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  • 1
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    Online Resource
    Features of metabolic disorders in chromium mine workers
    Federal Scientific Center for Hygiene F.F.Erisman ; 2021
    In:  Hygiene and sanitation Vol. 100, No. 10 ( 2021-10-31), p. 1095-1102
    Details
    In: Hygiene and sanitation, Federal Scientific Center for Hygiene F.F.Erisman, Vol. 100, No. 10 ( 2021-10-31), p. 1095-1102
    Abstract: Introduction. Working conditions, clinical and laboratory status of 236 workers of a chromium mine were investigated. Materials and methods. The observation group included 162 underground employees working in conditions of the combined impact of negative occupational factors (dust, noise, vibration, tension and severity there, cooling microclimate) - class 3.3-3.4. The comparison group included 74 mine employees working in acceptable working conditions - class 2. Results. In the observation group, the pathology of the cardiovascular and endocrine system (ICD-10: I00-I99, E00-E07) was detected 2.8-3.3 times more often (p = 0.001-0.02), the relative risk of disease formation was 2.7-3.2 times higher than in the comparison group (RR = 2.7-3.2; DI = 1.44-9.2; p = 0.001-0.02). Under the conditions of the combined effect of negative production factors, as features of metabolic disorders, it was noted that the most unfavourable - abdominal form of obesity was diagnosed 1.4 times more often (42.0%, p = 0.013), the atherogenic index was 1.2 times higher, and the level HDL is 1.2 times lower than in the comparison group (p = 0.017-0.047); “Metabolic indices” - lipid accumulation coefficient (LAP) and visceral obesity index (VAI) were 1.2-1.4 times higher than the values in the comparison group (p = 0.001-0.048). Conclusions. To implement a complex of medical and preventive measures aimed at increasing life expectancy and working longevity, early prevention of CVD, including among those working in the extraction of chrome ore, it is advisable to consider the introduction of the calculation of early markers of metabolic disorders - VAI and LAP indices in the medical examination programs.
    Type of Medium: Online Resource
    ISSN: 2412-0650 , 0016-9900
    URL: Issue
    URL: Article
    DOI: 10.47470/0016-9900-2021-100-10
    DOI: 10.47470/0016-9900-2021-100-10-1095-1102
    Language: Unknown
    Publisher: Federal Scientific Center for Hygiene F.F.Erisman
    Publication Date: 2021
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  • 2
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    Regional peculiarities of the epidemiological process caused by SARS-COV-2 (COVID-19), compensation for the impact of modifying factors of non-infectious genesis
    Federal Scientific Center for Hygiene F.F.Erisman ; 2022
    In:  Hygiene and sanitation Vol. 101, No. 6 ( 2022-06-30), p. 701-708
    Details
    In: Hygiene and sanitation, Federal Scientific Center for Hygiene F.F.Erisman, Vol. 101, No. 6 ( 2022-06-30), p. 701-708
    Abstract: Introduction. The development of SARS-COV-2 (COVID-19) pandemic creates certain analytical challenges with respect to both examining the spread of the disease itself and investigating reasons and regularities in the epidemic propagation under different conditions. This article dwells on the least examined issue related to the necessity to establish peculiarities and reasons for occurring differences in the coronavirus infection spread in RF regions with different socioeconomic and social-hygienic status. This is necessary for substantiating relevant actions, which are to compensate for preventable modifying influence exerted by environmental factors and lifestyle-related ones. Materials and methods. The study involved analyzing regularities in regional differentiation of parameters in a classic SIR model describing the epidemic process in RF regions. We analyzed data on more than two hundred fifty various indicators describing levels of infection, vaccination, hospital admission and mortality among population collected in 85 RF regions in 2020-2021. All the data were taken as average values over a week. Results. We assessed parameters of mathematical models for RF regions. The assessments gave grounds for analyzing peculiar development of the epidemic process and for detecting basic regularities in the territorial distribution of parameters describing rates of infection, recovery and mortality rate and the basic reproductive number for SARS-COV-2 virus. Limitations. The results are limited by data aggregation performed only at a regional level and a simplified model of the developing epidemic process applied in the present study. Another limitation is insufficient coverage of environmental factors reflecting peculiarities in the infection spread. The latter is considered a promising trend in future research. Conclusion. The study made it possible to trace basic peculiarities and regularities in the spread of the disease and to spot out regions where the epidemic process was the most acute and accompanied with the highest burdens on regional social security services. These trends and regularities indicate to the occurring regional differentiation detected at various stages in the development of epidemic process of the new coronavirus infection (COVID-19) spread due to the Delta strain caused by complex interactions and influence exerted by modifying factors creating a certain multi-level and multi-component structure.
