In:
Pure and Applied Chemistry, Walter de Gruyter GmbH, Vol. 77, No. 1 ( 2005-01-01), p. 163-178
Abstract:
Due to the growing interest in small molecules that could help in understanding protein–protein interactions based on signal transduction, the demand for the generation of small-molecule libraries that are inspired by bioactive natural products has grown significantly. Many of these pathways are highly complex and present tremendous challenges with the use of classical tools. A rapid access to natural product-like small molecules having structural complexity and diversity is crucial for systematically dissecting the functions of complex protein networking and understanding cell signaling pathways. The complex nature, the three-dimensional architecture, and the number of protein binding functional groups presented in three-dimensional arrays are some of the attractive features to incorporate in small-molecule chemical probes to be used as modulators of protein function.
Type of Medium:
Online Resource
ISSN:
1365-3075
,
0033-4545
DOI:
10.1351/pac200577010163
Language:
English
Publisher:
Walter de Gruyter GmbH
Publication Date:
2005
detail.hit.zdb_id:
2022101-0
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