In:
PLOS Pathogens, Public Library of Science (PLoS), Vol. 17, No. 3 ( 2021-3-1), p. e1009365-
Abstract:
Parasites alter host energy homeostasis for their own development, but the mechanisms underlying this phenomenon remain largely unknown. Here, we show that Cotesia vestalis , an endoparasitic wasp of Plutella xylostella larvae, stimulates a reduction of host lipid levels. This process requires excess secretion of P . xylostella tachykinin (PxTK) peptides from enteroendocrine cells (EEs) in the midgut of the parasitized host larvae. We found that parasitization upregulates PxTK signaling to suppress lipogenesis in midgut enterocytes (ECs) in a non-cell-autonomous manner, and the reduced host lipid level benefits the development of wasp offspring and their subsequent parasitic ability. We further found that a C . vestalis bracovirus (CvBV) gene, CvBV 9–2 , is responsible for PxTK induction, which in turn reduces the systemic lipid level of the host. Taken together, these findings illustrate a novel mechanism for parasite manipulation of host energy homeostasis by a symbiotic bracovirus gene to promote the development and increase the parasitic efficiency of an agriculturally important wasp species.
Type of Medium:
Online Resource
ISSN:
1553-7374
DOI:
10.1371/journal.ppat.1009365
DOI:
10.1371/journal.ppat.1009365.g001
DOI:
10.1371/journal.ppat.1009365.g002
DOI:
10.1371/journal.ppat.1009365.g003
DOI:
10.1371/journal.ppat.1009365.g004
DOI:
10.1371/journal.ppat.1009365.g005
DOI:
10.1371/journal.ppat.1009365.g006
DOI:
10.1371/journal.ppat.1009365.g007
DOI:
10.1371/journal.ppat.1009365.g008
DOI:
10.1371/journal.ppat.1009365.s001
DOI:
10.1371/journal.ppat.1009365.s002
DOI:
10.1371/journal.ppat.1009365.s003
DOI:
10.1371/journal.ppat.1009365.s004
DOI:
10.1371/journal.ppat.1009365.s005
DOI:
10.1371/journal.ppat.1009365.s006
DOI:
10.1371/journal.ppat.1009365.s007
DOI:
10.1371/journal.ppat.1009365.s008
DOI:
10.1371/journal.ppat.1009365.s009
DOI:
10.1371/journal.ppat.1009365.s010
DOI:
10.1371/journal.ppat.1009365.s011
DOI:
10.1371/journal.ppat.1009365.s012
DOI:
10.1371/journal.ppat.1009365.s013
DOI:
10.1371/journal.ppat.1009365.s014
DOI:
10.1371/journal.ppat.1009365.s015
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2205412-1
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