    Type of Medium: Online Resource
    ISSN: 2412-0650 , 0016-9900
    URL: Issue
    URL: Article
    DOI: 10.47470/0016-9900-2022-101-6
    DOI: 10.47470/0016-9900-2022-101-6-701-708
    Language: Unknown
    Publisher: Federal Scientific Center for Hygiene F.F.Erisman
    Publication Date: 2022
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  • 3
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    Modifying impact of environmental factors on the course of an epidemic process
    Federal Scientific Center for Hygiene F.F.Erisman ; 2022
    In:  Hygiene and sanitation Vol. 101, No. 11 ( 2022-11-30), p. 1274-1282
    Details
    In: Hygiene and sanitation, Federal Scientific Center for Hygiene F.F.Erisman, Vol. 101, No. 11 ( 2022-11-30), p. 1274-1282
    Abstract: Introduction. It is necessary to establish peculiarities and regularities of COVID-19 infection; this task requires further research on how to formalize and build spatial-temporal models of the infection spread. This article focuses on determining non-infectious factors that can modify the epidemic process caused by the COVID-19 coronavirus for further substantiation of integrated solutions that are necessary to ensure sanitary-epidemiological welfare of the RF population. Materials and methods. Our study involved analyzing regularities of regional differentiation in parameters introduced into mathematical models. These models described how the epidemic process developed in RF regions depending on modifying non-infectious factors identified by modelling the dynamics of spread of SARS-CoV-2 delta strain. These modifying factors included anti-epidemic activities; sanitary-epidemiological, sociodemographic, and economic conditions in a region; weather and climate; public healthcare systems and people’s lifestyles in RF regions over 2020-2021. The dynamics of the epidemic process was modelled by using the conventional SIR-model. Relationships between parameters introduced into the model of the epidemic process and modifying regional conditions were examined by using correlation-regression analysis. Results. The modelling made it possible to identify priority risk factors that modified COVID-19 spread authentically (p 〈 0.05) and explained regional differences in intensity of contagion, recovery and lethality. We established that population coverage with vaccination, especially among people aged 31-40 years, had the greatest authentic positive influence on the decline of reproduction index (R0) of the virus (r=-0.37). An increase in monthly average temperatures in autumn and winter as well as over a year made for people moving faster from the susceptible to infected category (r=0.21-0.22). Growing sun insolation over a year, especially in summer, resulted in slower movement of susceptible people into the infected category (r=-0.02-(-0.23)). Next, several sanitary-epidemiological indicators authentically made the infection spread faster; they were improper working conditions (not conforming to the safety standards as per physical indicators) and ambient air quality in settlement not corresponding to the hygienic standards as per chemical indicators and noise (r=0.29-0.24). Recovery took longer in regions where alcohol consumption was comparatively higher (r=-0.32). Limitations. The limitations of the study include modelling the epidemic process using the standard SIR model; limited set of indicators and period of analysis. Conclusions. The existing regional differentiation in development of specific stages in the epidemic process related to the COVID-19 delta strain occurs due to complex interactions and influence exerted by modifying factors that create a certain multi-level and multi-component system. This system is able to transform the epidemic process either potentiating it or slowing it down.
