In:
International Journal of Cancer, Wiley, Vol. 145, No. 5 ( 2019-09), p. 1395-1407
Abstract:
What's new? Angiogenin (ANG), a member of the ribonuclease A superfamily, was originally characterized from human colorectal adenocarcinoma cell lines and correlated with colorectal cancer (CRC) progression. However, its authentic role in CRC has not been explored. Here, the authors demonstrate that ANG promotes CRC metastasis through enhancing cell migration and invasion. Furthermore, a bunch of tiRNAs produced through ANG cleavage were enriched in CRC tumor tissues and metastatic cells and found to regulate ANG‐mediated metastasis. Altogether, the findings support the role of an ANG‐tiRNA regulatory axis in modulating CRC metastasis, potentially opening up new avenues for diagnosis and therapy.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
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