In:
International Journal of Cancer, Wiley, Vol. 142, No. 3 ( 2018-02), p. 573-583
Abstract:
What's new? While ionizing radiation is an established risk factor for breast cancer, little is known about mechanisms of radiation‐specific breast carcinogenesis related to low‐dose exposure. Here, investigation of molecular changes in breast cancers from female post‐Chernobyl clean‐up workers exposed to radiation revealed two radiation‐specific molecular markers: increased expression of hsa‐miR‐26b‐5p and downregulation of its target TRPS1. In human radiation‐transformed breast cells, TRPS1 knockdown was found to be associated with enrichment of DNA repair, cell cycle, mitosis, angiogenesis, migration and EMT pathways. Further investigation of specific markers could facilitate the identification of radiation‐induced breast cancer and potentially provide a basis for individualized therapy.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
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