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  • 1
    Online Resource
    Online Resource
    Predictors of Developing Hepatocellular Carcinoma in Treated HCV-Carriers in Morocco according to University Hospital Experience
    Hindawi Limited ; 2013
    In:  ISRN Hepatology Vol. 2013 ( 2013-12-23), p. 1-3
    Details
    In: ISRN Hepatology, Hindawi Limited, Vol. 2013 ( 2013-12-23), p. 1-3
    Abstract: Introduction . Hepatitis C is the first major cause for HCC in Morocco. Antiviral treatment reduces the risk of developing HCC but few cases of HCC in HCV-treated patients were reported. We aimed to define this population’s features and to identify predictive factors of developing HCC. Patients and Methods . We included all HCV carriers who developed HCC after antiviral treatment from January 2002 to April 2010. We compare HCV-treated patients with no developed HCC to HCC population using khi-2 and Fisher Exact analysis. Results . 369 HVC-treated patients were considered, and 20 HCC were reported. The risk of HCC was not significant according to gender and genotypes (resp., P = 0.63 and P = 0.87 ). Advanced age and severe fibrosis were significant risk factors (resp., P = 0.003 and P = 0.0001 ). HCC was reported in 2.6% of sustained virological responders versus 12.5% of nonresponders ( P = 0.004 ). Conclusion . In our series, 5% of previously treated patients developed an HCC. Advanced age and severe fibrosis at HCV diagnosis are predictive factors of HCC occurrence. Sustained virological response reduces considerably the risk of HCC occurrence but screening is indicated even after SVR.
    Type of Medium: Online Resource
    ISSN: 2314-4041
    URL: Article
    DOI: 10.1155/2013/438306
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2013
    detail.hit.zdb_id: 2719566-1
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  • 2
    Online Resource
    Online Resource
    Hepatitis B genotypes/subgenotypes and MHR variants among Moroccan chronic carriers
    Elsevier BV ; 2011
    In:  Journal of Infection Vol. 63, No. 1 ( 2011-07), p. 66-75
    Details
    In: Journal of Infection, Elsevier BV, Vol. 63, No. 1 ( 2011-07), p. 66-75
    Type of Medium: Online Resource
    ISSN: 0163-4453
    URL: Article
    DOI: 10.1016/j.jinf.2011.05.007
    RVK:
    XA 54270
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2011
    detail.hit.zdb_id: 2012883-6
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  • 3
    Online Resource
    Online Resource
    CoVID-19: a Digestive Disease!
    Medical and Surgical Research Journals Group (MSRJGroup) ; 2020
    In:  Journal of Medical and Surgical Research
    Details
    In: Journal of Medical and Surgical Research, Medical and Surgical Research Journals Group (MSRJGroup)
    Abstract: CoVID-19 is a Public Health Emergency of International Concern. Since the first case has been reported in Wuhan in China, evidence of associated severe acute respiratory syndrome is well established and the disease is accepted as a primarily respiratory infection. However, current available data are supporting a gastrointestinal tropism with great implications at multiple levels in the course of this disease. The gastrointestinal tract appears in the heart of the strategy for management of infected patients from diagnosis to post-recovery isolation policies. This review highlights the digestive aspects of CoVID-19. Keywords: ACE2, CoVID-19, Digestive, Endoscopy, Fecal transmission, Liver, Prognosis
    Type of Medium: Online Resource
    ISSN: 2351-8200
    URL: Journal
    URL: Article
    DOI: 10.46327/msrjgjmsr
    DOI: 10.46327/msrjg.1.000000000000159
    Language: English
    Publisher: Medical and Surgical Research Journals Group (MSRJGroup)
    Publication Date: 2020
    detail.hit.zdb_id: 2857597-0
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  • 4
    Online Resource
    Online Resource
    Fecal calprotectin and RT-PCR from both nasopharyngeal swab and stool samples prior to treatment decision in IBD patients during CoVID-19 outbreak.
