In:
Journal of Applied Toxicology, Wiley, Vol. 40, No. 7 ( 2020-07), p. 918-930
Abstract:
Ultrasmall superparamagnetic iron oxide nanoparticles (USPION) possess unique magnetic properties that can be exploited to design novel theranostic biomedical products; however, toxicity mechanisms of USPION are not completely elucidated. The goal of this study was to investigate cell interactions (uptake and cytotoxicity) of PVP‐coated USPION (20 nm diameter) using human coronary artery endothelial cells (HCAECs) as a vascular cell model. The results demonstrate that USPION rapidly accumulate in cells, inducing a concentration‐ and time‐dependent cytotoxicity involving apoptosis.
Type of Medium:
Online Resource
ISSN:
0260-437X
,
1099-1263
Language:
English
Publisher:
Wiley
Publication Date:
2020
detail.hit.zdb_id:
1475015-6
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