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  • 1
    Online Resource
    Online Resource
    Writing and Using Learning Objectives
    American Society for Cell Biology (ASCB) ; 2022
    In:  CBE—Life Sciences Education Vol. 21, No. 3 ( 2022-09)
    Details
    In: CBE—Life Sciences Education, American Society for Cell Biology (ASCB), Vol. 21, No. 3 ( 2022-09)
    Abstract: Learning objectives (LOs) are used to communicate the purpose of instruction. Done well, they convey the expectations that the instructor—and by extension, the academic field—has in terms of what students should know and be able to do after completing a course of study. As a result, they help students better understand course activities and increase student performance on assessments. LOs also serve as the foundation of course design, as they help structure classroom practices and define the focus of assessments. Understanding the research can improve and refine instructor and student use of LOs. This essay describes an online, evidence-based teaching guide published by CBE—Life Sciences Education ( LSE) at http://lse.ascb.org/learning-objectives . The guide contains condensed summaries of key research findings organized by recommendations for writing and using LOs, summaries of and links to research articles and other resources, and actionable advice in the form of a checklist for instructors. In addition to describing key features of the guide, we also identify areas that warrant further empirical studies.
    Type of Medium: Online Resource
    ISSN: 1931-7913
    URL: Article
    DOI: 10.1187/cbe.22-04-0073
    Language: English
    Publisher: American Society for Cell Biology (ASCB)
    Publication Date: 2022
    detail.hit.zdb_id: 2465176-X
    SSG: 5,3
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  • 2
    Online Resource
    Online Resource
    Drug-reducing polymers decrease arterial vascular resistance without causing vasodilation
    Elsevier BV ; 2003
    In:  Journal of the American College of Cardiology Vol. 41, No. 6 ( 2003-03), p. 372-
    Details
    In: Journal of the American College of Cardiology, Elsevier BV, Vol. 41, No. 6 ( 2003-03), p. 372-
    Type of Medium: Online Resource
    ISSN: 0735-1097
    URL: Article
    DOI: 10.1016/S0735-1097(03)82179-4
    RVK:
    XA 17760
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2003
    detail.hit.zdb_id: 1468327-1
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  • 3
    Online Resource
    Online Resource
    Case Study: Creating a Video Case Study
    National Science Teachers Association (NSTA) ; 2019
    In:  Journal of College Science Teaching Vol. 048, No. 04 ( 2019)
    Details
    In: Journal of College Science Teaching, National Science Teachers Association (NSTA), Vol. 048, No. 04 ( 2019)
    Type of Medium: Online Resource
    ISSN: 0047-231X
    URL: Article
    DOI: 10.2505/4/jcst19_048_04_46
    Language: English
    Publisher: National Science Teachers Association (NSTA)
    Publication Date: 2019
    detail.hit.zdb_id: 194425-3
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  • 4
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    Online Resource
    Targeted In Vivo Labeling of Receptors for Vascular Endothelial Growth Factor : Approach to Identification of Ischemic Tissue
    Ovid Technologies (Wolters Kluwer Health) ; 2003
    In:  Circulation Vol. 108, No. 1 ( 2003-07-08), p. 97-103
    Details
    In: Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 108, No. 1 ( 2003-07-08), p. 97-103
    Abstract: Background— A method for identifying tissue experiencing hypoxic stress due to atherosclerotic vascular disease would be clinically useful. Vascular endothelial growth factor-121 (VEGF 121 ) is an angiogenic protein secreted in response to hypoxia that binds to VEGF receptors overexpressed by ischemic microvasculature. We tested the hypothesis that VEGF receptors could serve as markers for ischemic tissue and hence provide a target for imaging such tissue with radiolabeled human VEGF 121 . Methods and Results— A rabbit model of unilateral hindlimb ischemia was created by femoral artery excision (n=14). Control rabbits (n=5) underwent identical surgery without femoral excision. On postoperative day 10, rabbits were intravenously administered 100 μCi of 111 In-labeled recombinant human VEGF 121 , and biodistribution studies and planar imaging were conducted at 3, 24, and 48 hours. On postmortem gamma counting, there was greater accumulation of 111 In-labeled VEGF 121 in ischemic than in control tissue ( P 〈 0.02). Differential uptake of isotope by ischemic muscle was not seen in rabbits injected with 125 I-labeled human serum albumin (n=6). Radioactivity imaged in hindlimb regions of interest was significantly higher in ischemic muscle than in sham-operated and contralateral nonoperated hindlimb at 3 hours ( P 〈 0.02). Immunohistochemical staining confirmed upregulation of VEGF receptors in ischemic skeletal muscle. Conclusions— Identification of the ischemic state via targeted radiolabeling of hypoxia-induced angiogenic receptors is possible. This approach could be useful for monitoring the efficacy of revascularization strategies such as therapeutic angiogenesis.
