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  • 1
    Online Resource
    Online Resource
    Overview of Pancreatic Cancer Epidemiology in Europe and Recommendations for Screening in High-Risk Populations
    MDPI AG ; 2023
    In:  Cancers Vol. 15, No. 14 ( 2023-07-15), p. 3634-
    Details
    In: Cancers, MDPI AG, Vol. 15, No. 14 ( 2023-07-15), p. 3634-
    Abstract: Pancreatic cancer is the seventh most common cause of death in the group of oncological diseases. Due to the asymptomatic course, early diagnosis is difficult. Currently, early detection methods are only used in high-risk groups. A literature review based on the available results of observational studies on patients with pancreatic cancer and people from high-risk groups was used to summarize the knowledge on risk factors. The GLOBOCAN 2020 data were used to assess the epidemiological situation in Europe. A summary of screening recommendations was prepared based on the available documents from medical organizations and associations. Pancreatic cancer risk factors are divided into two main groups: non-modifiable factors, e.g., hereditary factors and age, which increase the risk of developing this disease, and modifiable factors—BMI, smoking, and alcohol consumption. Hereditary factors account for 10% of pancreatic cancer cases. The highly specialized methods of early detection, (MRI, CT, or EUS) are used for screening high-risk populations. Of all the imaging methods, EUS is considered the most sensitive for pancreatic cancer and allows an accurate assessment of the size of even small lesions ( 〈 30 mm) and the extent of tumour infiltration into blood vessels. The available studies vary on the level of sensitivity and specificity of these methods for the diagnosis of pancreatic cancer. EUS, MRI, and CT are also expensive procedures and in some patients can be invasive, which is one of the arguments against the introduction of population screening programs based on imaging methods. Therefore, it is important to look for viable solutions that would improve early detection. This is important from the point of view of healthcare systems in Europe, where almost 29% of all global pancreatic cancer cases are reported.
    Type of Medium: Online Resource
    ISSN: 2072-6694
    URL: Article
    DOI: 10.3390/cancers15143634
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2527080-1
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  • 2
    Online Resource
    Online Resource
    Management of Metastatic Pancreatic Cancer—Comparison of Global Guidelines over the Last 5 Years
    MDPI AG ; 2023
    In:  Cancers Vol. 15, No. 17 ( 2023-09-02), p. 4400-
    Details
    In: Cancers, MDPI AG, Vol. 15, No. 17 ( 2023-09-02), p. 4400-
    Abstract: Pancreatic cancer (PC) is usually diagnosed at an advanced stage of its development, which results in lower overall survival (OS). Prognosis is also poor even with curative-intent surgery. Approximately 80% of patients with localized PDAC have micrometastases at the time of diagnosis, which leads to a worse prognosis than in other cancers. The objective of this study is to present the progress in the treatment of metastatic pancreatic cancer based on the recommendations of oncological scientific societies, such as ESMO, NCCN, ASCO, NICE and SEOM, over the last 5 years. Combined FOLFIRINOX therapy is mostly a recommended therapy among patients with good performance statuses, while gemcitabine is recommended for more fragile patients as a first-line treatment. The newest guidelines suggest that molecular profiling of the tumor should be the first step in determining the course of treatment. The use of modern molecular therapies in patients with specific gene mutations should extend the survival of patients with this disease.
    Type of Medium: Online Resource
    ISSN: 2072-6694
    URL: Article
    DOI: 10.3390/cancers15174400
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2527080-1
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  • 3
    Online Resource
    Online Resource
    Quality of Life in Patients with Pancreatic Cancer—A Literature Review
    MDPI AG ; 2023
    In:  International Journal of Environmental Research and Public Health Vol. 20, No. 6 ( 2023-03-10), p. 4895-
    Details
    In: International Journal of Environmental Research and Public Health, MDPI AG, Vol. 20, No. 6 ( 2023-03-10), p. 4895-
    Abstract: Pancreatic cancer is the malignant disease with the highest mortality rate, and it ranks third in the world after lung and colon cancer. Identified factors that increase the risk of developing pancreatic cancer include chronic pancreatitis, radiation therapy to the pancreatic area due to another cancer, diabetes mellitus, obesity, smoking, and age. The objective of this study was to present the current state of knowledge on the quality of life of patients diagnosed with pancreatic cancer, factors that determine QoL, and ways of coping with the disease. The low curability and low survival rates of pancreatic cancer significantly affect the quality of life of patients, often in the form of significant deterioration, especially in terms of mental changes, cognitive functions, and coping with the disease. Cognitive decline with comorbid depression is also typical for patients with this type of cancer. Research has shown that the health-related quality of life of patients with pancreatic cancer is low, so further research is needed to improve the situation in this area.