    Elsevier BV ; 2020
    In:  Digestive and Liver Disease Vol. 52, No. 11 ( 2020-11), p. 1230-
    Details
    In: Digestive and Liver Disease, Elsevier BV, Vol. 52, No. 11 ( 2020-11), p. 1230-
    Type of Medium: Online Resource
    ISSN: 1590-8658
    URL: Article
    DOI: 10.1016/j.dld.2020.05.039
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2020
    detail.hit.zdb_id: 2061359-3
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  • 5
    Online Resource
    Online Resource
    Hepatocellular carcinoma screening is indicated even after sustained virological response: -Moroccan University Hospital Experience-
    Medical and Surgical Research Journals Group (MSRJGroup) ; 2016
    In:  Journal of Medical and Surgical Research
    Details
    In: Journal of Medical and Surgical Research, Medical and Surgical Research Journals Group (MSRJGroup)
    Abstract: Introduction: Hepatitis C is the first aetiologic agent for HCC in Morocco. Antiviral treatment reduces the risk of developing HCC in patients with chronic hepatitis C but few cases of HCC have been still reported. We aimed to define population with high risk of HCC occurrence, confirm the protective role of SVR and to identify predictive factors of developing HCC after SVR. We'll try to present suggestions about screening strategies (indications and interval) after antiviral therapy according to level of HCC occurrence risk. Patients and Methods: We included all patients with chronic hepatitis C treated in our department from January 2002 to April 2010. We compare HCV-treated patients with no developed HCC to HCC population using khi-2 and Fisher Exact analysis. Results: 369 patients treated for hepatitis C were considered, and 20 HCC were reported. The risk of HCC occurrence was not significant according to gender and genotypes. Advanced age and severe fibrosis were significant risk factors. HCC was reported in 2.3% of sustained virological responders versus 12.5% of non responders. SVR is a significant protective factor. Conclusion: In our series, 5% of previously treated HCV carriers developed HCC and 2.3% of sustained virological responders developed. Achieving SVR after antiviral therapy is a protective factor. Advanced age ( 〉 50 y. o), severe fibrosis (F 〉 2) and lack of SVR at HCV diagnosis are predictive factors of HCC development in treated patients. Regular bi-annual ultrasonography screening should be indicated necessarily in patients with advanced fibrosis stage (F3- F4) even after SVR, particularly when co-morbid conditions are associated (advanced age, NASH, diabetes mellitus,...). Screening interval in sustained virological responders with reduced fibrosis stage may be limited to annual surveillance. Establishing guidelines about consensual strategy to survey sustained virological responders is now necessary especially with high rates of SVR and the extension of treatment indications in era of DAA drugs. Keywords: Hepatocellular Carcinoma (HCC), Screening, Sustained Virological Response (SVR)
    Type of Medium: Online Resource
    ISSN: 2351-8200
    URL: Journal
    URL: Article
    DOI: 10.46327/msrjgjmsr
    DOI: 10.46327/msrjg.1.000000000000064
    Language: English
    Publisher: Medical and Surgical Research Journals Group (MSRJGroup)
    Publication Date: 2016
    detail.hit.zdb_id: 2857597-0
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  • 6
    Online Resource
    Online Resource
    Long-Term Results of Percutaneous Management of Liver Hydatid Cysts: - Experience of a University Hospital in Endemic Region
    Medical and Surgical Research Journals Group (MSRJGroup) ; 2016
    In:  Journal of Medical and Surgical Research
    Details
    In: Journal of Medical and Surgical Research, Medical and Surgical Research Journals Group (MSRJGroup)
    Abstract: Background and objective: Surgery was considered for years the standard treatment for all stages of liver hydatid cysts (LHC). Percutaneous treatment has becomes a fast, reliable and more efficient method in selected cases. The purpose of this study is to evaluate the effectiveness of percutaneous treatment of LHC on the basis of our department long-term results. Patients and Methods: This study includes all patients who benefited from percutaneous treatment for LHC from December 1998 to April 2012. Puncture aspiration, injection, and re-aspiration (PAIR) were used for hydatid cysts smaller than 6 cm. Larger cysts, infected cysts and those with biliary fistula were treated by puncture associated to drainage (PA-PD). Absolute alcohol was used as sclerosing agent. Reduction of the size of the cyst more than 50%, pseudo-tumour echo pattern and disappearance of the cyst at the follow-up were retained as criteria of treatment efficacy. Results: Two hundred thirty patients (136 female and 94 male; mean age: 35 years old) with 278 LHC underwent percutaneous treatment. Mean initial cyst diameter was 76.8 mm [20-180 mm]. According to Gharbi's classification, types I and II LHC accounted for 74% and 25% respectively. Fourteen patients (6%) presented with an infected cavity and 27 patients (12%) had a biliary fistula at diagnosis (12%). PA-PD was initially performedin 23 patients. No mortality, abdominal dissemination, or tract seeding occurred. Minor complications like urticaria, cutaneous rash and fever were reported in 24 patients (10%). One case of anaphylactic shock was reported with good evolution. Mean hospitalization time was 3 days ± 1.5 for uncomplicated cases and 16.5 days± 4.2 for complicated cases. 229 out of 230 patients were cured, whereas one recurrence has been reported. Conclusion: Percutaneous treatmentis efficient and safe and offers complete cure in selected patients with the advantage of short hospitalization. Keywords: Drainage, Hydatid Cyst, Liver, Morocco, Percutaneous Puncture, Ultrasound (US)
    Type of Medium: Online Resource
    ISSN: 2351-8200
    URL: Journal
    URL: Article
    DOI: 10.46327/msrjgjmsr
    DOI: 10.46327/msrjg.1.000000000000077
    Language: English
    Publisher: Medical and Surgical Research Journals Group (MSRJGroup)
    Publication Date: 2016
    detail.hit.zdb_id: 2857597-0
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