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  • 1
    Online Resource
    Online Resource
    3D Matrices for Enhanced Encapsulation and Controlled Release of Anti-Inflammatory Bioactive Compounds in Wound Healing
    MDPI AG ; 2023
    In:  International Journal of Molecular Sciences Vol. 24, No. 4 ( 2023-02-20), p. 4213-
    Details
    In: International Journal of Molecular Sciences, MDPI AG, Vol. 24, No. 4 ( 2023-02-20), p. 4213-
    Abstract: Current trends in the development of wound dressings are oriented towards the use of biopolymer-based materials, due to their unique properties such as non-toxicity, hydrophilicity, biocompatibility and biodegradability, properties that have advantageous therapeutic characteristics. In this regard, the present study aims to develop hydrogels based on cellulose and dextran (CD) and to reveal their anti-inflammatory performance. This purpose is achieved by incorporating plant bioactive polyphenols (PFs) in CD hydrogels. The assessments include establishing the structural characteristics using attenuated total reflection Fourier transformed infrared (ATR-FTIR) spectroscopy, the morphology by scanning electron microscopy (SEM), the swelling degree of hydrogels, the PFs incorporation/release kinetics and the hydrogels’ cytotoxicity, together with evaluation of the anti-inflammatory properties of PFs-loaded hydrogels. The results show that the presence of dextran has a positive impact on the hydrogel’s structure by decreasing the pore size at the same time as increasing the uniformity and interconnectivity of the pores. In addition, there is an increased degree of swelling and of the encapsulation capacity of PFs, with the increase of the dextran content in hydrogels. The kinetics of PFs released by hydrogels was studied according to the Korsmeyer–Peppas model, and it was observed that the transport mechanisms depend on hydrogels’ composition and morphology. Furthermore, CD hydrogels have been shown to promote cell proliferation without cytotoxicity, by successfully culturing fibroblasts and endothelial cells on CD hydrogels (over 80% viability). The anti-inflammatory tests performed in the presence of lipopolysaccharides demonstrate the anti-inflammatory properties of the PFs-loaded hydrogels. All these results provide conclusive evidence on the acceleration of wound healing by inhibiting the inflammation process and support the use of these hydrogels encapsulated with PFs in wound healing applications.
    Type of Medium: Online Resource
    ISSN: 1422-0067
    URL: Article
    DOI: 10.3390/ijms24044213
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2019364-6
    SSG: 12
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  • 2
    Online Resource
    Online Resource
    Natural Polymers in Heart Valve Tissue Engineering: Strategies, Advances and Challenges
    MDPI AG ; 2022
    In:  Biomedicines Vol. 10, No. 5 ( 2022-05-08), p. 1095-
    Details
    In: Biomedicines, MDPI AG, Vol. 10, No. 5 ( 2022-05-08), p. 1095-
    Abstract: In the history of biomedicine and biomedical devices, heart valve manufacturing techniques have undergone a spectacular evolution. However, important limitations in the development and use of these devices are known and heart valve tissue engineering has proven to be the solution to the problems faced by mechanical and prosthetic valves. The new generation of heart valves developed by tissue engineering has the ability to repair, reshape and regenerate cardiac tissue. Achieving a sustainable and functional tissue-engineered heart valve (TEHV) requires deep understanding of the complex interactions that occur among valve cells, the extracellular matrix (ECM) and the mechanical environment. Starting from this idea, the review presents a comprehensive overview related not only to the structural components of the heart valve, such as cells sources, potential materials and scaffolds fabrication, but also to the advances in the development of heart valve replacements. The focus of the review is on the recent achievements concerning the utilization of natural polymers (polysaccharides and proteins) in TEHV; thus, their extensive presentation is provided. In addition, the technological progresses in heart valve tissue engineering (HVTE) are shown, with several inherent challenges and limitations. The available strategies to design, validate and remodel heart valves are discussed in depth by a comparative analysis of in vitro, in vivo (pre-clinical models) and in situ (clinical translation) tissue engineering studies.
    Type of Medium: Online Resource
    ISSN: 2227-9059
    URL: Article
    DOI: 10.3390/biomedicines10051095
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2720867-9
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  • 3
    Online Resource
    Online Resource
    Cellulose-Based Hydrogels as Sustained Drug-Delivery Systems
    MDPI AG ; 2020
    In:  Materials Vol. 13, No. 22 ( 2020-11-21), p. 5270-
    Details
    In: Materials, MDPI AG, Vol. 13, No. 22 ( 2020-11-21), p. 5270-
    Abstract: Hydrogels, three-dimensional (3D) polymer networks, present unique properties, like biocompatibility, biodegradability, tunable mechanical properties, sensitivity to various stimuli, the capacity to encapsulate different therapeutic agents, and the ability of controlled release of the drugs. All these characteristics make hydrogels important candidates for diverse biomedical applications, one of them being drug delivery. The recent achievements of hydrogels as safe transport systems, with desired therapeutic effects and with minimum side effects, brought outstanding improvements in this area. Moreover, results from the utilization of hydrogels as target therapy strategies obtained in clinical trials are very encouraging for future applications. In this regard, the review summarizes the general concepts related to the types of hydrogel delivery systems, their properties, the main release mechanisms, and the administration pathways at different levels (oral, dermal, ocular, nasal, gastrointestinal tract, vaginal, and cancer therapy). After a general presentation, the review is focused on recent advances in the design, preparation and applications of innovative cellulose-based hydrogels in controlled drug delivery.
