In:
Advanced Synthesis & Catalysis, Wiley, Vol. 364, No. 4 ( 2022-02-15), p. 890-896
Abstract:
Catalytic tandem cyclization of ynamides has attracted considerable interest in organic synthesis because of its atom economy in the rapid formation of polycyclic compounds. However, examples on the construction of pentacyclic spiroindolines are quite scarce. Herein, we described a BiCl 3 ‐mediated tandem cyclization reaction of tryptamine‐ynamides, which led to the formation of appealing pentacyclic spiroindoline scaffolds in moderate to excellent yields. In addition, such a reaction can lead to the divergent synthesis of tricyclic indole derivatives with moderate yields by engineering substrate structures. The synthetic utility of this methodology has also been demonstrated by further interesting transformations. magnified image
Type of Medium:
Online Resource
ISSN:
1615-4150
,
1615-4169
DOI:
10.1002/adsc.202101232
Language:
English
Publisher:
Wiley
Publication Date:
2022
detail.hit.zdb_id:
2041384-1
detail.hit.zdb_id:
2033084-4
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