In:
Tumori Journal, SAGE Publications, Vol. 64, No. 2 ( 1978-04), p. 103-114
Abstract:
The sperm collected from mammary tumor virus (MTV)-carrying mice (C3H, BALB/cfC3H, BALB/cfRIII and RIII) was separately tested for mammary tumor-inducing activity in (BALB/c × C3Hf)F 1 , (BALB/c × RIIIf)F 1 , and BALB/c female recipients by i.p. injection of 0.1 ml of the sperm at 1–2 weeks or at 3 months of age. A total of 551 recipients was observed, including control mice. The results may be summarized as follows: 1) mammary tumor incidence in experiments with or without histocompatibility between sperm donor and recipient is the same; 2) bioactivity is related to the type of MTV (C3H, RIII) and to the type of recipient, not to the sperm donor; 3) the activity of RIII MTV released in the sperm appears to be less influenced by the age of recipients than is that of C3H MTV; 4) BALB/c recipients are more susceptible to C3H than to RIII sperm-released MTV; 5) (BALB/c × RIIIf)F 1 hybrids are resistant to sperm-released MTV, especially to C3H MTV infection, and show a 34% incidence of late spontaneous lymphomas inherited by the RIIIf male parent; 6) (BALB/c × C3Hf)F 1 hybrids are susceptible to both C3H and RIII sperm-released MTV and show a 30% incidence of late spontaneous mammary tumors due to genetic transmission of MTV by the C3Hf male parent.
Type of Medium:
Online Resource
ISSN:
0300-8916
,
2038-2529
DOI:
10.1177/030089167806400201
Language:
English
Publisher:
SAGE Publications
Publication Date:
1978
detail.hit.zdb_id:
280962-X
detail.hit.zdb_id:
2267832-3
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