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  • 1
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    MON-113 The Effect of Body Mass Index on the Peak Growth Hormone Level After Growth Hormone Stimulation Test in Children with Short Stature
    The Endocrine Society ; 2020
    In:  Journal of the Endocrine Society Vol. 4, No. Supplement_1 ( 2020-05-08)
    Details
    In: Journal of the Endocrine Society, The Endocrine Society, Vol. 4, No. Supplement_1 ( 2020-05-08)
    Abstract: Objective: The aim of this study is to evaluate the effect of body mass index (BMI) on peak growth hormone (GH) response after GH stimulation test in children with short stature. Methods: Data was obtained from retrospective review of medical records who visited the pediatric endocrinology at St. Vincent hospital of catholic university for short stature from January 2010 to June 2019. We studied 115 children (aged 3-17 years old) whose height was less than 3percentile for one’s age and sex and who underwent GH stimulation test {GH deficiency (GHD) = 47, Idiopathic short stature (ISS) = 68)}. Peak GH response was stimulated by dopamine (n=111), clonidine (n=7), glucagon (n=19), insulin (n=56) and arginine (n=32). Birth weight, parental height, chronologic age, bone age, height SDS (standard deviation score), weight SDS, BMI SDS hemoglobin, fT4, T3 TSH, cortisol, ACTH, GH, IGF-1 SDS, IGF-BP3 SDS and peak stimulated GH were analyzed. Results: In the characteristics of subject, weight SDS and BMI SDS in GHD group were increased than ISS group (p & lt;0.000, p=0.000). Free T4 was decreased in GHD group than ISS group (p=0.012). In total group, BMI SDS was associated negatively with peak GH level stimulated by dopamine (r=-0.419, p & lt;0.000), insulin (r=-0.271, p=0.044) and arginine (r=-0.368, p=0.038), but did not showed correlation with peak GH level stimulated by glucagon. In GHD group, BMI SDS showed negative correlation with peak GH level using dopamine (r=-0.356, p=0.015) and arginine (r=-0.509, p=0.022). In ISS group, BMI SDS was correlated negatively with peak GH using dopamine (r=-0.330, p=0.007). In multivariate regression analysis of GHD group, weight SDS and BMI SDS were the only two significant predictors of peak GH response in stimulation test stimulated by dopamine (ß=-0.576, p=0.015) and arginine (ß=-0.097, p=0.022). In ISS group, only mother’s height (ß=0.474, p=0.000) and TSH (ß=-2.251, p & lt;0.000) were demonstrated statistically significant predictors of peak GH stimulated by dopamine in multivariate regression analysis. In case of using insulin as a stimulant in ISS group, there is nothing which has statistical significance as a predictor of peak GH response in multivariate regression analysis. Conclusion: BMI was associated negatively with peak GH response after GH stimulation test in children with short stature, especially in GHD group.
