In:
Journal of Crohn's and Colitis, Oxford University Press (OUP), ( 2023-03-29)
Abstract:
Fatigue is commonly reported by patients with inflammatory bowel disease [IBD], but the determinants of IBD-related fatigue have yet to be determined. Aims To identify the factors associated with fatigue in a large population of patients with IBD. Patients and Methods Fatigue and nine other IBD-related disability dimensions were assessed in a cohort of 1704 consecutive patients with IBD using the IBD-disk questionnaire in a cross-sectional survey of 42 French and Belgian centres. Fatigue and severe fatigue were defined as energy subscores & gt;5 and & gt;7, respectively. Determinants of fatigue were assessed using univariate and multivariate analyses (odds ratios [ORs] are provided with 95% confidence intervals). Results The prevalence rates of fatigue and severe fatigue were 54.1% and 37.1%, respectively. Both fatigue and severe fatigue were significantly higher in patients with active disease than in patients with inactive disease [64.9% vs 44.7% and 47.4% vs 28.6%, respectively; p & lt; 0.001 for both comparisons]. In the multivariate analysis stratified by age, sex, type of IBD and IBD activity, fatigue was associated with age & gt;40 years (OR = 0.71 [0.54–0.93]), female sex (OR = 1.48 [1.13–1.93] ) and IBD-related sick leave (OR = 1.61 [1.19–2.16]), and joint pain (OR = 1.60 [1.17–2.18] ), abdominal pain (OR = 1.78 [1.29–2.45]), regulating defecation (OR = 1.67 [1.20–2.32] ), education and work (OR = 1.96 [1.40–2.75]), body image (OR = 1.38 [1.02–1.86] ), sleep (OR = 3.60 [2.66–4.88]) and emotions (OR = 3.60 [2.66–4.88] ) subscores & gt;5. Conclusion Determinants of fatigue are not restricted to IBD-related factors but also include social factors, sleep and emotional disturbances, thus supporting a holistic approach to IBD patient care.
Type of Medium:
Online Resource
ISSN:
1873-9946
,
1876-4479
DOI:
10.1093/ecco-jcc/jjad060
Language:
English
Publisher:
Oxford University Press (OUP)
Publication Date:
2023
detail.hit.zdb_id:
2389631-0
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