    Type of Medium: Online Resource
    ISSN: 1996-1944
    URL: Article
    DOI: 10.3390/ma13225270
    Language: English
    Publisher: MDPI AG
    Publication Date: 2020
    detail.hit.zdb_id: 2487261-1
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  • 4
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    Influence of Gel Stage from Cellulose Dissolution in NaOH-Water System on the Performances of Cellulose Allomorphs-Based Hydrogels
    MDPI AG ; 2022
    In:  Gels Vol. 8, No. 7 ( 2022-06-29), p. 410-
    Details
    In: Gels, MDPI AG, Vol. 8, No. 7 ( 2022-06-29), p. 410-
    Abstract: Novel hydrogels were prepared starting from different cellulose allomorphs (cellulose I, II, and III), through a swelling stage in 8.5% NaOH aqueous solution, followed by freezing at low temperature (−30 °C), for 24 h. After thawing at room temperature, the obtained gels were chemical cross-linked with epichlorohydrin (ECH), at 85 °C. The swelling degrees of the hydrogels were investigated, and a complex dependence on the type of the cellulose allomorph was found. Moreover, the gel stage has been shown to play a key role in the design of hydrogels with different performances, following the series: H-CII 〉 H-CI 〉 H-CIII. The correlations between the allomorph type and the morphological characteristics of hydrogels were established by scanning electron microscopy (SEM). The hydrogel H-CII showed the biggest homogeneous pores, while H-CIII had the most compacted pores network, with small interconnected pores. The rheological studies were performed in similar shear regimes, and a close correlation between the strength of the gel structure and the size of the gel fragments was observed. In the case of hydrogels, it has been shown that H-CII is softer, with a lower resistance of the hydrogel (G′) above the oscillation frequencies tested, but it maintains its stable structure, while H-CIII has the highest modulus of storage and loss compared to H-CI and H-CII, having a stronger and more rigid structure. The X-ray diffraction (XRD) method showed that the crystalline organization of each type of allomorph possesses a distinctive diffraction pattern, and, in addition, the chemically cross-linking reaction has been proved by a strong decrease of the crystallinity. Attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy provided clear evidence of the chemical cross-linking of cellulose allomorphs with ECH, by the alteration of the crystal structure of cellulose allomorphs and by the formation of new ether bands.
    Type of Medium: Online Resource
    ISSN: 2310-2861
    URL: Article
    DOI: 10.3390/gels8070410
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2813982-3
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  • 5
    Online Resource
    Online Resource
    One-Step Preparation of Carboxymethyl Cellulose—Phytic Acid Hydrogels with Potential for Biomedical Applications
    MDPI AG ; 2022
    In:  Gels Vol. 8, No. 10 ( 2022-10-12), p. 647-
    Details
    In: Gels, MDPI AG, Vol. 8, No. 10 ( 2022-10-12), p. 647-
    Abstract: Hydrogels based on natural, biodegradable materials have gained considerable interest in the medical field due to their improved drug delivery profiles and tissue-mimicking architecture. In this regard, this study was devoted to the preparation and characterization of new physically crosslinked hydrogels based on carboxymethyl cellulose and an unconventional crosslinking agent, phytic acid. Phytic acid, in addition to its antioxidant and antibacterial effects, can improve the biological properties and stability of gels, without adding toxicity. Fourier transform infrared (FTIR) spectroscopy, rheological studies and thermal analysis confirmed the hydrogel formation. The influence of the ratio between the cellulose derivative and the crosslinker upon the morphological structure and water uptake was evidenced by scanning electron microscopy (SEM) and swelling measurements in simulated body fluids. Furthermore, procaine was entrapped within the hydrogels and used as a model drug for in vitro studies, which highlighted the dependence of the drug release on the phytic acid content of the matrix. The materials demonstrated antibacterial effects against Escherichia coli and Staphylococcus aureus bacteria. The biocompatibility was assessed on fibroblast cells, and according to our results, hydrogels can improve cell viability highlighting the potential of these systems as therapeutic scaffolds for skin tissue engineering.
