In:
FEBS Letters, Wiley, Vol. 391, No. 1-2 ( 1996-08-05), p. 126-130
Abstract:
The multidrug resistance protein MRP has been shown to mediate the transport of glutathione S ‐conjugates across membranes. In this study we demonstrate that the glutathione S ‐conjugate of the diuretic drug ethacrynic acid, which is an efficient inhibitor of glutathione S ‐transferases, is a high‐affinity substrate and inhibitor of the glutathione S ‐transferase activity, but also pump associated with MRP. This implies that ethacrynic acid may modulate drug resistance of tumor cells not only by inhibiting glutathione S ‐transferase activity, but also by inhibiting the export of drug conjugates from the cell by MRP.
Type of Medium:
Online Resource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1016/0014-5793(96)00718-1
Language:
English
Publisher:
Wiley
Publication Date:
1996
detail.hit.zdb_id:
1460391-3
SSG:
12
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