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  • 1
    Online Resource
    Online Resource
    NEURO/MEDICAL ONCOLOGY
    Oxford University Press (OUP) ; 2013
    In:  Neuro-Oncology Vol. 15, No. suppl 3 ( 2013-11-01), p. iii98-iii135
    Details
    In: Neuro-Oncology, Oxford University Press (OUP), Vol. 15, No. suppl 3 ( 2013-11-01), p. iii98-iii135
    Type of Medium: Online Resource
    ISSN: 1522-8517 , 1523-5866
    URL: Article
    DOI: 10.1093/neuonc/not182
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2013
    detail.hit.zdb_id: 2094060-9
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  • 2
    Online Resource
    Online Resource
    MEDICAL RADIATION THERAPIES
    Oxford University Press (OUP) ; 2013
    In:  Neuro-Oncology Vol. 15, No. suppl 3 ( 2013-11-01), p. iii75-iii84
    Details
    In: Neuro-Oncology, Oxford University Press (OUP), Vol. 15, No. suppl 3 ( 2013-11-01), p. iii75-iii84
    Type of Medium: Online Resource
    ISSN: 1522-8517 , 1523-5866
    URL: Article
    DOI: 10.1093/neuonc/not179
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2013
    detail.hit.zdb_id: 2094060-9
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  • 3
    Online Resource
    Online Resource
    Genetic diversity fuels gene discovery for tobacco and alcohol use
    Springer Science and Business Media LLC ; 2022
    In:  Nature Vol. 612, No. 7941 ( 2022-12-22), p. 720-724
    Details
    In: Nature, Springer Science and Business Media LLC, Vol. 612, No. 7941 ( 2022-12-22), p. 720-724
    Abstract: Tobacco and alcohol use are heritable behaviours associated with 15% and 5.3% of worldwide deaths, respectively, due largely to broad increased risk for disease and injury 1–4 . These substances are used across the globe, yet genome-wide association studies have focused largely on individuals of European ancestries 5 . Here we leveraged global genetic diversity across 3.4 million individuals from four major clines of global ancestry (approximately 21% non-European) to power the discovery and fine-mapping of genomic loci associated with tobacco and alcohol use, to inform function of these loci via ancestry-aware transcriptome-wide association studies, and to evaluate the genetic architecture and predictive power of polygenic risk within and across populations. We found that increases in sample size and genetic diversity improved locus identification and fine-mapping resolution, and that a large majority of the 3,823 associated variants (from 2,143 loci) showed consistent effect sizes across ancestry dimensions. However, polygenic risk scores developed in one ancestry performed poorly in others, highlighting the continued need to increase sample sizes of diverse ancestries to realize any potential benefit of polygenic prediction.
    Type of Medium: Online Resource
    ISSN: 0028-0836 , 1476-4687
    URL: Article
    DOI: 10.1038/s41586-022-05477-4
    RVK:
    TA 1000
    RVK:
    UA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 120714-3
    detail.hit.zdb_id: 1413423-8
    SSG: 11
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  • 4
    Online Resource
    Online Resource
    The mass of β Pictoris c from β Pictoris b orbital motion
    EDP Sciences ; 2021
    In:  Astronomy & Astrophysics Vol. 654 ( 2021-10), p. L2-
    Details
    In: Astronomy & Astrophysics, EDP Sciences, Vol. 654 ( 2021-10), p. L2-
    Abstract: Aims. We aim to demonstrate that the presence and mass of an exoplanet can now be effectively derived from the astrometry of another exoplanet. Methods. We combined previous astrometry of β Pictoris b with a new set of observations from the GRAVITY interferometer. The orbital motion of β Pictoris b is fit using Markov chain Monte Carlo simulations in Jacobi coordinates. The inner planet, β Pictoris c, was also reobserved at a separation of 96 mas, confirming the previous orbital estimations. Results. From the astrometry of planet b only, we can (i) detect the presence of β Pictoris c and (ii) constrain its mass to 10.04 −3.10 +4.53 M Jup . If one adds the astrometry of β Pictoris c, the mass is narrowed down to 9.15 −1.06 +1.08 M Jup . The inclusion of radial velocity measurements does not affect the orbital parameters significantly, but it does slightly decrease the mass estimate to 8.89 −0.75 +0.75 M Jup . With a semimajor axis of 2.68 ± 0.02 au, a period of 1221 ± 15 days, and an eccentricity of 0.32 ± 0.02, the orbital parameters of β Pictoris c are now constrained as precisely as those of β Pictoris b. The orbital configuration is compatible with a high-order mean-motion resonance (7:1). The impact of the resonance on the planets’ dynamics would then be negligible with respect to the secular perturbations, which might have played an important role in the eccentricity excitation of the outer planet.