    Type of Medium: Online Resource
    ISSN: 1660-4601
    URL: Article
    DOI: 10.3390/ijerph20064895
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2175195-X
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  • 4
    Online Resource
    Online Resource
    The impact of the SARS-CoV-2 virus pandemic on the hygiene habits of the Poles
    Fundacja Pro Medicina ; 2021
    In:  Journal of Health Policy & Outcomes Research , No. 2 ( 2021-07-28), p. 18-26
    Details
    In: Journal of Health Policy & Outcomes Research, Fundacja Pro Medicina, , No. 2 ( 2021-07-28), p. 18-26
    Abstract: Background The objective of the study was to learn about and evaluate the hygienic habits of the Poles. There were also specific objectives defined, related to the change of the habits during the pandemic: 1. 1. perform basic hygiene activities and those aimed at reducing the risk of contracting COVID-19, 2. 2. use of hygiene utensils. Material and methods The study was conducted in two editions. The first edition took place at the beginning of the pandemic in Poland (April 2020) and the second one after another 8 months (November 2020). A total of 549 people took part in the study, including 412 women and 137 men. In the study (survey) a specifically designed questionnaire consisting of 14 closed questions was used. The questions concerned three subject areas: 1. 1. Possession and use of hygienic utensils, 2. 2. Habits and activities related to COVID-19 pandemic, 3. 3. Basic activities of personal hygiene. Within each part, the existence of a correlation between the first edition and the second round of the study was examined. Results Most of the respondents had personal hygiene equipment, in the second edition they also had a toothbrush (p=0.0367). The habits of the respondents regarding the additional activities related to oral hygiene changed significantly (p=0.0315), the percentage of people using only dental floss increased along with decreasing percentage of people using mouthwash solely. There was also a significant decrease in the percentage of respondents using chewing gum (p=0.0044). In addition, it was found that the frequency of hand washing during the pandemic increased and the time of using antibacterial fluids lengthened significantly (p=0.000). Along with the course of the pandemic, the subjects stopped adhering to the recommendations related to the manner of sneezing and coughing. The number of people sneezing in their elbow decreased significantly (p=0.0016), while the number of people sneezing in their hands increased simultaneously (p=0.000). Along with the course of the pandemic, the number of people who do not take their bath every day has also decreased (p=0.0023), which may be related to the prolonged period of social isolation. Conclusions In the light of the obtained results, it can be noticed that the respondents do not fully comply with the requirements of the sanitary regime and they apply the guidelines selectively and for a short time. The behavioural patterns that may be identified by the subjects as related to their personal epidemic safety seem to be more persistent. These behavioural patterns indicate the need for more frequent and systematic educational campaigns on epidemiological safety and hygiene.
    Type of Medium: Online Resource
    ISSN: 2299-1247
    URL: Article
    DOI: 10.7365/JHPOR.2021.2.3
    Language: English
    Publisher: Fundacja Pro Medicina
    Publication Date: 2021
    detail.hit.zdb_id: 2940169-0
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  • 5
    Online Resource
    Online Resource
    Comparison of US and EU Prices for Orphan Drugs in the Perspective of the Considered US Orphan Drugs Act Modifications and Discussed Price-Regulation Mechanisms Adjustments in US and European Union
    MDPI AG ; 2022
    In:  International Journal of Environmental Research and Public Health Vol. 19, No. 19 ( 2022-09-24), p. 12098-
    Details
    In: International Journal of Environmental Research and Public Health, MDPI AG, Vol. 19, No. 19 ( 2022-09-24), p. 12098-
    Abstract: The 2019 worldwide sales of Orphan Drugs were estimated at $136 billion USD, which constituted 16% of the global pharmaceutical prescription market and is expected to grow by 12% in the next 5 years. A better understanding of Orphan Drug pricing may contribute to on-going discussions on Orphan Drug Act (ODA) corrections in US or modifications of price setting mechanisms in EU. The objective of the study was comparison and analysis of the prices of Orphan Drugs in US and EU. All drugs with Orphan Drug status were compared in the US and EU. For the US prices, the US Department of Veterans Affairs (VA) was sourced. The EU List Prices came from six EU countries: Denmark, France, Germany, Greece, Poland, Spain. We found US prices to be higher than the six selected EU countries. The average Price Ratio was 1.64. The prices across EU countries were more homogeneous, while the number of the reimbursed and therefore available to patient medicines varied and was correlated with GDP per capita r = 0.87. Considered implementation of the External Reference Price system in US may generate significant savings in the US but may result in upward pressure on pricing of Orphan Drugs in EU. Centralization of the Orphan Drugs pricing negotiations in EU may prevent such development and offer a win-win opportunity for all involved parties.