    Type of Medium: Online Resource
    ISSN: 2472-1972
    URL: Article
    DOI: 10.1210/jendso/bvaa046.1014
    Language: English
    Publisher: The Endocrine Society
    Publication Date: 2020
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  • 2
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    SUN-724 Associations of GPR174 and ITM2A Genes on X Chromosome with Early Onset Autoimmune Thyroid Disease in Korean
    The Endocrine Society ; 2020
    In:  Journal of the Endocrine Society Vol. 4, No. Supplement_1 ( 2020-05-08)
    Details
    In: Journal of the Endocrine Society, The Endocrine Society, Vol. 4, No. Supplement_1 ( 2020-05-08)
    Abstract: Background: Autoimmune thyroid diseases (AITDs) are female predominant and the biology of sexual dimorphism is not clearly understood. Recently, GPR174 and ITM2A on X chromosome have been newly suggested as autoimmune thyroid disease susceptible loci. Methods: Fourteen single nucleotide polymorphisms in immune related genes on X chromosome were analyzed in 108 Korean children (girls =90, boys =18) with AITD [Hashimoto disease (HD) = 40, Graves′ disease (GD) = 68, thyroid-associated ophthalmopathy (TAO) = 37, and non-TAO =60] with gender ratio matched normal control 106 controls (female = 43, male = 63). Results: In AITD, the frequencies of GPR174 rs3810711 T allele (OR=6.0, cP =0.000), GRP174 rs3827440 T allele (OR=6.0, cP =0.000), ITM2A-GPR174 rs5912838 A allele (OR=2.7, cP =0.001) were increased and of GPR174 rs3810711 CC genotype (OR=0.2, cP =0.000), GRP174 rs3827440 CC genotype (OR=0.2, cP =0.000), ITM2A-GPR174 rs5912838 CC genotype (OR=0.4, cP =0.000)were lower than controls. In GD, the frequencies of GPR174 rs3810711 T allele (OR=8.4, cP =0.000), GRP174 rs3827440 T allele (OR=8.4, cP =0.000), ITM2A-GPR174 rs5912838 A allele (OR=3.3, cP =0.000) were increased and GPR174 rs3810711 CC genotype (OR=0.1, cP =0.000), C allele (OR=0.5, cP =0.044), GRP174 rs3827440 CC genotype (OR=0.2, cP =0.000), C allele (OR=0.5, cP =0.044), ITM2A-GPR174 rs5912838 CC genotype (OR=0.4, cP =0.000) were lower than controls. In HD, the frequencies of GPR174 rs3810711 T allele (OR=3.9, cP =0.003), GRP174 rs3827440 T allele(OR=3.9, cP =0.003) were increased and GPR174 rs3810711 CC genotype (OR=0.3, cP =0.004), rs3827440 CC genotype (OR=3.9, cP =0.003) were lower than controls. In thyroid-associated ophthalmopathy, the frequencies of GPR174 rs3810711 T allele (OR=7.9, cP =0.000), GRP174 rs3827440 T allele (OR=7.9, cP =0.000), ITM2A-GPR174 rs5912838 A allele (OR=3.1, cP =0.001) were increased and of GPR174 rs3810711 CC genotype (OR=0.1, cP =0.000), GRP174 rs3827440 CC genotype (OR=0.1, cP =0.000), ITM2A-GPR174 rs5912838 CC genotype (OR=0.3, cP =0.014)were lower than controls. Conclusions. Our results suggest that polymorphisms of GPR174 and ITM2A genes on X chromosome might contribute to the pathogenesis of AITD.
    Type of Medium: Online Resource
    ISSN: 2472-1972
    URL: Article
    DOI: 10.1210/jendso/bvaa046.1016
    Language: English
    Publisher: The Endocrine Society
    Publication Date: 2020
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  • 3
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    Effects of ozone and aerosol on surface UV radiation variability
    Elsevier BV ; 2013
    In:  Journal of Photochemistry and Photobiology B: Biology Vol. 119 ( 2013-2), p. 46-51
    Details
    In: Journal of Photochemistry and Photobiology B: Biology, Elsevier BV, Vol. 119 ( 2013-2), p. 46-51
    Type of Medium: Online Resource
    ISSN: 1011-1344
    URL: Article
    DOI: 10.1016/j.jphotobiol.2012.11.007
    RVK:
    WA 15000
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2013
    detail.hit.zdb_id: 1482691-4
    SSG: 12
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  • 4
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    Impact of Male Hypogonadism on Bone Mineral Density in Childhood Hemato-Oncologic Disease
    The Endocrine Society ; 2021
    In:  Journal of the Endocrine Society Vol. 5, No. Supplement_1 ( 2021-05-03), p. A718-A718
    Details
    In: Journal of the Endocrine Society, The Endocrine Society, Vol. 5, No. Supplement_1 ( 2021-05-03), p. A718-A718
