In:
Journal of Viral Hepatitis, Wiley, Vol. 21, No. 12 ( 2014-12), p. 938-943
Abstract:
Given that low muscle mass can lead to worse health outcomes in patients with chronic infections, we assessed whether chronic hepatitis C virus ( HCV ) infection was associated with low muscle mass among US adults. We performed a cross‐sectional study of the National Health Examination and Nutrition Study (1999–2010). Chronic HCV ‐infected patients had detectable HCV RNA . Low muscle mass was defined as 〈 10th percentile for mid‐upper arm circumference ( MUAC ). Multivariable logistic regression was used to determine adjusted odds ratios (a OR s) with 95% confidence intervals ( CI s) of low muscle mass associated with chronic HCV . Among 18 513 adults, chronic HCV ‐infected patients ( n = 303) had a higher prevalence of low muscle mass than uninfected persons (13.8% vs 6.7%; a OR , 2.22; 95% CI , 1.39–3.56), and this association remained when analyses were repeated among persons without significant liver fibrosis (a OR , 2.12; 95% CI , 1.30–3.47). This study demonstrates that chronic HCV infection is associated with low muscle mass, as assessed by MUAC measurements, even in the absence of advanced liver disease.
Type of Medium:
Online Resource
ISSN:
1352-0504
,
1365-2893
DOI:
10.1111/jvh.2014.21.issue-12
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
2007924-2
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