In:
British Journal of Psychiatry, Royal College of Psychiatrists, Vol. 164, No. 6 ( 1994-06), p. 802-805
Abstract:
Nefazodone is a phenylpiperazine antidepressant with 5-HT 2 antagonism and 5-HT reuptake inhibition. Two hundred and eighty-three out-patients with a diagnosis of DSM–III–R major depression of at least one-month duration (65% ill for over 6 months), and a mean score of 24 on the 17-item Hamilton Rating Scale for Depression (HRSD), were randomised to treatment with nefazodone, imipramine, or placebo. The double-blind treatment period was 8 weeks in duration. Nefazodone's antidepressant efficacy was comparable with imipramine's, with both drug treatments significantly better than placebo in a variety of outcome measures. For example, after 8 weeks of therapy, 78% of nefazodone and 83% of imipramine but only 55% of placebo patients ( P 〈 0.01) were globally much or very much improved. Nefazodone was better tolerated than imipramine, with fewer drop-outs and a lower incidence of side-effects during treatment.
Type of Medium:
Online Resource
ISSN:
0007-1250
,
1472-1465
DOI:
10.1192/bjp.164.6.802
Language:
English
Publisher:
Royal College of Psychiatrists
Publication Date:
1994
detail.hit.zdb_id:
2021500-9
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