Quantification of Klebsiella pneumoniae in Fecal Samples Using Digital Droplet PCR in Comparison with Real-Time PCR
    American Society for Microbiology ; 2023
    In:  Microbiology Spectrum Vol. 11, No. 4 ( 2023-08-17)
    Details
    In: Microbiology Spectrum, American Society for Microbiology, Vol. 11, No. 4 ( 2023-08-17)
    Abstract: This study aimed to develop a rapid and sensitive droplet digital PCR (ddPCR) assay for the specific detection of Klebsiella pneumoniae in fecal samples, and to evaluate its application in the clinic by comparison with real-time PCR assay and conventional microbial culture. Specific primers and a probe targeting the K. pneumoniae hemolysin ( khe ) gene were designed. Thirteen other pathogens were used to evaluate the specificity of the primers and probe. A recombinant plasmid containing the khe gene was constructed and used to assess the sensitivity, repeatability, and reproducibility of the ddPCR. Clinical fecal samples ( n  = 103) were collected and tested by the ddPCR, real-time PCR, and conventional microbial culture methods. The detection limit of ddPCR for K. pneumoniae was 1.1 copies/μL, about a 10-fold increase in sensitivity compared with real-time PCR. The ddPCR was negative for the 13 pathogens other than K. pneumoniae , confirming its high specificity. Clinical fecal samples gave a higher rate of positivity in the K. pneumoniae ddPCR assay than in analysis by real-time PCR or conventional culture. ddPCR also showed less inhibition by the inhibitor in fecal sample than real-time PCR. Thus, we established a sensitive and effective ddPCR-based assay method for K. pneumoniae . It could be a useful tool for K. pneumoniae detection in feces and may serve as a reliable method to identify causal pathogens and help guide treatment decisions. IMPORTANCE Klebsiella pneumoniae can cause a range of illnesses and has a high colonization rate in the human gut, making it crucial to develop an efficient method for detecting K. pneumoniae in fecal samples.
    Type of Medium: Online Resource
    ISSN: 2165-0497
    URL: Article
    DOI: 10.1128/spectrum.04249-22
    Language: English
    Publisher: American Society for Microbiology
    Publication Date: 2023
    detail.hit.zdb_id: 2807133-5
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