    Type of Medium: Online Resource
    ISSN: 0004-6361 , 1432-0746
    URL: Article
    DOI: 10.1051/0004-6361/202141889
    RVK:
    UA 1000
    RVK:
    US 1090
    Language: English
    Publisher: EDP Sciences
    Publication Date: 2021
    detail.hit.zdb_id: 1458466-9
    SSG: 16,12
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  • 5
    Online Resource
    Online Resource
    Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19
    Springer Science and Business Media LLC ; 2023
    In:  Genome Medicine Vol. 15, No. 1 ( 2023-04-05)
    Details
    In: Genome Medicine, Springer Science and Business Media LLC, Vol. 15, No. 1 ( 2023-04-05)
    Abstract: We previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15–20% of cases of life-threatening COVID-19 in unvaccinated patients. Therefore, the determinants of life-threatening COVID-19 remain to be identified in ~ 80% of cases. Methods We report here a genome-wide rare variant burden association analysis in 3269 unvaccinated patients with life-threatening COVID-19, and 1373 unvaccinated SARS-CoV-2-infected individuals without pneumonia. Among the 928 patients tested for autoantibodies against type I IFN, a quarter (234) were positive and were excluded. Results No gene reached genome-wide significance. Under a recessive model, the most significant gene with at-risk variants was TLR7 , with an OR of 27.68 (95%CI 1.5–528.7, P  = 1.1 × 10 −4 ) for biochemically loss-of-function (bLOF) variants. We replicated the enrichment in rare predicted LOF (pLOF) variants at 13 influenza susceptibility loci involved in TLR3-dependent type I IFN immunity (OR = 3.70[95%CI 1.3–8.2], P  = 2.1 × 10 −4 ). This enrichment was further strengthened by (1) adding the recently reported TYK2 and TLR7 COVID-19 loci, particularly under a recessive model (OR = 19.65[95%CI 2.1–2635.4], P  = 3.4 × 10 −3 ), and (2) considering as pLOF branchpoint variants with potentially strong impacts on splicing among the 15 loci (OR = 4.40[9%CI 2.3–8.4], P  = 7.7 × 10 −8 ). Finally, the patients with pLOF/bLOF variants at these 15 loci were significantly younger (mean age [SD] = 43.3 [20.3] years) than the other patients (56.0 [17.3] years; P  = 1.68 × 10 −5 ). Conclusions Rare variants of TLR3- and TLR7-dependent type I IFN immunity genes can underlie life-threatening COVID-19, particularly with recessive inheritance, in patients under 60 years old.
    Type of Medium: Online Resource
    ISSN: 1756-994X
    URL: Article
    DOI: 10.1186/s13073-023-01173-8
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2484394-5
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  • 6
    Online Resource
    Online Resource
    GRAVITY chromatic imaging of η Car’s core : Milliarcsecond resolution imaging of the wind-wind collision zone (Br γ , He I)
    EDP Sciences ; 2018
    In:  Astronomy & Astrophysics Vol. 618 ( 2018-10), p. A125-
    Details
    In: Astronomy & Astrophysics, EDP Sciences, Vol. 618 ( 2018-10), p. A125-
    Abstract: Context . η Car is one of the most intriguing luminous blue variables in the Galaxy. Observations and models of the X-ray, ultraviolet, optical, and infrared emission suggest a central binary in a highly eccentric orbit with a 5.54 yr period residing in its core. 2D and 3D radiative transfer and hydrodynamic simulations predict a primary with a dense and slow stellar wind that interacts with the faster and lower density wind of the secondary. The wind-wind collision scenario suggests that the secondary’s wind penetrates the primary’s wind creating a low-density cavity in it, with dense walls where the two winds interact. However, the morphology of the cavity and its physical properties are not yet fully constrained. Aims . We aim to trace the inner ∼5–50 au structure of η Car’s wind-wind interaction, as seen through Br γ and, for the first time, through the He  I 2s-2p line. Methods . We have used spectro-interferometric observations with the K -band beam-combiner GRAVITY at the VLTI. The analyses of the data include (i) parametrical model-fitting to the interferometric observables, (ii) a CMFGEN model of the source’s spectrum, and (iii) interferometric image reconstruction. Results . Our geometrical modeling of the continuum data allows us to estimate its FWHM angular size close to 2 mas and an elongation ratio ϵ = 1.06 ± 0.05 over a PA = 130° ± 20°. Our CMFGEN modeling of the spectrum helped us to confirm that the role of the secondary should be taken into account to properly reproduce the observed Br γ and He  I lines. Chromatic images across the Br γ line reveal a southeast arc-like feature, possibly associated to the hot post-shocked winds flowing along the cavity wall. The images of the He  I 2s-2p line served to constrain the 20 mas (∼50 au) structure of the line-emitting region. The observed morphology of He  I suggests that the secondary is responsible for the ionized material that produces the line profile. Both the Br γ and the He  I 2s-2p maps are consistent with previous hydrodynamical models of the colliding wind scenario. Future dedicated simulations together with an extensive interferometric campaign are necessary to refine our constraints on the wind and stellar parameters of the binary, which finally will help us predict the evolutionary path of η Car.
