In:
European Addiction Research, S. Karger AG, Vol. 22, No. 4 ( 2016), p. 201-209
Abstract:
〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Different drug dependencies may have unique genetic vulnerabilities. Changes in serotonin availability and function have been linked to addiction. We investigated whether 2 serotonergic polymorphisms, 〈 i 〉 TPH1 A218C 〈 /i 〉 (rs1800532) and 〈 i 〉 5-HTT 〈 /i 〉 -linked promoter region 〈 i 〉 (5-HTTLPR) 〈 /i 〉 (rs25531), are differently associated with alcohol or opiate dependence. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Alcohol-dependent patients (n = 292), opiate-dependent patients (n = 309), and healthy controls (n = 301) were recruited from the Han Chinese population in Taiwan. Genotypes of 〈 i 〉 TPH1 A218C 〈 /i 〉 and 〈 i 〉 5-HTTLPR 〈 /i 〉 polymorphisms were analyzed using a polymerase chain reaction with restriction fragment length polymorphism. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 The genotype frequencies of the 〈 i 〉 TPH1 A218C 〈 /i 〉 polymorphisms were not significantly different in the 3 groups. The genotype frequencies of the 〈 i 〉 5-HTTLPR S+ 〈 /i 〉 ( 〈 i 〉 S/S 〈 /i 〉 , 〈 i 〉 S/L 〈 /i 〉 〈 sub 〉 〈 i 〉 G 〈 /i 〉 〈 /sub 〉 , 〈 i 〉 L 〈 /i 〉 〈 sub 〉 〈 i 〉 G 〈 /i 〉 〈 /sub 〉 〈 i 〉 /L 〈 /i 〉 〈 sub 〉 〈 i 〉 G 〈 /i 〉 〈 /sub 〉 ) polymorphisms were significantly higher in opiate-dependent patients ( & #x03C7; 〈 sup 〉 2 〈 /sup 〉 = 8.77, p = 0.01), but not after controlling for the covariates of age, gender, and interaction effect in logistic regression analysis. Moreover, there was a significant interaction between the 〈 i 〉 TPH1 A218C A/C 〈 /i 〉 and 〈 i 〉 5-HTTLPR S+ 〈 /i 〉 gene polymorphisms in opiate-dependent (OR 2.72, p = 0.01), but not in alcohol-dependent patients. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 Our data suggested that there may be a differential genetic vulnerability in serotonergic genes for alcohol and opiate addiction. However, replications of our findings are still needed.
Type of Medium:
Online Resource
ISSN:
1022-6877
,
1421-9891
Language:
English
Publisher:
S. Karger AG
Publication Date:
2016
detail.hit.zdb_id:
1482231-3
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