    Type of Medium: Online Resource
    ISSN: 2310-2861
    URL: Article
    DOI: 10.3390/gels8100647
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2813982-3
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  • 6
    Online Resource
    Online Resource
    Environmentally Friendly Polylactic Acid/Modified Lignosulfonate Biocomposites
    Springer Science and Business Media LLC ; 2017
    In:  Journal of Polymers and the Environment Vol. 25, No. 3 ( 2017-9), p. 884-902
    Details
    In: Journal of Polymers and the Environment, Springer Science and Business Media LLC, Vol. 25, No. 3 ( 2017-9), p. 884-902
    Type of Medium: Online Resource
    ISSN: 1566-2543 , 1572-8900
    URL: Article
    DOI: 10.1007/s10924-016-0868-2
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2017
    detail.hit.zdb_id: 2017207-2
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  • 7
    Online Resource
    Online Resource
    Aromatherapeutic and Antibacterial Properties of Cotton Materials Treated with Emulsions Containing Peppermint Essential Oil (Menthae piperitae aetheroleum)
    MDPI AG ; 2023
    In:  Polymers Vol. 15, No. 10 ( 2023-05-17), p. 2348-
    Details
    In: Polymers, MDPI AG, Vol. 15, No. 10 ( 2023-05-17), p. 2348-
    Abstract: The objective of the work was to obtain materials with aromatherapeutic and antibacterial properties by applying emulsions based on peppermint essential oil (PEO) onto cotton fabric. For this purpose, some emulsions based on PEO incorporated in various matrices (chitosan + gelatin + beeswax; chitosan + beeswax; gelatin + beeswax and gelatin + chitosan) were prepared. Tween 80 was used as a synthetic emulsifier. The influence of the nature of matrices and of the concentration of Tween 80 on the stability of the emulsions was evaluated by the creaming indices. The materials treated with the stable emulsions were analyzed in terms of sensory activity, of the comfort characteristics, and of the gradual release of the PEO in the artificial perspiration solution. The sum of volatile components retained by samples after exposure to air was determined by GC-MS. The results regarding antibacterial activity showed that materials treated with emulsions have a good inhibitory effect on S. aureus (diameters of the inhibition zones between 53.6 and 64.0 mm) and on E. coli (diameters of the inhibition zones between 38.3 and 64.0 mm). Our data suggest that by applying peppermint-oil-based emulsions on a cotton support, aromatherapeutic patches, bandages and dressings with antibacterial properties can be obtained.
    Type of Medium: Online Resource
    ISSN: 2073-4360
    URL: Article
    DOI: 10.3390/polym15102348
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2527146-5
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  • 8
    Online Resource
    Online Resource
    Synthesis and characterization of some cellulose/chondroitin sulphate hydrogels and their evaluation as carriers for drug delivery
    Elsevier BV ; 2012
    In:  Carbohydrate Polymers Vol. 87, No. 1 ( 2012-01), p. 721-729
    Details
    In: Carbohydrate Polymers, Elsevier BV, Vol. 87, No. 1 ( 2012-01), p. 721-729
    Type of Medium: Online Resource
    ISSN: 0144-8617
    URL: Article
    DOI: 10.1016/j.carbpol.2011.08.052
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2012
    detail.hit.zdb_id: 1501516-6
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  • 9
    Online Resource
    Online Resource
    Semi-interpenetrating Polymer Networks Containing Polysaccharides. I Xanthan/Lignin Networks
    SAGE Publications ; 2007
    In:  High Performance Polymers Vol. 19, No. 5-6 ( 2007-10), p. 603-620
    Details
    In: High Performance Polymers, SAGE Publications, Vol. 19, No. 5-6 ( 2007-10), p. 603-620
    Abstract: The polysaccharides are important materials in food, pharmaceutical, cosmetic and related biomedical applications. Xanthan gum is a microbial polysaccharide of great commercial significance. It is well known as one of the best thickening polymers due to its high intrinsic stiffness related to the helical conformation stabilized in the presence of excess salt. It is used in a wide variety of foods for a number of important reasons, including emulsion stabilization, temperature stability, compatibility with food ingredients, and its pseudoplastic rheological properties. Due to its properties in thickening aqueous solutions, as a dispersing agent, and stabilizer of emulsions and suspensions, xanthan gum is used in pharmaceutical formulations, cosmetics, and agricultural products, as well as in textile printing pastes, ceramic glazes, slurry explosive formulations, and rust removers. In this work the crosslinking of a mixture of xanthan and lignins in the presence of the epichlorohydrin, leading to superabsorbant hydrogels with high swelling rate in aqueous mediums, was studied. The swelling properties of these composite hydrogels were investigated. Three different types of lignin have been used namely: aspen wood lignin (L), annual fiber crop lignin (GL) and lignin epoxy-modified resin (LER). Semi-interpenetrating polymer network hydrogels in various ratios were prepared. The influence of gravimetric ratio between components of the semi-interpenetrating polymer networks, as well as the kinetics of water sorption will be discussed. The maximum swelling degree of the hydrogels and the swelling rate constant were determined as a function of the hydrogel's composition. It has been established that the nature of lignin significantly influences swelling process, the chemical modified lignin having a particular behavior.
    Type of Medium: Online Resource
    ISSN: 0954-0083 , 1361-6412
    URL: Article
    DOI: 10.1177/0954008307081202
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2007
    detail.hit.zdb_id: 1483713-4
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