    Type of Medium: Online Resource
    ISSN: 2412-0650 , 0016-9900
    URL: Issue
    URL: Article
    DOI: 10.47470/0016-9900-2022-101-11
    DOI: 10.47470/0016-9900-2022-101-11-1274-1282
    Language: Unknown
    Publisher: Federal Scientific Center for Hygiene F.F.Erisman
    Publication Date: 2022
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  • 4
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    On assessment of Rospotrebnadzor surveillance and control activities efficiency and effectiveness aimed at preserving the health of workers
    FSBI Research Institute of Occupational Health RAMS ; 2021
    In:  Russian Journal of Occupational Health and Industrial Ecology Vol. 61, No. 12 ( 2021-12-25), p. 807-814
    Details
    In: Russian Journal of Occupational Health and Industrial Ecology, FSBI Research Institute of Occupational Health RAMS, Vol. 61, No. 12 ( 2021-12-25), p. 807-814
    Abstract: In order to achieve the national development purposes of the Russian Federation for the protection and improvement of public health as declared in the strategic documents, under conditions of limited budgetary resources it is relevant to improve the efficiency and effectiveness of public administration, including that of organizations carrying out control and supervision functions. The aim of the study was to develop methods for assessing the efficiency and effectiveness of Rospotrebnadzor control and supervision activities and the interpretation of the assessment results, as well as to test the proposed approaches in the analysis of the regional distribution of efficiency and effectiveness indicators in the Russian Federation Regions. Using methods of mathematical statistics, the cause-effect relationships between medical and demographic indicators, environmental quality indicators and Rospotrebnadzor activities in the triple system "Rospotrebnadzor activities - environmental quality - public health" were established and parameterized. The actual and prevented health and demographic (morbidity and mortality) economic losses associated with the negative impact of environmental factors have been assessed as a result of control and supervision activities. The calculation of indicative indicators of effectiveness and efficiency of control and supervision activities of Rospotrebnadzor in the Russian Federation Regions and the Russian Federation in general, has been carried out. The analysis of the regional distribution of the indicator of the effectiveness of the control and supervision activities of Rospotrebnadzor is performed. Using the method of k-means cluster analysis, typology of the Russian Federation Regions was carried out according to a set of indicators characterizing the performance of Rospotrebnadzor, the level of macroeconomic development of the region and the amount of funds allocated for control and surveillance activities to ensure sanitary and epidemiological welfare in the Russian Federation Regions. The results obtained from the analysis of the regional distribution of indicative indicators and the typology of the Russian Federation Regions (compared with the national average) can be used as a reference point for the Russian Federation Regions when assessing management reserves and developing programmes of measures to reduce risks to public health.
    Type of Medium: Online Resource
    ISSN: 2618-8945 , 1026-9428
    URL: Issue
    URL: Article
    DOI: 10.31089/1026-9428-2021-61-12
    DOI: 10.31089/1026-9428-2021-61-12-807-814
    Language: Unknown
    Publisher: FSBI Research Institute of Occupational Health RAMS
    Publication Date: 2021
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  • 5
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    Assessment of disorders of carbohydrate and fat metabolism in children under conditions of oral exposure to organochlorine compounds
    Federal Scientific Center for Hygiene F.F.Erisman ; 2020
    In:  Hygiene and sanitation Vol. 99, No. 11 ( 2020-12-22), p. 1263-1270
    Details
    In: Hygiene and sanitation, Federal Scientific Center for Hygiene F.F.Erisman, Vol. 99, No. 11 ( 2020-12-22), p. 1263-1270
    Abstract: Introduction. The authors performed a hygienic and epidemiological study of the Perm Territory areas with unfavorable sanitary and hygienic indices. Material and methods. The study involved 7,775 children aged from 4 to 14 years (9.2 ± 3.7 years) living in territories using sodium hypochlorite or liquid chlorine (Perm, Krasnokamsky, Nytvensky districts). The comparison group consisted of 425 children (average age 9.3 ± 2.5 years) consuming drinking water that complies with hygienic standards (Sivinsky, Karagai districts). Results. Identified areas with low quality of drinking water supply due to the content of organochlorine compounds (OCS) appeared to have an increased prevalence of obesity, diabetes, ischemic, and hypertensive disease. The authors developed and tested the critical assessment of the risk of formation disorders of fat and carbohydrate metabolism in children consuming drinking water with a high content of organochlorine compounds. Under conditions of oral exposure to OCS (0.43-0.64 mg / l, more than 3 MPC), the index of the risk of impaired fat and carbohydrate metabolism in children (IPI 0.55) was 1.3 times higher than the corresponding levels in the territory of comparison (IPI 0,42). Conclusion. The main markers for the indices of the negative impact of HOS (primarily chloroform) include an increase in the blood level of triglycerides (PS 0.41), LDL (PS 0.25) and a decrease in HDL (PS 0.18), exceeding 1, 2-1.6 times the territory of comparison.
