In:
Alzheimer's & Dementia, Wiley, Vol. 20, No. 4 ( 2024-04), p. 2497-2507
Abstract:
We tested the association of brain artery diameters with dementia and stroke risk in three distinct population‐based studies using conventional T2‐weighted brain magnetic resonance imaging (MRI) images. METHODS We included 8420 adults 〉 40 years old from three longitudinal population‐based studies with brain MRI scans. We estimated and meta‐analyzed the hazard ratios (HRs) of the brain and carotids and basilar diameters associated with dementia and stroke. RESULT Overall and carotid artery diameters 〉 95th percentile increased the risk for dementia by 1.74 (95% confidence interval [CI], 1.13–2.68) and 1.48 (95% CI, 1.12–1.96) fold, respectively. For stroke, meta‐analyses yielded HRs of 1.59 (95% CI, 1.04–2.42) for overall arteries and 2.11 (95% CI, 1.45–3.08) for basilar artery diameters 〉 95th percentile. DISCUSSION Individuals with dilated brain arteries are at higher risk for dementia and stroke, across distinct populations. Our findings underline the potential value of T2‐weighted brain MRI‐based brain diameter assessment in estimating the risk of dementia and stroke.
Type of Medium:
Online Resource
ISSN:
1552-5260
,
1552-5279
Language:
English
Publisher:
Wiley
Publication Date:
2024
detail.hit.zdb_id:
2211627-8
detail.hit.zdb_id:
2201940-6
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