In:
FEBS Letters, Wiley, Vol. 531, No. 1 ( 2002-10-30), p. 103-108
Abstract:
In a comparison of embryonic brain expression patterns of lysophosphatidic acid and sphingosine 1‐phosphate receptor genes ( lpa 1–3 and s1p 1–5 , respectively), transcripts detected by Northern blot were subsequently localized using in situ hybridization. We found striking s1p 1 expression adjacent to several ventricles. Near the lateral ventricle, s1p 1 expression was temporally and spatially coincident with neurogenesis and overlapped with lpa 1 in the neocortical area. We also observed a widespread diffuse pattern for lpa 2–3 and a scattered punctate pattern for s1p 1–3 . The punctate pattern colocalized with vascular endothelial markers. Together, these results suggest that s1p 1 influences neurogenesis and s1p 1–3 influence angiogenesis in the developing brain.
Type of Medium:
Online Resource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1016/S0014-5793(02)03404-X
Language:
English
Publisher:
Wiley
Publication Date:
2002
detail.hit.zdb_id:
1460391-3
SSG:
12
Permalink