    Type of Medium: Online Resource
    ISSN: 2412-0650 , 0016-9900
    URL: Issue
    URL: Article
    DOI: 10.47470/0016-9900-2020-99-11
    DOI: 10.47470/0016-9900-2020-99-11-1263-1270
    Language: Unknown
    Publisher: Federal Scientific Center for Hygiene F.F.Erisman
    Publication Date: 2020
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  • 6
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    Online Resource
    Health risks analysis and complex procedure for estimating the efficiency of targeted activities performed within regional public healthcare systems and aimed at reducing mortality among the population caused by cardiovascular diseases and oncologic diseases
    Federal Scientific Center for Hygiene F.F.Erisman ; 2021
    In:  HEALTH CARE OF THE RUSSIAN FEDERATION Vol. 65, No. 4 ( 2021-09-07), p. 302-309
    Details
    In: HEALTH CARE OF THE RUSSIAN FEDERATION, Federal Scientific Center for Hygiene F.F.Erisman, Vol. 65, No. 4 ( 2021-09-07), p. 302-309
    Abstract: Introduction. Preservation and growth of the country population is the top national priority in the Russian Federation. A contemporary approach focuses on several especially urgent demographic issues that can be resolved, among other things, due to public healthcare systems becoming more efficient. The present research work is vital due to the necessity to achieve target medical and demographic parameters fixed in the national and federal projects and regional programs. These parameters include life expectancy and mortality caused by cardiovascular and oncologic diseases. The goal of this work is a development of new approaches for the complex evaluation of potential management reserves of health population indicators and the prognosis of efficiency of targeted activities performed within public healthcare systems and aimed at increasing life expectancy through reducing mortality among the population caused by cardiovascular diseases and oncologic diseases. Material and methods. The work dwells on solving a “direct” task in the “medical activities - morbidity - mortality” triple analysis system; the solution involves predicting changes in morbidity and mortality under preset, planned, or scenario changes in parameters related to the public healthcare system. We modelled cause-and-effect relations in the above system, applying mathematical statistics techniques (correlation-regression analysis and factor analysis) with the consequent medical expertise of obtained results. Results. These procedures allow assessing health losses and spot out priorities in activities performed within the public healthcare system as well as ranking managerial decisions, already taken or only planned, as per their efficiency, taking into account territories; sex and age structure of the population; diseases, their subclasses and gravity; specific activities performed within the public healthcare system (prevention, diagnostics, or treatment). We should stress that the most significant potential management reserves of reducing mortality are achieved on territories with maximum mortality levels due to reserves for the reduction in it; these reserves are manageable due to prevention and early diagnostics. Conclusion. Research techniques and results described in the present work can be used in practice to achieve target parameters fixed by national and regional priorities and to select an optimal set of activities aimed at reducing mortality among the population.