    Type of Medium: Online Resource
    ISSN: 1660-4601
    URL: Article
    DOI: 10.3390/ijerph191912098
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2175195-X
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  • 6
    Online Resource
    Online Resource
    Wieloaspektowe postępowanie w diagnostyce i terapii chorób śródmiąższowych płuc
    Poznan University of Medical Sciences ; 2019
    In:  Polski Przegląd Nauk o Zdrowiu Vol. 60, No. 3 ( 2019-12-23), p. 232-237
    Details
    In: Polski Przegląd Nauk o Zdrowiu, Poznan University of Medical Sciences, Vol. 60, No. 3 ( 2019-12-23), p. 232-237
    Type of Medium: Online Resource
    ISSN: 1643-3203 , 2544-283X
    URL: Journal
    URL: Article
    DOI: 10.20883/issn.1643-3203
    DOI: 10.20883/ppnoz.2019.53
    Language: Unknown
    Publisher: Poznan University of Medical Sciences
    Publication Date: 2019
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  • 7
    Online Resource
    Online Resource
    How COVID-19 Broke the Barriers Related to the Implementation of Telecare—Patients’ Experiences with a New form of Providing Health Services in Primary Health Care
    MDPI AG ; 2023
    In:  Healthcare Vol. 11, No. 4 ( 2023-02-08), p. 497-
    Details
    In: Healthcare, MDPI AG, Vol. 11, No. 4 ( 2023-02-08), p. 497-
    Abstract: Background: The COVID-19 pandemic has significantly contributed to accelerating the development of telemedicine and eHealth. The main aim of this study was to assess the attitudes of patients towards remote care implemented in general practice (GP) during the pandemic. Methods: The study was a pilot study conducted in March–April 2021, considering technical aspects of using teleconsultations, and evaluating the difficulties, advantages and disadvantages for patients. When assessing opinions, a simple Likert scale was used, where a value of 1 meant the worst possible assessment or strong disagreement and the upper value the best or full agreement of the respondent. Results: The study covered 408 respondents. Their biggest organizational challenge reaching GPs by telephone, regardless of the patients’ home location (p = 0.23698). Obtaining e-documents was not problematic but was rated as worse by men (p = 0.048295). Respondents rated the overall effectiveness of teleconsultations more highly if they could speak directly with a doctor (p = 0.0005). There were no differences in willingness to recommend teleconsultations based on gender (p = 0.2432), place of residence (p = 0.7878), age (p = 0.290355) or education (p = 0.9109), but people assessing the overall effectiveness of telemedicine more highly were more willing to recommend it (p = 0.000). Conclusions: Respondents assess teleconsultations in a differentiated way, noticing both positive and negative features of the remote form of providing health services.
    Type of Medium: Online Resource
    ISSN: 2227-9032
    URL: Article
    DOI: 10.3390/healthcare11040497
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2721009-1
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  • 8
    Online Resource
    Online Resource
    Value-Based Integrated Care (VBIC) Concept Implementation in a Real-World Setting—Problem-Based Analysis of Barriers and Challenges
    MDPI AG ; 2023
    In:  Healthcare Vol. 11, No. 8 ( 2023-04-12), p. 1110-
    Details
    In: Healthcare, MDPI AG, Vol. 11, No. 8 ( 2023-04-12), p. 1110-
    Abstract: Healthcare effectiveness measurement and value in health have been common topics in public health literature since 2006 when value-based healthcare (VBHC) was first defined by Porter and Teisberg. The aim of this study was to identify the barriers and challenges related to the implementation of VBHC solutions in the example of Poland. A case presentation was used as a method. The national integrated care programs (KOS-Infarction, POZ-Plus, and comprehensive treatment of chronic wounds) were used to present general challenges, along with the Integrated Care Model (ICM) for patients with advanced chronic obstructive pulmonary disease (COPD), to determine specific difficulties. ICM has been operating since 2012 in Gdańsk and gradually adapted the value-based integrated care (VBIC) approach. An analysis of the available data showed that the greatest difficulties related to the implementation of the VBHC and VBIC concepts are a lack of legal and reimbursement solutions, staff shortages, a lack of educational standards for some members of the multidisciplinary team, and insufficient awareness of the role of integrated care. As the level of preparation to implement VBHC policies varies between individual countries, the conclusions drawn from the experience of ICM and other Polish projects may be a valuable voice in discussion.