    Type of Medium: Online Resource
    ISSN: 0009-7322 , 1524-4539
    URL: Article
    DOI: 10.1161/01.CIR.0000079100.38176.83
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2003
    detail.hit.zdb_id: 1466401-X
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  • 5
    Online Resource
    Online Resource
    Detection of Coronary Artery Stenosis With Power Doppler Imaging
    Ovid Technologies (Wolters Kluwer Health) ; 2001
    In:  Circulation Vol. 103, No. 21 ( 2001-05-29), p. 2624-2630
    Details
    In: Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 103, No. 21 ( 2001-05-29), p. 2624-2630
    Abstract: Background —Power Doppler is a new imaging method for detecting microbubbles during myocardial contrast echocardiography (MCE) based on the registration of variance resulting from ultrasound-induced nonlinear bubble behavior. We tested the hypothesis that power Doppler imaging can be used to quantify coronary stenoses. Methods and Results —Three left anterior descending (LAD) coronary stenoses of varying severity were created in each of 9 open-chest dogs. MCE was performed by continuous intravenous infusion of a nitrogen-filled bilayer shell microbubble, PB127, during triggered power Doppler imaging at incremental pulsing intervals. MCE and radiolabeled microsphere measurements were made at baseline and during each stenosis, with and without adenosine stress. Videointensities in the LAD and left circumflex (LCx) beds were plotted against pulsing interval and fit to a previously described exponential function modeling microbubble destruction and replenishment, which was used to derive parameters of bubble velocity (β) and peak plateau videointensity (A). Contrast defects matching the location of radiolabeled microsphere hypoperfusion were clearly seen, without need for image processing. The product of β and A was linearly related to LAD/LCx flow ( r =0.90, P 〈 0.0001) and inversely related to stenosis gradient ( r =−0.70, P 〈 0.0001). Endocardial/epicardial flow ratios were visualized and quantifiable. Conclusions —As with B-mode harmonics, a model of microbubble destruction/replenishment can be applied to power Doppler data as a means to detect a broad range of stenoses. Image clarity and the lack of attenuation or requirement for background subtraction are additional advantages of this imaging approach. Power Doppler MCE imaging holds promise for the detection of coronary artery disease.
    Type of Medium: Online Resource
    ISSN: 0009-7322 , 1524-4539
    URL: Article
    DOI: 10.1161/01.CIR.103.21.2624
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2001
    detail.hit.zdb_id: 1466401-X
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  • 6
    Online Resource
    Online Resource
    Supporting Postsecondary Educators to Develop Assessments for Student Learning Based on Backward Design
    University of California Press ; 2022
    In:  The American Biology Teacher Vol. 84, No. 8 ( 2022-10-01), p. 459-466
    Details
    In: The American Biology Teacher, University of California Press, Vol. 84, No. 8 ( 2022-10-01), p. 459-466
    Abstract: Assessment of student learning is crucial to capture accurately student understanding of core concepts and competencies as well as to provide relevant feedback for informing teaching and learning. Yet, many instructors in two-year and four-year undergraduate institutions rarely have pedagogical training to design fair instruction and assessments. This qualitative study describes changes occurring in the perspectives and practices of two postsecondary educators teaching introductory biology courses after participating in a one-day workshop on assessments and applying their new knowledge during course implementations. The assessment workshop emphasized the use of “backward design” for course planning and alignment. Learnings particularly focused on using Bloom’s taxonomy and best practices in assessment design. Data from educators’ interviews and samples of their course documents revealed encouraging findings. Even after a short intervention, the educators took initiatives to align course objectives, learning activities, and assessments. And notwithstanding the challenges arising from the COVID-19 pandemic, they also made some changes in formulating and communicating objectives with students, introduced relevant learning activities, and revised assessment questions to reflect best practices. The article discusses these findings and offers the next steps for research on supporting educators to design fair assessments and courses for undergraduate instruction.