    Type of Medium: Online Resource
    ISSN: 2412-0723 , 0044-197X
    URL: Issue
    URL: Article
    DOI: 10.47470/0044-197X-2021-65-4
    DOI: 10.47470/0044-197X-2021-65-4-302-309
    Language: Unknown
    Publisher: Federal Scientific Center for Hygiene F.F.Erisman
    Publication Date: 2021
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  • 7
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    Complex evaluation of health state of population residing under combined exposure to noise and chemical risk factors caused by activities of major airport hub
    FSBI Research Institute of Occupational Health RAMS ; 2019
    In:  Occupational Health and Industrial Ecology , No. 10 ( 2019-02-18), p. 12-16
    Details
    In: Occupational Health and Industrial Ecology, FSBI Research Institute of Occupational Health RAMS, , No. 10 ( 2019-02-18), p. 12-16
    Abstract: Complex evaluation covered health state of population residing under combined exposure to physical (noise) and chemical (manganese, formaldehyde, phenol, benzene) risk factors caused by airport activities. Findings are unacceptable chronic risks expressed through risk index for development of nervous system diseases (HI=9.45–51.75), respiratory disorders (HQ=2,62–6,95) and immune system ailments (HQ=1,75–4,23). In children, functional disorders of nervous system (parasympathetic type vegetative dystonia) and respiratory organs (chronic disorders of upper respiratory tract) are diagnosed 1,5–1,8 times higher than those in the reference group; over 5% of children aged 4–7 years demonstrate bilateral conductive deafness. Reliable cause-effect relationships were revealed between functional nervous system disorders (parasympathetic type vegetative dystonia, astheno-neurotic syndrome, vascular cephalgia, sleep disorders) and increased serum level of manganese and benzene (proportion of explained dispersion, R 2 =0,55–0,87, 26,44≤F≥389,54), between respiratory diseases (chronic rhinitis, chronic pharyngitis) and increased serum level of formaldehyde (R 2 =0,73–0,91; 350,8≤F≥778,3), with high statistic significance (p 〈 0,0001). For sanitary epidemiologic examination purposes, case-based reasoning for relationships of children health disorders, management decisions, the authors suggested and justified a list of parameters for negative combined impact of risk factors caused by airport hub.
    Type of Medium: Online Resource
    ISSN: 2618-8945 , 1026-9428
    URL: Issue
    URL: Article
    DOI: 10.31089/1026-9428-2018-10
    DOI: 10.31089/1026-9428-2018-10-12-16
    Language: Unknown
    Publisher: FSBI Research Institute of Occupational Health RAMS
    Publication Date: 2019
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  • 8
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    Measurement technique and results of evaluating influence of heating microclimate on skin surface temperature in workers engaged into oil thermal mining
    FSBI Research Institute of Occupational Health RAMS ; 2019
    In:  Occupational Health and Industrial Ecology , No. 10 ( 2019-02-18), p. 49-53
    Details
    In: Occupational Health and Industrial Ecology, FSBI Research Institute of Occupational Health RAMS, , No. 10 ( 2019-02-18), p. 49-53
    Abstract: The study was aimed to refine a method evaluating level and dynamics of skin surface temperature as an indicator of heat state in a worker exposed to intermittent influence of workplace ambient high temperatures during a working shift. The measurement technique was automated continuous detection with registration of parameters every 5 seconds and the data backup to memory card. Findings are that actual scenarios of heat load on the workers significantly differ from the calculated ones. Mathematic models of relationships between air temperature and skin temperature were obtained and helped to play various scenarios of the workers’ presence in “heat” zones and evaluate them according to criteria of weighted average and maximal skin temperature. Results are thatoCcupational conditions of workers engaged into underground oil thermal mining necessitate specification and implementation of preventive measures and improved regulatory support, concerning creation of safe microclimate parameters.