    Type of Medium: Online Resource
    ISSN: 0004-6361 , 1432-0746
    URL: Article
    DOI: 10.1051/0004-6361/201832977
    RVK:
    UA 1000
    RVK:
    US 1090
    Language: English
    Publisher: EDP Sciences
    Publication Date: 2018
    detail.hit.zdb_id: 1458466-9
    SSG: 16,12
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  • 7
    Online Resource
    Online Resource
    Direct discovery of the inner exoplanet in the HD 206893 system : Evidence for deuterium burning in a planetary-mass companion
    EDP Sciences ; 2023
    In:  Astronomy & Astrophysics Vol. 671 ( 2023-03), p. L5-
    Details
    In: Astronomy & Astrophysics, EDP Sciences, Vol. 671 ( 2023-03), p. L5-
    Abstract: Aims. HD 206893 is a nearby debris disk star that hosts a previously identified brown dwarf companion with an orbital separation of ∼10 au. Long-term precise radial velocity (RV) monitoring, as well as anomalies in the system proper motion, has suggested the presence of an additional, inner companion in the system. Methods. Using information from ongoing precision RV measurements with the HARPS spectrograph, as well as Gaia host star astrometry, we have undertaken a multi-epoch search for the purported additional planet using the VLTI/GRAVITY instrument. Results. We report a high-significance detection over three epochs of the companion HD 206893c, which shows clear evidence for Keplerian orbital motion. Our astrometry with ∼50−100 μarcsec precision afforded by GRAVITY allows us to derive a dynamical mass of 12.7$ ^{+1.2}_{-1.0} $ M Jup and an orbital separation of 3.53$ ^{+0.08}_{-0.06} $ au for HD 206893c. Our fits to the orbits of both companions in the system use both Gaia astrometry and RVs to also provide a precise dynamical estimate of the previously uncertain mass of the B component, and therefore allow us to derive an age of 155 ± 15 Myr for the system. We find that theoretical atmospheric and evolutionary models that incorporate deuterium burning for HD 206893c, parameterized by cloudy atmosphere models as well as a “hybrid sequence” (encompassing a transition from cloudy to cloud-free), provide a good simultaneous fit to the luminosity of both HD 206893B and c. Thus, accounting for both deuterium burning and clouds is crucial to understanding the luminosity evolution of HD 206893c. Conclusions. In addition to using long-term RV information, this effort is an early example of a direct imaging discovery of a bona fide exoplanet that was guided in part by Gaia astrometry. Utilizing Gaia astrometry is expected to be one of the primary techniques going forward for identifying and characterizing additional directly imaged planets. In addition, HD 206893c is an example of an object narrowly straddling the deuterium-burning limit but unambiguously undergoing deuterium burning. Additional discoveries like this may therefore help clarify the discrimination between a brown dwarf and an extrasolar planet. Lastly, this discovery is another example of the power of optical interferometry to directly detect and characterize extrasolar planets where they form, at ice-line orbital separations of 2−4 au.
    Type of Medium: Online Resource
    ISSN: 0004-6361 , 1432-0746
    URL: Article
    DOI: 10.1051/0004-6361/202244727
    RVK:
    UA 1000
    RVK:
    US 1090
    Language: English
    Publisher: EDP Sciences
    Publication Date: 2023
    detail.hit.zdb_id: 1458466-9
    SSG: 16,12
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  • 8
    Online Resource
    Online Resource
    Accretion-ejection morphology of the microquasar SS 433 resolved at sub-au scale
    EDP Sciences ; 2017
    In:  Astronomy & Astrophysics Vol. 602 ( 2017-6), p. L11-
    Details
    In: Astronomy & Astrophysics, EDP Sciences, Vol. 602 ( 2017-6), p. L11-
    Abstract: We present the first optical observation of the microquasar SS 433 at sub-milliarcsecond (mas) scale obtained with the GRAVITY instrument on the Very Large Telescope interferometer (VLTI). The 3.5-h exposure reveals a rich K -band spectrum dominated by hydrogen Br γ and He  i lines, as well as (red-shifted)emission lines coming from the jets. The K -band-continuum-emitting region is dominated by a marginally resolved point source ( 〈 1 mas) embedded inside a diffuse background accounting for 10% of the total flux. The jet line positions agree well with the ones expected from the jet kinematic model, an interpretation also supported by the consistent sign (i.e., negative/positive for the receding/approaching jet component) of the phase shifts observed in the lines. The significant visibility drop across the jet lines, together with the small and nearly identical phases for all baselines, point toward a jet that is offset by less than 0.5 mas from the continuum source and resolved in the direction of propagation, with a typical size of 2 mas. The jet position angle of ~80° is consistent with the expected one at the observation date. Jet emission so close to the central binary system would suggest that line locking, if relevant to explain the amplitude and stability of the 0.26 c jet velocity, operates on elements heavier than hydrogen. The Br γ profile is broad and double peaked. It is better resolved than the continuum and the change of the phase signal sign across the line on all baselines suggests an East-West-oriented geometry similar to the jet direction and supporting a (polar) disk wind origin.