    Type of Medium: Online Resource
    ISSN: 0002-7685 , 1938-4211
    URL: Article
    DOI: 10.1525/abt.2022.84.8.459
    Language: English
    Publisher: University of California Press
    Publication Date: 2022
    detail.hit.zdb_id: 412886-2
    detail.hit.zdb_id: 2065785-7
    SSG: 12
    SSG: 5,3
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  • 7
    Online Resource
    Online Resource
    Myocardial Contrast Echocardiography Can Be Used to Assess the Microvascular Response to Vascular Endothelial Growth Factor-121
    Ovid Technologies (Wolters Kluwer Health) ; 2002
    In:  Circulation Vol. 105, No. 6 ( 2002-02-12), p. 759-765
    Details
    In: Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 105, No. 6 ( 2002-02-12), p. 759-765
    Abstract: Background — Therapeutic angiogenesis is a new approach to treating ischemic heart disease, and the optimal method for assessing its efficacy is unclear. We used myocardial contrast echocardiography (MCE) to evaluate the therapeutic response to the angiogenic agent, vascular endothelial growth factor-121 (VEGF 121 ). Methods and Results — After placement of an ameroid constrictor (day 0) around the left anterior descending artery (LAD), dogs were given intracoronary VEGF 121 protein (108 μg, n=6) or placebo (n=6) on days 7 and 21, and subcutaneous VEGF 121 (1 mg) or placebo on days 8 to 20 and 22 to 27. On day 48, MCE was performed during rest and dobutamine stress. Videointensity ( y ) and pulsing interval ( t ) were fit to an exponential model ( y = A [1− e −βt ]) used to derive indices of red cell velocity (β) and capillary area ( A ), and parameters were compared with radiolabeled microsphere flow data. VEGF 121 treatment resulted in higher resting left anterior descending artery/left circumflex flow ratio compared with placebo ( P 〈 0.03) and improved collateral flow reserve. β was 0.94±0.37 in VEGF 121 dogs versus 0.38±0.31 in controls ( P 〈 0.02), with the greatest difference in the endocardium. The parameter A was comparable in both groups, suggesting that microvascular changes did not alter capillary cross-sectional area, and histology indicated a trend toward higher arteriolar density in VEGF 121 -treated animals. Conclusions — VEGF 121 protein improves collateral flow and reserve. MCE can evaluate the transmural location and structural and functional responses of the microvasculature to angiogenic interventions.
    Type of Medium: Online Resource
    ISSN: 0009-7322 , 1524-4539
    URL: Article
    DOI: 10.1161/hc0602.103634
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2002
    detail.hit.zdb_id: 1466401-X
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  • 8
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    Online Resource
    Advising Biology Majors about Career Choices: Resources & Information for Biology Instructors
    University of California Press ; 2017
    In:  The American Biology Teacher Vol. 79, No. 1 ( 2017-01-01), p. 14-21
    Details
    In: The American Biology Teacher, University of California Press, Vol. 79, No. 1 ( 2017-01-01), p. 14-21
    Abstract: It is essential that undergraduate biology majors are made aware of and receive guidance on career possibilities. The authors, who actively advise and teach biology majors (and future majors) at both the high school and undergraduate levels, collaborated to identify resources and methods to advise biology majors about their career choices. Multiple resources were identified. Current advising theory recommends a method of supporting students to make wise choices by considering personal vision, the kinds of professional successes desired, and individual talent development. U.S. Bureau of Labor Statistics, U.S. Census Bureau, and National Science Foundation data were analyzed to identify potential jobs that biology majors can attain. These resources and strategies should help faculty advisors and instructors inform biology majors about possible career paths.