    Type of Medium: Online Resource
    ISSN: 2618-8945 , 1026-9428
    URL: Issue
    URL: Article
    DOI: 10.31089/1026-9428-2018-10
    DOI: 10.31089/1026-9428-2018-10-49-53
    Language: Unknown
    Publisher: FSBI Research Institute of Occupational Health RAMS
    Publication Date: 2019
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  • 9
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    Hygienic analysis of violations of sanitary and epidemiological requirements for working conditions in the field of "Mining" before and after the introduction of a risk-oriented model of control and supervisory activities (on the example of the Perm Region)
    FSBI Research Institute of Occupational Health RAMS ; 2021
    In:  Russian Journal of Occupational Health and Industrial Ecology Vol. 61, No. 12 ( 2021-12-25), p. 797-806
    Details
    In: Russian Journal of Occupational Health and Industrial Ecology, FSBI Research Institute of Occupational Health RAMS, Vol. 61, No. 12 ( 2021-12-25), p. 797-806
    Abstract: In the Russian Federation, "Mining" is a priority activity in the group "Activities in the field of industry and agriculture" for the potential risk of harm to health. The study aims to perform a hygienic analysis of violations of sanitary and epidemiological requirements for working conditions in the field of "Mining" (on the example of the Perm Region) before and after the introduction of a risk-oriented model of control and supervisory activities to manage risks to the health of the working population. Scientists performed a study according to the data of 49 inspection acts by the Rospotrebnadzor Department in the Perm Region to facilities operating in the field of "Mining," before and after the introduction of a risk-based approach (for the periods 2013-2016 and 2017-2019), using standard analysis methods. Implemented in practice in 2016, the risk-oriented approach to the control and supervision of working conditions provides for the attribution of the activities of a legal entity, an individual entrepreneur, and (or) production facilities used by them in the implementation of this activity to a particular risk category under MP 5.1.0116-17. The study used data from the Federal Register of economic entities (legal entities/sole proprietors) subject to sanitary and epidemiological supervision as of 2020; data from Rosstat and Permstat on the number of employees engaged in work with harmful and(or) dangerous working conditions, data from Rospotrebnadzor and the Department of Rospotrebnadzor in the Perm Region on occupational morbidity for 2019. The average number of violations of sanitary and epidemiological requirements to working conditions per year per economic entity in the field of Mining in the Perm Region since 2017 (since the introduction of the risk-based model of sanitary and epidemiological surveillance) has significantly decreased (p 〈 0.05) from 62 violations (in 2013-2016) to 31 (in 2017-2019), mainly due to a significant 2.5-fold decrease in the number of breaches of the requirements of Federal Law No. 52-FZ per entity - from 30 violations to 12. In 2017-2019, the average number of violations of the requirements for working conditions per year per subject significantly decreased compared to 2013-2016 (p 〈 0.05) due to a reduction in violations of the requirements for the maintenance of industrial and household premises (by 11.9 times). In the period 2017-2019, regarding 2013-2016, the contribution of violations under requirements for the maintenance of industrial and household premises, ventilation decreased by an average of 5.37 and 6.07 times, respectively, increased to overalls and PPE, production control by 3.16 and 1.67 times. The results obtained indicate that introducing a risk-based approach has led to a decrease in the number of violations of sanitary and epidemiological requirements for working conditions in the field of Mining in the Perm Region since 2017. As well as an increase in the overall structure of violations of the proportion of violations of requirements, non-compliance with which can lead to severe consequences for human health (increased the proportion of violations of requirements for overalls, PPE, working conditions with a PC, production control).
    Type of Medium: Online Resource
    ISSN: 2618-8945 , 1026-9428
    URL: Issue
    URL: Article
    DOI: 10.31089/1026-9428-2021-61-12
    DOI: 10.31089/1026-9428-2021-61-12-797-806
    Language: Unknown
    Publisher: FSBI Research Institute of Occupational Health RAMS
    Publication Date: 2021
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  • 10
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    Regulation of Organism's Antiviral Immune Response: Mathematical Model, Qualitative Analysis, Results
    Institute of Mathematical Problems of Biology of RAS (IMPB RAS) ; 2023
    In:  Mathematical Biology and Bioinformatics Vol. 18, No. Suppl. ( 2023-07-08), p. t17-t37
    Details
    In: Mathematical Biology and Bioinformatics, Institute of Mathematical Problems of Biology of RAS (IMPB RAS), Vol. 18, No. Suppl. ( 2023-07-08), p. t17-t37
    Type of Medium: Online Resource
    ISSN: 1994-6538
    URL: Article
    DOI: 10.17537/2023.18.t17
    Language: Unknown
    Publisher: Institute of Mathematical Problems of Biology of RAS (IMPB RAS)
    Publication Date: 2023
    detail.hit.zdb_id: 2781035-5
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