    Abstract: Introduction: Patients with childhood hemato-oncologic diseases have many medical problems, not only due to disease itself, but also adverse effects of specific treatment that patients had. Osteoporosis, one of the most common side effects of the treatment, decreases quality of life when the disease progresses. Our study investigated the impact of male hypogonadism on secondary osteoporosis in childhood hemato-oncologic patients, using association between male sex hormone and bone mineral density (BMD) measured by dual energy X-ray absorptiometry (DXA). Methods: This study collected BMD score (T-score) of 52 male subjects who were diagnosed with hemato-oncologic diseases in the past (average age of 22.3 years at DXA examination). All subjects measured serum testosterone and we divided them into two subgroups according to gonadal status. The first group, called hypogondal group, was a group of subjects with serum testosterone level less than 3.5 ng/ml. The other group was classified into eugonadal group, with serum testosterone level equal or more than 3.5 ng/ml. Mean BMD score of spine and hip were presented and compared between the two groups. Furthermore, relativity with other risk factors for osteoporosis was calculated using multiple regression analysis. Results: Overall, spine BMD in the hypogondal group did not significantly differ from the eugonadal group. However, hip BMD was significantly lower in the hypogonadal group (mean difference; 0.8, p = 0.023). Furthermore, testosterone level itself showed linear correlation with BMD score in hip (p = 0.013). When other risk factors for osteoporosis were taken into account, hemato-oncologic patients treated with total body irradiation also had significantly lower hip BMD (p = 0.007) compared with non-irradiation group. Hypogonadism still remained a significant factor for decreased bone mineral density in hip (p = 0.022). Conclusions: Hemato-oncologic patients with hypogonadism or previously treated with total body irradiation are at increased risk of decreased bone mineral density in both hips. Hypogonadism alone remains independent risk factor for osteoporosis in hip. Attention of these male patient should be paid to prevent the incidence of secondary osteoporosis.
    Type of Medium: Online Resource
    ISSN: 2472-1972
    URL: Article
    DOI: 10.1210/jendso/bvab048.1461
    Language: English
    Publisher: The Endocrine Society
    Publication Date: 2021
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  • 5
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    MON-088 Impact of Vertebral Fracture on Auxological Profile and Insulin-Like Growth Factors of Children After Acute Lymphoblastic Leukemia Treatment
    The Endocrine Society ; 2020
    In:  Journal of the Endocrine Society Vol. 4, No. Supplement_1 ( 2020-05-08)
    Details
    In: Journal of the Endocrine Society, The Endocrine Society, Vol. 4, No. Supplement_1 ( 2020-05-08)
    Abstract: Purpose: To investigate the overall prevalence of vertebral fractures (VF) following childhood acute lymphoblastic leukemia (ALL) treatment and examine the association of VF with growth trajectory and insulin-like growth factors. Methods: Children (n=172; 59.3 % male) diagnosed with ALL at age between 2 and 18 years were assessed for VF by screening the lateral thoracolumbar spine radiographs (Genant’s semi-quantitative method) when treatment was completed (baseline). Anthropometric measurements between pre- to post-treatment period were obtained and the association of VF with insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) were examined. Results: Thirty-five children (20.3 %) had vertebral fractures at baseline. Among children with vertebral fractures, 97.1 % had either mild or moderate deformity, and the 5th lumbar vertebrae was the most frequently injured site (20.0 %). Median lumbar spine bone mineral density Z-score was -1.0 (IQR of -1.6 and -0.8) in children with VF. Baseline Z-scores for height and weight were lower in children with VF than without VF (-0.5±1.3 and 0.0±0.9, P=0.01; -0.2±1.6 and 0.3±1.1, P=0.04, respectively). Height Z-score in children with VF had greater height decline than without VF (0.5±0.6 and 0.2±0.8; P=0.02). Children with VF had lower IGF-1 and IGFBP-3 Z-score than without VF at baseline (-1.2±1.0 and 0.0±0.8, P & lt;0.01; -2.3±1.1 and -1.3±1.0, P & lt;0.01). Decrease in IGF-1 level was associated with the presence of VF (OR=0.3(95 % CI of 0.2-0.5), P & lt;0.01). Conclusion: Substantial number of children encounter VF after ALL treatment is completed and the presence of VF might be associated with compromised auxological state, prominent height decline and IGF-1 deficiency.