    Type of Medium: Online Resource
    ISSN: 0002-7685 , 1938-4211
    URL: Article
    DOI: 10.1525/abt.2017.79.1.14
    Language: English
    Publisher: University of California Press
    Publication Date: 2017
    detail.hit.zdb_id: 412886-2
    detail.hit.zdb_id: 2065785-7
    SSG: 12
    SSG: 5,3
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  • 9
    Online Resource
    Online Resource
    BioInteractive’s Free Online Professional Learning Course on Evolution
    University of California Press ; 2022
    In:  The American Biology Teacher Vol. 84, No. 2 ( 2022-02-01), p. 68-74
    Details
    In: The American Biology Teacher, University of California Press, Vol. 84, No. 2 ( 2022-02-01), p. 68-74
    Abstract: Teachers are eager for professional development on teaching evolution, especially if it includes direct ties to relevant curricula and detailed lesson plans. Howard Hughes Medical Institute’s BioInteractive Online Professional Learning: Evolution course was developed to provide educators with free, in-depth, multimedia resources that highlight important scientific concepts and studies in evolution and engage participants through interactive activities that link to student resources. Our goals in the development of the asynchronous, nonfacilitated course were to (1) deepen teachers’ content knowledge of evolutionary concepts essential to NGSS and AP Biology courses, (2) increase teachers’ confidence and comfort in teaching evolution content to general biology and AP Biology students, (3) have teachers identify major evolutionary concepts in scientific studies, authentic data, or educational media used to teach evolution, and (4) assist teachers in identifying and incorporating relevant BioInteractive resources to illustrate evolutionary content and science practices in their own course(s). Our results from a postcourse survey that included pre-post retrospective confidence questions suggest that the course improved educators’ knowledge in evolution and their confidence in teaching evolutionary topics. Overall, this course provides educators the opportunity to deepen their content knowledge and obtain exciting, relevant, and reliable resources to use in their classrooms.
    Type of Medium: Online Resource
    ISSN: 0002-7685 , 1938-4211
    URL: Article
    DOI: 10.1525/abt.2022.84.2.68
    Language: English
    Publisher: University of California Press
    Publication Date: 2022
    detail.hit.zdb_id: 412886-2
    detail.hit.zdb_id: 2065785-7
    SSG: 12
    SSG: 5,3
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  • 10
    Online Resource
    Online Resource
    Ultrasound Imaging of Acute Cardiac Transplant Rejection With Microbubbles Targeted to Intercellular Adhesion Molecule-1
    Ovid Technologies (Wolters Kluwer Health) ; 2003
    In:  Circulation Vol. 108, No. 2 ( 2003-07-15), p. 218-224
    Details
    In: Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 108, No. 2 ( 2003-07-15), p. 218-224
    Abstract: Background— Noninvasive techniques for detecting acute cardiac transplant rejection are limited. We hypothesized that ultrasound contrast microbubbles targeted to the endothelial cell (EC) inflammatory marker intercellular adhesion molecule-1 (ICAM-1) would selectively bind to rejecting versus nonrejecting myocardium and that myocardial contrast echocardiography can therefore detect acute rejection. Methods and Results— Lipid-based microbubbles were conjugated to anti-rat ICAM-1 (MB ICAM ) or isotype control antibody (MB Control ). In vitro MB ICAM adhesion to cultured rat ECs, as assessed in a parallel plate flow apparatus, was greater to inflammatory versus normal ECs (11±3 versus 3±2 microbubbles/EC, P 〈 0.005). In vivo abdominal heterotopic heart transplantation was performed in rats (rejection group: Brown Norway to Lewis strain; control group: Lewis to Lewis or Brown Norway to Brown Norway). Triggered myocardial contrast echocardiography was performed during intravenous MB ICAM or MB Control (2.5×10 6 ) injection on postoperative day 5. Myocardial videointensity from adhered MB ICAM was significantly higher in rejecting (n=8) versus control (n=7) rats (10±4 versus 1±4 U, P =0.01). Postmortem histology showed normal myocardium in control rats, whereas allograft myocardium demonstrated grade III to IV rejection and strong immunohistochemical ICAM-1 staining. Conclusions— Preferential adherence of ICAM-1-targeted microbubbles to rejecting versus nonrejecting rat cardiac transplant myocardium can be detected ultrasonically. Targeted microbubbles may thus offer a noninvasive ultrasound imaging technique for the detection of acute cardiac transplant rejection and other processes characterized by endothelial dysfunction.
    Type of Medium: Online Resource
    ISSN: 0009-7322 , 1524-4539
    URL: Article
    DOI: 10.1161/01.CIR.0000080287.74762.60
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2003
    detail.hit.zdb_id: 1466401-X
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