    Type of Medium: Online Resource
    ISSN: 2227-9032
    URL: Article
    DOI: 10.3390/healthcare11081110
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2721009-1
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  • 9
    Online Resource
    Online Resource
    Treatment Costs and Social Burden of Pancreatic Cancer
    MDPI AG ; 2023
    In:  Cancers Vol. 15, No. 6 ( 2023-03-22), p. 1911-
    Details
    In: Cancers, MDPI AG, Vol. 15, No. 6 ( 2023-03-22), p. 1911-
    Abstract: (1) Background: Pancreatic cancer is the cancer with the third-highest mortality rate, and forecasts indicate its growing share in morbidity. The basis of treatment is inpatient chemotherapy and there is a strong focus on palliative care. (2) Methods: A literature review was conducted based on the rapid review methodology in PubMed and Cochrane databases. The search was supplemented with publications from the snowball search. Qualitative assessment of included publications was performed using AMSTAR2 modified scheme. (3) Results: The review included 17 publications, of which majority concerned direct costs related to the adopted treatment regimen. Most of the publications focused on comparing the cost-effectiveness of drug therapies and the costs of palliative treatment. Other publications concerned indirect costs generated by pancreatic cancer. They particularly focused on the economic burden of lost productivity due to sickness absence. (4) Conclusion: The increase in the incidence of pancreatic cancer translates into an increase in the costs of the health care system and indirect costs. Due to the significant share of hospitalization in the health care structure, direct costs are increasing. The inpatient treatment regimen and side effects translate into a loss of productivity for patients with pancreatic cancer. Among gastrointestinal cancers, pancreatic cancer generates the second largest indirect costs, although it has a much lower incidence rate than the dominant colorectal cancer. This indicates a significant problem of the economic burden of this cancer.
    Type of Medium: Online Resource
    ISSN: 2072-6694
    URL: Article
    DOI: 10.3390/cancers15061911
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2527080-1
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  • 10
    Online Resource
    Online Resource
    Evaluation of Health Pattern and Stress Levels among Patients Undergoing Alcohol Addiction Treatment—A Cross Sectional Study
    MDPI AG ; 2023
    In:  Journal of Clinical Medicine Vol. 12, No. 15 ( 2023-07-28), p. 4959-
    Details
    In: Journal of Clinical Medicine, MDPI AG, Vol. 12, No. 15 ( 2023-07-28), p. 4959-
    Abstract: Alcohol consumption is linked to over 200 diseases and injuries. It is also classified as a risk factor for several types of neoplasms as well as infectious diseases (i.e., HIV and tuberculosis). In 2019, among people aged 25 to 49, alcohol use was the leading risk factor for attributable burden of disease. There are many factors that affect alcohol drinking patterns such as social and economic status, social norms, cultural customs, availability of alcohol, etc. Stress also plays a significant role in the process of developing alcohol addiction. The aim of our study was to examine health patterns and stress levels among patients undergoing alcohol addiction treatment. The study sample consisted of 104 patients who were treated in a hospital ward due to alcohol dependence. Three standardized questionnaire tools were used to measure the sense of coherence and the level of stress among those patients. The main results suggest that the level of perceived stress correlated negatively with all dimensions of sense of coherence and all indicators of health behaviors, however, age was positively correlated with positive mental attitude, proper eating habits, and health behaviors. In conclusion, it is worth noting that developing patterns for positive health behaviors will make it possible to avoid alcohol dependence or reinforce the treatment results if alcohol dependence syndrome occurs.
    Type of Medium: Online Resource
    ISSN: 2077-0383
    URL: Article
    DOI: 10.3390/jcm12154959
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2662592-1
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