    Type of Medium: Online Resource
    ISSN: 0004-6361 , 1432-0746
    URL: Article
    DOI: 10.1051/0004-6361/201731038
    RVK:
    UA 1000
    RVK:
    US 1090
    Language: English
    Publisher: EDP Sciences
    Publication Date: 2017
    detail.hit.zdb_id: 1458466-9
    SSG: 16,12
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  • 9
    Online Resource
    Online Resource
    First light for GRAVITY: Phase referencing optical interferometry for the Very Large Telescope Interferometer
    EDP Sciences ; 2017
    In:  Astronomy & Astrophysics Vol. 602 ( 2017-6), p. A94-
    Details
    In: Astronomy & Astrophysics, EDP Sciences, Vol. 602 ( 2017-6), p. A94-
    Abstract: GRAVITY is a new instrument to coherently combine the light of the European Southern Observatory Very Large Telescope Interferometer to form a telescope with an equivalent 130 m diameter angular resolution and a collecting area of 200 m 2 . The instrument comprises fiber fed integrated optics beam combination, high resolution spectroscopy, built-in beam analysis and control, near-infrared wavefront sensing, phase-tracking, dual-beam operation, and laser metrology. GRAVITY opens up to optical/infrared interferometry the techniques of phase referenced imaging and narrow angle astrometry, in many aspects following the concepts of radio interferometry. This article gives an overview of GRAVITY and reports on the performance and the first astronomical observations during commissioning in 2015/16. We demonstrate phase-tracking on stars as faint as m K ≈ 10 mag, phase-referenced interferometry of objects fainter than m K ≈ 15 mag with a limiting magnitude of m K ≈ 17 mag, minute long coherent integrations, a visibility accuracy of better than 0.25%, and spectro-differential phase and closure phase accuracy better than 0.5°, corresponding to a differential astrometric precision of better than ten microarcseconds ( μ as). The dual-beam astrometry, measuring the phase difference of two objects with laser metrology, is still under commissioning. First observations show residuals as low as 50 μ as when following objects over several months. We illustrate the instrument performance with the observations of archetypical objects for the different instrument modes. Examples include the  Galactic center supermassive black hole and its fast orbiting star S2 for phase referenced dual-beam observations and infrared wavefront sensing, the high mass X-ray binary BP Cru and the active galactic nucleus of PDS 456 for a few μ as spectro-differential astrometry, the T Tauri star S CrA for a spectro-differential visibility analysis, ξ  Tel and 24 Cap for high accuracy visibility observations, and η Car for interferometric imaging with GRAVITY.
    Type of Medium: Online Resource
    ISSN: 0004-6361 , 1432-0746
    URL: Article
    DOI: 10.1051/0004-6361/201730838
    RVK:
    UA 1000
    RVK:
    US 1090
    Language: English
    Publisher: EDP Sciences
    Publication Date: 2017
    detail.hit.zdb_id: 1458466-9
    SSG: 16,12
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  • 10
    Online Resource
    Online Resource
    Community-acquired pneumonia in the emergency department: an algorithm to facilitate diagnosis and guide chest CT scan indication
    Elsevier BV ; 2020
    In:  Clinical Microbiology and Infection Vol. 26, No. 3 ( 2020-03), p. 382.e1-382.e7
    Details
    In: Clinical Microbiology and Infection, Elsevier BV, Vol. 26, No. 3 ( 2020-03), p. 382.e1-382.e7
    Type of Medium: Online Resource
    ISSN: 1198-743X
    URL: Article
    DOI: 10.1016/j.cmi.2019.06.026
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2020
    detail.hit.zdb_id: 2020034-1
    SSG: 12
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