In:
Human Heredity, S. Karger AG, Vol. 70, No. 2 ( 2010), p. 92-96
Abstract:
〈 i 〉 Objective: 〈 /i 〉 Based on a small sample of cases with schizophrenia and control individuals from an isolated population, a genome-wide association study was undertaken to find variants conferring susceptibility to this disease. 〈 i 〉 Methods: 〈 /i 〉 Standard association tests were employed, followed by newer multilocus association methods (genotype patterns). 〈 i 〉 Results: 〈 /i 〉 Individually, no variant produced a significant result. However, the best two variants (rs1360382 on chromosome 9 and rs1303 on chromosome 14) showed significantly different genotype pattern distributions between patients and control individuals. The risk genotype pattern AA-TT is highly predictive of schizophrenia, with estimated sensitivity and specificity of 1 and 0.96, respectively. 〈 i 〉 Conclusions: 〈 /i 〉 These findings support the hypothesis that schizophrenia is partly due to multiple genetic variants, each with a relatively small effect.
Type of Medium:
Online Resource
ISSN:
0001-5652
,
1423-0062
Language:
English
Publisher:
S. Karger AG
Publication Date:
2010
detail.hit.zdb_id:
1482710-4
SSG:
12
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