In:
PLOS Biology, Public Library of Science (PLoS), Vol. 19, No. 1 ( 2021-1-4), p. e3001029-
Abstract:
Endosomal trafficking of receptors and associated proteins plays a critical role in signal processing. Until recently, it was thought that trafficking was shut down during cell division. Thus, remarkably, the regulation of trafficking during division remains poorly characterized. Here we delineate the role of mitotic kinases in receptor trafficking during asymmetric division. Targeted perturbations reveal that Cyclin-dependent Kinase 1 (CDK1) and Aurora Kinase promote storage of Fibroblast Growth Factor Receptors (FGFRs) by suppressing endosomal degradation and recycling pathways. As cells progress through metaphase, loss of CDK1 activity permits differential degradation and targeted recycling of stored receptors, leading to asymmetric induction. Mitotic receptor storage, as delineated in this study, may facilitate rapid reestablishment of signaling competence in nascent daughter cells. However, mutations that limit or enhance the release of stored signaling components could alter daughter cell fate or behavior thereby promoting oncogenesis.
Type of Medium:
Online Resource
ISSN:
1545-7885
DOI:
10.1371/journal.pbio.3001029
DOI:
10.1371/journal.pbio.3001029.g001
DOI:
10.1371/journal.pbio.3001029.g002
DOI:
10.1371/journal.pbio.3001029.g003
DOI:
10.1371/journal.pbio.3001029.g004
DOI:
10.1371/journal.pbio.3001029.g005
DOI:
10.1371/journal.pbio.3001029.g006
DOI:
10.1371/journal.pbio.3001029.s001
DOI:
10.1371/journal.pbio.3001029.s002
DOI:
10.1371/journal.pbio.3001029.s003
DOI:
10.1371/journal.pbio.3001029.s004
DOI:
10.1371/journal.pbio.3001029.s005
DOI:
10.1371/journal.pbio.3001029.s006
DOI:
10.1371/journal.pbio.3001029.s007
DOI:
10.1371/journal.pbio.3001029.s008
DOI:
10.1371/journal.pbio.3001029.s009
DOI:
10.1371/journal.pbio.3001029.s010
DOI:
10.1371/journal.pbio.3001029.s011
DOI:
10.1371/journal.pbio.3001029.s012
DOI:
10.1371/journal.pbio.3001029.s013
DOI:
10.1371/journal.pbio.3001029.s014
DOI:
10.1371/journal.pbio.3001029.s015
DOI:
10.1371/journal.pbio.3001029.s016
DOI:
10.1371/journal.pbio.3001029.s017
DOI:
10.1371/journal.pbio.3001029.s018
DOI:
10.1371/journal.pbio.3001029.s019
DOI:
10.1371/journal.pbio.3001029.s020
DOI:
10.1371/journal.pbio.3001029.s021
DOI:
10.1371/journal.pbio.3001029.s022
DOI:
10.1371/journal.pbio.3001029.r001
DOI:
10.1371/journal.pbio.3001029.r002
DOI:
10.1371/journal.pbio.3001029.r003
DOI:
10.1371/journal.pbio.3001029.r004
DOI:
10.1371/journal.pbio.3001029.r005
DOI:
10.1371/journal.pbio.3001029.r006
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2126773-X
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