    Type of Medium: Online Resource
    ISSN: 2472-1972
    URL: Article
    DOI: 10.1210/jendso/bvaa046.1562
    Language: English
    Publisher: The Endocrine Society
    Publication Date: 2020
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  • 6
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    Goiter at Diagnosis Might Be Predicting Factor for Early Onset Intractable Graves’ Disease
    The Endocrine Society ; 2021
    In:  Journal of the Endocrine Society Vol. 5, No. Supplement_1 ( 2021-05-03), p. A830-A830
    Details
    In: Journal of the Endocrine Society, The Endocrine Society, Vol. 5, No. Supplement_1 ( 2021-05-03), p. A830-A830
    Abstract: Introduction: The clinical course of Graves’ disease (GD) treated with anti-thyroid drug (ATD) treatment were reviewed with the aim of establishing criteria able to predict intractable GD. Methods: The clinical course of 116 patients with GD who agreed to participate in this study between March 2009 and August 2019 in the pediatric endocrine clinic at Seoul St. Mary’s and St. Vincent’s Hospitals were reviewed. We defined an intractable as hyperthyroidism persistent over 2 years of ATD or relapsed after ATD withdrawal or had been treated ATD for at least 5 years [1-3]. Result: Of 116 patients diagnosed with GD, 37 patients (31.8%) had remission and 79 (68.2%) had intractable GD. Between intractable and remission GD group, there were no significant difference of female percentage, age at diagnosis, thyroid associated ophthalmopathy, serum levels of triiodothyronine (T3), free tetraiodothyronine (T4), Thyroid stimulating hormone (TSH) and positive rate of thyroid autoantibody (Thyroid peroxidase (TPO), Thyroglobulin (Tg), Thyroid stimulating hormone receptor (TSHR)). In intractable GD patients, the frequency of goiter at diagnosis is higher than remission group (89.9% [71/79] and 70.3% [26/37], P-value = 0.014). In correlation analysis, intractable GD showed positive correlation with goiter (R=0.247, P-value = 0.008). In multivariate logistic analyses, goiter is showed strong relationship with intractable GD (odds ratio, 3.793; 95% confidence interval, 1.367-10.524) after adjusting age and sex. Conclusion: Our study supported that goiter at initial presentation might be predicting factor for early onset intractable GD.
    Type of Medium: Online Resource
    ISSN: 2472-1972
    URL: Article
    DOI: 10.1210/jendso/bvab048.1692
    Language: English
    Publisher: The Endocrine Society
    Publication Date: 2021
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  • 7
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    Revisiting cloud overlap with a merged dataset of liquid and ice cloud extinction from CloudSat and CALIPSO
    Frontiers Media SA ; 2022
    In:  Frontiers in Remote Sensing Vol. 3 ( 2022-12-22)
    Details
    In: Frontiers in Remote Sensing, Frontiers Media SA, Vol. 3 ( 2022-12-22)
    Abstract: We update the parameterization capturing the variation of parameters that describe how cloud occurrence (layer cloud fraction) and layer cloud optical depth (COD) distributions overlap vertically. Our updated analysis is motivated by the availability of a new dataset constructed by combining two products describing the two-dimensional extinction properties of liquid and ice phase clouds (and their mixtures) according to active cloud observations by the CloudSat and CALIPSO satellites. As before, cloud occurrence overlap is modeled with the decorrelation length of an inverse exponential function describing the decay with separation distance of the relative likelihood that two cloudy layers are overlapped maximally versus randomly. Similarly, cloud optical depth distribution vertical overlap is described again with a decorrelation length that describes the assumed inverse exponential decay with separation distance of the rank correlation between cloud optical depth distribution members in two cloudy layers. We derive the climatological zonal variability of these two decorrelation lengths using 4 years of observations for scenes of ∼100 km scale length, a typical grid size of numerical models used for climate simulations. As previously, we find a strong latitudinal dependence reflecting systematic differences in dominant cloud types with latitude, but substantially different magnitudes of decorrelation length compared to the previous work. The previously used parameterization form is therefore updated with new parameters to describe the latitudinal dependence of decorrelation lengths and its seasonal shift. Similar zonal patterns of decorrelation length are found when the analysis is broken down by different cloud classes. When the revised parameterization is implemented in a cloud subcolumn generator, simulated column cloud properties compare to observations quite well, and so do their associated cloud radiative effects, but improvements over the earlier version of the parameterization are marginal.
