In:
Experimental Dermatology, Wiley, Vol. 27, No. 2 ( 2018-02), p. 201-204
Abstract:
In this study, we aimed to investigate the anti‐melanoma effects and the JAK 2/ STAT 3 pathway‐related mechanism of action of atractylenolide I in human melanoma cells. Our results showed that atractylenolide I effectively reduced viability, induced apoptosis and inhibited migration of melanoma cells. Meanwhile, atractylenolide I decreased the protein expression levels of phospho‐ JAK 2 and phospho‐ STAT 3, and in turn downregulated the mRNA levels of STAT 3‐targeted genes, including Bcl‐ xL , MMP ‐2 and MMP ‐9. Furthermore, the cytotoxic effect of atractylenolide I was attenuated in STAT 3‐overactivated A375 cells. These findings indicate that inhibition of JAK 2/ STAT 3 signalling contributes to the anti‐melanoma effects of atractylenolide I.
Type of Medium:
Online Resource
ISSN:
0906-6705
,
1600-0625
DOI:
10.1111/exd.2018.27.issue-2
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2026228-0
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