In:
Arteriosclerosis, Thrombosis, and Vascular Biology, Ovid Technologies (Wolters Kluwer Health), Vol. 26, No. 5 ( 2006-05), p. 1029-1035
Abstract:
Phospholipid lysophosphatidic acid (LPA), one component of oxidized low-density lipoprotein, regulates early growth response gene-1 (Egr-1), an important transcription factor, at the transcriptional level via transcription factors CREB and SRF in aortic smooth muscle cells. Our results imply that elevated LPA levels may, through activation of Egr-1, which regulates an array of atherogenic genes, exacerbate atheromatous lesions
Type of Medium:
Online Resource
ISSN:
1079-5642
,
1524-4636
DOI:
10.1161/01.ATV.0000214980.90567.b5
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2006
detail.hit.zdb_id:
1494427-3
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