    Type of Medium: Online Resource
    ISSN: 2673-6187
    URL: Article
    DOI: 10.3389/frsen.2022.1076471
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 3091289-1
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  • 8
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    Microcurvature Controllable MetalOrganic Framework Nanoagents Capable of Ice-Lattice Matching for Cellular Cryopreservation
    American Chemical Society (ACS) ; 2023
    In:  JACS Au Vol. 3, No. 1 ( 2023-01-23), p. 154-164
    Details
    In: JACS Au, American Chemical Society (ACS), Vol. 3, No. 1 ( 2023-01-23), p. 154-164
    Type of Medium: Online Resource
    ISSN: 2691-3704 , 2691-3704
    URL: Article
    URL: Article
    DOI: 10.1021/jacsau.2c00562
    DOI: 10.1021/jacsau.2c00562.s001
    Language: English
    Publisher: American Chemical Society (ACS)
    Publication Date: 2023
    detail.hit.zdb_id: 3049543-X
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  • 9
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    New insights about cloud vertical structure from CloudSat and CALIPSO observations
    American Geophysical Union (AGU) ; 2017
    In:  Journal of Geophysical Research: Atmospheres Vol. 122, No. 17 ( 2017-09-16), p. 9280-9300
    Details
    In: Journal of Geophysical Research: Atmospheres, American Geophysical Union (AGU), Vol. 122, No. 17 ( 2017-09-16), p. 9280-9300
    Abstract: We use observations from so‐called “active” sensors (satellite instruments emitting pulses of radiation toward Earth) in order to derive, classify, and understand how clouds are stratified vertically in the atmosphere. The stratification is important for the Earth's energy budget. We show how the various major cloud vertical structures affect the propagation of solar and thermal radiation. We also examine the composition of recurring cloud systems observed from so‐called “passive” sensors (satellite instruments receiving from the Earth naturally reflected or emitted radiation) in terms of the cloud vertical configurations they contain.
    Type of Medium: Online Resource
    ISSN: 2169-897X , 2169-8996
    URL: Issue
    URL: Article
    DOI: 10.1002/jgrd.v122.17
    DOI: 10.1002/2017JD026629
    Language: English
    Publisher: American Geophysical Union (AGU)
    Publication Date: 2017
    detail.hit.zdb_id: 710256-2
    detail.hit.zdb_id: 2016800-7
    detail.hit.zdb_id: 2969341-X
    SSG: 16,13
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  • 10
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    Radiative effects of global MODIS cloud regimes
    American Geophysical Union (AGU) ; 2016
    In:  Journal of Geophysical Research: Atmospheres Vol. 121, No. 5 ( 2016-03-16), p. 2299-2317
    Details
    In: Journal of Geophysical Research: Atmospheres, American Geophysical Union (AGU), Vol. 121, No. 5 ( 2016-03-16), p. 2299-2317
    Abstract: Cloud systems can be organized into cloud regimes The regimes can be identified from passive observations such as MODIS The regimes have very different radiative effects that can be intercompared
    Type of Medium: Online Resource
    ISSN: 2169-897X , 2169-8996
    URL: Issue
    URL: Article
    DOI: 10.1002/jgrd.v121.5
    DOI: 10.1002/2015JD024502
    Language: English
    Publisher: American Geophysical Union (AGU)
    Publication Date: 2016
    detail.hit.zdb_id: 710256-2
    detail.hit.zdb_id: 2016800-7
    detail.hit.zdb_id: 2969341-X
    SSG: 16,13
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