In:
Frontiers in Neurology, Frontiers Media SA, Vol. 13 ( 2022-2-9)
Abstract:
It has been reported that in-frame FGFR3-TACC3 fusions confer to glioblastomas, IDH -wild type (GBMs, IDH wt) some unusual morphologic features, including monomorphous rounded cells with ovoid nuclei, nuclear palisading, endocrinoid network of “chicken-wire” vessels, microcalcifications and desmoplastic stroma, whose observation may predict the molecular profile of the tumor. We herein present a case of recurrent GBMs, IDH wt, exhibiting some of the above-mentioned morphological features and a molecularly-proven FGFR3-TACC3 fusion. A 56-year-old man presented to our hospital for a recurrent GBM, IDH wt, surgically treated at another center. Histologically, the tumor, in addition to the conventional GBM morphology, exhibited the following peculiar morphologic features: ( 1 ) monomorphous neoplastic cells with rounded nuclei and scant pale cytoplasm; ( 2 ) thin capillary-like vessels with “chicken-wire” pattern; ( 3 ) nuclear palisading; ( 4 ) formation of vague perivascular pseudorosettes; ( 5 ) spindled tumor cells embedded in a loose, myxoid background. Based on this unusual morphology, molecular analyses were performed and an FGFR3 exon17- TACC3 exon 10 fusion was found. The present case contributes to widening the morphologic spectrum of FGFR3-TACC3 -fused GBM, IDHwt and emphasizes that pathologists, in the presence of a GBM, IDH wt with unconventional morphology, should promptly search for this fusion gene.
Type of Medium:
Online Resource
ISSN:
1664-2295
DOI:
10.3389/fneur.2022.823015
Language:
Unknown
Publisher:
Frontiers Media SA
Publication Date:
2022
detail.hit.zdb_id:
2564214-5
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